Histomorphometric Changes of Pancreatic Islets with Advancing Age – A Postmortem Study in A Bangladeshi Male Population

Shahriah, Sunjida; Nurunnabi, Abu Sadat Mohammad; Begum, GN; Kabir, Rassel

doi:10.3126/njms.v3i1.10361

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…Jumlah insulin yang dihasilkan sangat berhubungan dengan jumlah sel β. Temuan klinis, biologis dan histologis telah membentuk pandangan bahwa adanya hubungan perubahan struktur terhadap fungsi pankreas (Paras et al, 2014;Bosco et al, 2010). Adanya defisiensi sekresi insulin, yang menyebabkan meningkatnya kadar glukosa darah berhubungan dengan ukuran jaringan insular pankreatika (Walvekar, et al, 2016;Shahriah et al, 2014).…”

Section: Pendahuluanunclassified

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes

Solehah

Tarusu

Tandi

et al. 2019

JFG

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Diabetes is characterized by an increasing of blood levels and progressive changes in the structure of pancreatic islet of pancreas. Natural ingredients that contain antioxidants such as some cowpea leaves can be an alternative treatment for diabetes. This study aims to examine the effect of ethanol extract of some cowepea leaves (Vigna unguiculata (L.) Walp) on morphometry (perimeter and diameter) of pancreatic islet of diabetic rat models. The type of research is quasi-experimental with posttest group design. Samples were 30 male wistar rats, age 8 weeks, BW 250-300 grams, that induced by single dose of STZ 40 mg/kg BW. Rats were divided into 5 groups. Group A: normal control, Group B: negative control, Group C: positive control, Group D: DM rats with 100mg/Kg BW extract therapy, Group E: DM rats with 200mg/Kg BW extract therapy, Group F: DM rats with extract therapy 300mg/Kg BW. Blood sugar levels were measured on days 7, 14 and 21. Pancreatic tissue was prepared with 5μm thickness and stained with Hematoxylin Eosin. The sample was observed under 400x magnification microscope. The observation uses Image J software to measure the perimeter and diameter of the pancreatic insula. Data were analyzed by non-parametric Kruskal Wallis and post hoct Mann Whitney statistical tests. Blood glucose level was obtained on 21st day with the highest mean in group B (246.8±156.3) and lowest in group A (67.2 ±7.85), perimeter of pancreatic islet was significantly different (p=0.026), the diameter is significantly different (p =0.046). Ethanol extract of some cowpea (Vigna unguiculata (L.) Walp) leaves with dose of 300mg/kgBB helps to restore the blood and morphometry of pancreatic islet model of diabetic rats.

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Section: Pendahuluanunclassified

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes

Solehah

Tarusu

Tandi

et al. 2019

JFG

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A Study on Human Cadaveric Pancreas: Variations in Diameters of Islets Of Langerhans in Different Age Group

Baneswar¹,

Rabha²,

Śarmā

et al. 2021

PIJR

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INTRODUCTION: The islets of Langerhans may contain a few cells or many hundreds of polygonal cells arranged in short irregular cords that are abundantly invested with a network of fenestrated capillaries to produce a hormone with glucose-lowering effect. MATERIALS AND METHODS: The descriptive and cross-sectional study was done in the Department of Anatomy, Forensic Medicine& Pathology of Gauhati Medical College, Guwahati based on collection of 103 human pancreas aging from 13 to 78 years of both sexes.The collected samples were divided into group A (10-19 years),B (20-29 years),C (30-39 years),D (40-49 years),E (50-59 years),F (60-69 years) and G (≥70 years).Measurement of five slides selected from head, body and tail region were examined under 400 magnification. RESULTS AND OBSERVATION:The differences between the diameter of pancreatic islets for head part were statistically significant in A vs B,A vs D,A vs E,A vs F,A vs G,B vs D,B vs E,B vs F,B vs G, C vs E,C vs F,C vs G,F vs G in body part A vs B,A vs C,A vs F, A vs G,B vs C,B vs D,B vs E,B vs F,B vs G,C vs G,D vs G,E vs G and F vs G.and in tail part between A vs B,A vs C,A vs D,A vs E, A vs F, A vs G, B vs C, B vs D, B vs E, B vs G, C vs E, C vs F, C vs G, D vs F, D vs G, E vs F , E vs G and F vs G region. CONCLUSIONS:In the 3 region it was found that in the both extremities of life the diameter of islets of Langerhans was gradually decreased as age increases. Larger samples and advanced procedures in case of normal and abnormal population like people with diabetes disease for further studies may recommended.

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Histomorphometric Changes of Pancreatic Islets with Advancing Age – A Postmortem Study in A Bangladeshi Male Population

Abstract: Background:We proposed this study to see the difference in number and diameter of the islets of Langerhans of the pancreas with increasing age in Bangladeshi males, as male population is more prone to diabetes mellitus than female.

Cited by 2 publications

References 13 publications

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes

Ekstrak Etanol Daun Kacang Panjang (Vigna unguiculata (L.) Walp): Kajian Morfometri Insula Pankreatika Model Tikus Diabetes

A Study on Human Cadaveric Pancreas: Variations in Diameters of Islets Of Langerhans in Different Age Group

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