Histopathological alterations in the brain (optic tectum) of the fresh water teleost Channa punctatus in response to acute and subchronic exposure to the pesticide Chlorpyrifos

Mishra, Abha; Devi, Yogita

doi:10.1016/j.acthis.2013.07.001

Cited by 60 publications

(22 citation statements)

References 33 publications

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“…Earlier studies demonstrated a varied acute LC50 values of chlorpyrifos for different fish but the data for long-term LC50 of chlorpyrifos for fish is lacking. Mishra and Devi (2014) reported the 96-h LC50 of chlorpyrifos for adult spotted snakehead (Channa punctatus) as 812 µg/L, which is almost similar to our study. Oruç (2010) found the 96-h LC50 of chlorpyrifos for adult nile tilapia (Oreochromis niloticus) as 154 µg/L, which is about five times lower than we reported for Banded Gourami.…”

Section: Effects Of Chlorpyrifos On the Mortality Of Banded Gouramisupporting

confidence: 81%

Effects of insecticides on aquatic ecosystems in Bangladesh

Sumon

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Section: Effects Of Chlorpyrifos On the Mortality Of Banded Gouramisupporting

confidence: 81%

Effects of insecticides on aquatic ecosystems in Bangladesh

Sumon

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“…The behavioral changes that were recorded consisted of slower movements and swimming sideways might be attributed to the neurodegenerative changes that were reported in the optic tectum which in turn affect the functioning of motor coordination of the fish's body (Kermer et al, 2004). Mishra and Devi (2014) described similar lesions in the optic tectum following the administration of a sublethal dose of organophosphate pesticide Chlorpyrifos. Described lesions were mainly consisted of spongiosis, congestion, degeneration and necrosis of the different layers of the optic tectum.…”

Section: Resultsmentioning

confidence: 88%

Zinc nanoparticles induced brain lesions and behavioral changesin Tilapia nilotica and Tilapia. zillii

Afifi

Zinada

Ali

et al. 2016

IJAR

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In this study, the induced behavioral changes and neuropathology of prolonged exposure to high doses of Zinc nanoparticles (Zn-NPs) in two species of tilapia, T. nilotica and T. zilli. was investigated. Fish that were treated with 2000 µg Zn-NPs/L showed severe degenerative changes and vacuolation in the neuropil, particularly of the optic tectum, with congestion of the blood vessels of both the cerebral cortex and the meninx primitive. Loss of the Purkinje cell layer of the cerebellum was noticed as well. Fish showed behavioral changes that included loss of equilibrium, slower movement and swimming sideways. No significant differences (P < 0.05) were observed between T. nilotica and T. zilli in behavioral or pathological changes. The results highlighted the Zn-NPs neurotoxicity and its accompanied neuropathology and related behavioral changes in fish. More caution is needed during the usage of Zn-NPs to avoid possible deleterious impacts on human and animal health.

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“…The effects of chlorpyrifos on rainbow trout brain have been scarcely studied, despite these being extensively reported in other fish species (Xing et al 2010;Yen et al 2011;Khalil et al 2013;Mishra & Devi 2014). For example, Xing et al (2010) indicated that chlorpyrifos induced AChE inhibition in the brain of common carp.…”

Section: Discussionmentioning

confidence: 99%

“…Various nontarget organisms, such as fish, exposed to pesticides and water pollution may experience adverse biological effects including biochemical alterations (Bernet et al 1999;Burkepile et al 2000). The biochemical half-life of these toxic substances in the environment is long and may lead to physiological changes resulting in tissue damage (Roy et al 2006;Xing et al 2012;Mishra & Devi 2014). Thus, given the important role of fish in the human food chain, the adverse effects of pesticides on fish (Oruç 2010).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that chlorpyrifos causes contamination of surface and ground water and several studies have shown that chlorpyrifos is toxic to fish by inhibiting brain acetylcholinesterase (AChE) activity (Singh & Singh 2008;Xing et al 2012;Mishra & Devi 2014;Xing et al 2014). AChE (EC 3.1.1.7) is responsible for cholinesterase activity in the nervous system of vertebrates.…”

Section: Introductionmentioning

confidence: 99%

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Thein vitroandin vivoeffects of chlorpyrifos on acetylcholinesterase activity of rainbow trout brain

Topal

Şişecioğlu

Atamanalp

et al. 2015

Journal of Applied Animal Research

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Chlorpyrifos is widely used to control agricultural pests associated with fruit, nut and vegetable crops, despite its toxic effects and potential brain alterations in aquatic organisms. This study was carried out to determine the in vivo and in vitro effects of chlorpyrifos on rainbow trout brain acetylcholinesterase (AChE) enzyme activity. The fish were exposed to 2.25 µg/L (25% of 96 h LC 50 ), 4.5 µg/L (50% of 96 h LC 50 ) and 6.75 µg/L (75% of 96 h LC 50 ) of chlorpyrifos for 24, 48, 72 and 96 h. In vitro studies, inhibition constants (K i ) and half-maximal inhibitory concentration (IC 50 ) values for chlorpyrifos were determined by Lineweaver-Burk graphs and by plotting activity percentage vs.[I], respectively. Enzyme activities were determined by a colorimetric method. In fish exposed to chlorpyrifos 2.25 and 4.5 µg/L, enzyme inhibition was not observed (p > 0.05); however, chlorpyrifos exposure to 6.75 µg/L for 72 and 96 h caused a significant decrease in enzyme activity (p < 0.05). The IC 50 value of chlorpyrifos was found to be 30 µg/L. These results show that chlorpyrifos may cause direct cellular injury in the brain, and suggest that AChE may be used as a bioindicator for toxicological studies.

show abstract

Histopathological alterations in the brain (optic tectum) of the fresh water teleost Channa punctatus in response to acute and subchronic exposure to the pesticide Chlorpyrifos

Cited by 60 publications

References 33 publications

Effects of insecticides on aquatic ecosystems in Bangladesh

Effects of insecticides on aquatic ecosystems in Bangladesh

Zinc nanoparticles induced brain lesions and behavioral changesin Tilapia nilotica and Tilapia. zillii

Thein vitroandin vivoeffects of chlorpyrifos on acetylcholinesterase activity of rainbow trout brain

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