Histopathological insight into a healed case of osteoradionecrosis treated with triple therapy medical management

Abstract

There is increasing interest in the management of osteoradionecrosis via pharmacological therapy as an alternative to surgery. Successful outcomes have been presented in the literature based on clinical and radiographic assessment. The current case reports on a clinically healed case of osteoradionecrosis who subsequently underwent resection for the purpose of oro‐dento‐facial rehabilitation providing a rare insight into the histopathological status of resolved case via medical management.

The use of pentoxifylline within the medical regime for the management and prevention of osteoradionecrosis in patients with cardiac‐, cerebrovascular and thromboembolic conditions

“…The combined use of PENTO aims to manage radiation‐induced fibrosis 10 . Histological analysis has now been reported of a healed ORN case managed via medical management confirming its positive effects on irradiated tissue 19 . Furthermore, using a vascular endoscope Bastos et al.…”