Histopathological and ultrastructural changes associated with herpesvirus infection in waterfowl

Salguero, Francisco J.; Sánchez-Cordón, P.J.; Núñez, Alejandro

doi:10.1080/03079450120118612

Cited by 23 publications

(13 citation statements)

References 15 publications

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“…Severe hyperaemia and haemorrhages and composed heterophils in the lungs were also observed. The overall pattern of antigen distribution and microscopic lesions in the organs examined were similar to those observed earlier (Islam & Khan, 1995;Shawky, 2000;Salguero et al, 2002). Although what determines the magnitude of DEV load in various tissues is not fully understood, the highlevel of DEV DNA in multiple systemic organs may directly results in the tissue lesions and accelerate the progression of disease.…”

Section: Resultssupporting

confidence: 55%

The pathogenesis of duck virus enteritis in experimentally infected ducks: a quantitative time-course study using TaqMan polymerase chain reaction

Yang

Cheng

et al. 2008

Avian Pathology

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Section: Resultssupporting

confidence: 55%

The pathogenesis of duck virus enteritis in experimentally infected ducks: a quantitative time-course study using TaqMan polymerase chain reaction

Yang

Cheng

et al. 2008

Avian Pathology

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“…Contrary to blue-winged teal (Anas discors) and Canada geese (Branta canadensis) that are susceptible to experimental infection with high mortalities (Wobeser & Docherty 1987), European teal (Anas crecca) and pintails (Anas acuta) are resistant to experimental infections with effective immune response only (Van Dorssen & Kunst 1955). An outbreak has been reported in non-Anseriformes waterfowl such as common coots (Fulica atra) and crested coots (Fulica cristata) (Salguero et al 2002).…”

Section: Host Rangementioning

confidence: 99%

“…Although the virus has not been isolated or identified, histopathological findings such as enteritis, multi-focal necrotic hepatitis with intra-nuclear inclusion bodies and ultra-structural findings such as viral particles and viral replication sites which are characteristic of herpes virus infection are useful in confirming the DVE infection (Salguero et al 2002). Outbreaks in domestic ducks occur especially in regions where there is a close association with aquatic environments co-habited by wild waterfowl (DeZeeuw 1930;Leibovitz & Hwang 1968a, 1968bRichter & Horzinek 1993 Baudet (1923) reported the first outbreak of DP in domestic ducks in the Netherlands.…”

Section: Host Rangementioning

confidence: 99%

Duck virus enteritis (duck plague) – a comprehensive update

Dhama

Kumar

Saminathan

et al. 2017

Veterinary Quarterly

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Duck virus enteritis (DVE), also called duck plague, is one of the major contagious and fatal diseases of ducks, geese and swan. It is caused by duck enteritis virus (DEV)/Anatid herpesvirus-1 of the genus Mardivirus, family Herpesviridae, and subfamily Alpha-herpesvirinae. Of note, DVE has worldwide distribution, wherein migratory waterfowl plays a crucial role in its transmission within and between continents. Furthermore, horizontal and/ or vertical transmission plays a significant role in disease spread through oral-fecal discharges. Either of sexes from varying age groups of ducks is vulnerable to DVE. The disease is characterized by sudden death, vascular damage and subsequent internal hemorrhage, lesions in lymphoid organs, digestive mucosal eruptions, severe diarrhea and degenerative lesions in parenchymatous organs. Huge economic losses are connected with acute nature of the disease, increased morbidity and mortality (5%-100%), condemnations of carcasses, decreased egg production and hatchability. Although clinical manifestations and histopathology can provide preliminary diagnosis, the confirmatory diagnosis involves virus isolation and detection using serological and molecular tests. For prophylaxis, both live-attenuated and killed vaccines are being used in broiler and breeder ducks above 2 weeks of age. Since DEV is capable of becoming latent as well as shed intermittently, recombinant subunit and DNA vaccines either alone or in combination (polyvalent) are being targeted for its benign prevention. This review describes DEV, epidemiology, transmission, the disease (DVE), pathogenesis, and advances in diagnosis, vaccination and antiviral agents/therapies along with appropriate prevention and control strategies.

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“…The disease is currently common in many countries123 In China, it was first reported by Huang et al . in 19574, and sporadic cases have been reported in many regions in recent years25.…”

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confidence: 99%

Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus

Hong

et al. 2016

Sci Rep

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Duck plague caused by duck plague virus (DPV) is an acute and contagious disease. To better understand the pathogenic mechanism of duck plague virus in ducklings, an infection experiment was performed. Our results showed that typical symptoms were observed in the infected ducklings. DPV could replicate quickly in many tissues, leading to pathological lesions, especially on the spleen. Real-time quantitative PCR demonstrated that expression of many innate immune-related genes was mostly up-regulated in the brain, and the antiviral innate immune response was established, but not sufficient to restrict viral replication. In contrast, although the expression of many major pattern recognition receptors (PRRs) increased in the spleen, the expression of most cytokines was declined. Our study indicates that DPV is a pantropic virus that can replicate rapidly in tissues, causing serious pathological lesions but the immune responses are different in the spleen and brain. To our knowledge, this is the first report to systematically explore the expression profiles of the immune genes in the DPV-infected ducks. Our data provide a foundation for further study of the pathogenicity of duck plague.

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Histopathological and ultrastructural changes associated with herpesvirus infection in waterfowl

Cited by 23 publications

References 15 publications

The pathogenesis of duck virus enteritis in experimentally infected ducks: a quantitative time-course study using TaqMan polymerase chain reaction

The pathogenesis of duck virus enteritis in experimentally infected ducks: a quantitative time-course study using TaqMan polymerase chain reaction

Duck virus enteritis (duck plague) – a comprehensive update

Pathogenicity of duck plague and innate immune responses of the Cherry Valley ducks to duck plague virus

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