Histopathological changes resulting from the effect of nano-graphene oxide on the liver in laboratory rats

Abd-Alsahib, Ehsan Faraj; Faris, Satar Abood

doi:10.53730/ijhs.v6ns3.8743

Cited by 1 publication

(6 citation statements)

References 29 publications

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“…[ 86 ] Abd‐Alsahib and Faris in (2022) stated that GO NPs with a concentration of 60 mg/kg/bw caused damages such as dilation of liver sinuses, proliferation of the nucleus of liver cells, thickening of the nucleus in some liver cells, penetration Inflammatory cells, bleeding and dissolution of hepatocytes in mice liver tissue. [ 10 ] Rhazouani et al. (2023) stated that GO NPs cause inflammation in liver cells.…”

Section: Discussionmentioning

confidence: 99%

“…[ 94,95 ] The toxicity of GO NPs has been fully confirmed in various cases, including oxidative stress and lipid peroxidation. [ 10–87 ] As a proposed mechanism to justify these observations, it can be suggested that the EAFE, due to its antioxidant properties, can neutralize free radicals caused by GO NPs and it has the ability to maintain oxidative homeostasis and combat oxidative stress in kidney, lung and testis tissues of mice. [ 96 ] Patlolla et al.…”

Section: Discussionmentioning

confidence: 99%

“…It can be said that the induction of oxidative stress increases with increasing the dose of graphene oxide nanoparticles. [10][11][12][13][14][15]16]…”

Section: Design Of Experimentsmentioning

confidence: 99%

“…[ 9 ] Abd‐Alsahib and Faris stated in (2022) that GO NPs cause histopathological damage in liver tissue such as cell rupture, thickening of nuclei in some cells, bleeding, dissolution and necrosis of cells in laboratory mice. [ 10 ] Therefore, investigating the toxicity effects of GO NPs and finding a substance to reduce these toxicity effects on living organisms is very important.…”

Section: Introductionmentioning

confidence: 99%

“…[9] Abd-Alsahib and Faris stated in (2022) that GO NPs cause histopathological dam-age in liver tissue such as cell rupture, thickening of nuclei in some cells, bleeding, dissolution and necrosis of cells in laboratory mice. [10] Therefore, investigating the toxicity effects of GO NPs and finding a substance to reduce these toxicity effects on living organisms is very important. Today, the use of herbal medicines is increasing with the aim of obtaining low-risk medicines with minimal side effects, and this is due to the fact that many herbal medicines have been proven to be low-risk in scientific societies.…”

Section: Introductionmentioning

confidence: 99%

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Investigating the protective effects ofElaeagnus angustifoliafruit extract on hematological parameters and damage of different tissues of male mice exposed to graphene oxide nanoparticles

Sayadi,

Fahoul,

Kharkan

et al. 2023

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The aim of this study is to investigate the protective effects of Elaeagnus angustifolia fruit extract (EAFE) on hematology, biochemical parameters, liver enzymes and damage of different tissues of male mice exposed to graphene oxide nanoparticles (GO NPs). In this research, 48 mice were divided into six groups. Hematology parameters including red blood cells (RBC), white blood cells (WBC), hematocrit (Ht), and hemoglobin (Hb), biochemical parameters such as cholesterol, triglyceride, glucose, protein, albumin, creatinine and bilirubin, liver enzymes including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) and histological damage of liver, kidney, lung and testis of mice were investigated. The results show that GO NPs in both concentrations (30 and 60 mg/kg/bw) decrease the number of RBC compared to the control group (p < 0.05). EAFE has no effect on RBC count while EAFE in combination with both concentrations of 30 and 60 mg/kg/bw GO NPs significantly (p < 0.05) improves the RBC count of mice. Also, the results show that EAFE improves the number of WBC, Ht, Hb, and biochemical parameters of mice exposed to different concentrations of GO NPs. A series of morphological changes were observed in the RBC of rats exposed to 60 mg/kg/bw GO NPs, including Dacrocyte, Poikilocyte and Schistocyte, which EAFE can improve the morphological changes caused in RBC. A series of histological damages such as degeneration and dilatation in the central vein in liver tissue, thickening and inflammatory cell infiltration in the renal capsule, peribronchiolar inflammatory cell infiltration and congestion in peribronchiolar blood vessels in lung tissue and decrease in the height of the germinal epithelium and a decrease in the population of spermatozoid cells in spermatogenic cells were observed in the testis of mice exposed to 60 mg/kg/bw GO NPs. The results show that EAFE can improve the damage caused by GO NPs in the liver, kidney and lung tissues, while it has no effect on the damage in the mice testis tissue. Therefore, GO NPs cause damage in the blood and different tissues of mice, and the use of EAFE can be effective in improving these damages.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…It can be said that the induction of oxidative stress increases with increasing the dose of graphene oxide nanoparticles. [10][11][12][13][14][15]16]…”

Section: Design Of Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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