Histopathological patterns of gall bladder diseases with special reference to incidental cases: a hospital based study

Sharma, Ivy; Choudhury, Devajit

doi:10.18203/2320-6012.ijrms20151397

Cited by 12 publications

(20 citation statements)

References 6 publications

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“…In the present study of 161 cases, 49 cases (30.43%) were in third decade which is consistent with the study conducted by Narendra et al 7 Females were found to be predominantly affected (65.22%) compared to males (34.78%) which is similar to the studies conducted by Beena D et al, Srinivasan G et al, Sharma I et al [8][9][10] Table 3 shows comparison of age group distribution. Out of 161 cases, 160 cases (99.38%) were complaining of pain in epigastrium followed by nausea/vomiting (6.83%).…”

Section: Discussionsupporting

confidence: 91%

“…They were incidental findings. This is in concordance with studies conducted by Beena et al, Sharma et al, Goyal et al, and Arathi et al 8,10,17,18 Study have shown that incidental gall bladder carcinomas are found in about 0.5-1.1% of cholecystectomies for gall stone disease. 19 Only one case was found to be inconclusive.…”

Section: A B a Bsupporting

confidence: 91%

“…In this study, majority (93 cases, 57.76%) of the cases were diagnosed as chronic calculus cholecystitis which had presented as pain in abdomen in the right hypochondrium followed by chronic acalculus cholecystitis (36 cases, 22.36%) which is similar to study conducted by Srinivasan et al, and Sharma et al, but differs from studies conducted by Goyal et al, and Arathi et al, in which chronic acalculus cholecystitis was the histopathological diagnosis in majority of the cases. 9,10,17,18 In the present study, remaining cases are of Acute on chronic Cholecystitis (6.21%), Acute on chronic cholecystitis with cholelithiasis (4.96%), Acute on chronic cholecystitis with perforation peritonitis, Biliary Atresia, Chronic cholecystitis with choledochal cyst, Follicular Cholecystitis and Xanthogranulomatous cholecystitis (1.24% each) ( Figure 2). One case (0.62%) of Acute suppurative cholecystitis with perforation peritonitis was also found.…”

Section: A B a Bmentioning

confidence: 51%

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Histopathological spectrum of gall bladder lesions

Kulkarni¹,

Jadhav²,

Ramteke³

2020

Int J Res Med Sci

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Background: Gall bladder diseases are a very common health problem that affects millions of people throughout the world. Cholelithiasis is commonly associated with carcinoma gallbladder. Cholecystectomy is the most commonly performed surgical procedure done for gall bladder disease.Methods: A total of 161 cases of gall bladder lesions were evaluated from January 2017 to December 2018 which were sent to department of pathology. Specimens were fixed in 10% formalin. Appropriate areas were selected from the specimen and grossed, processed, sectioned, stained using haematoxylin and eosin and were observed under microscope.Results: Out of 161 cases, 105 were female (65.22%) and 56 cases were male (34.78%).Histopathologically, the most common diagnosis was Chronic calculus cholecystitis (57.76%) followed by chronic acalculus cholecystitis (22.36%). Remaining cases were of Acute on chronic cholecystitis (6.21%), Acute on chronic cholecystitis with cholelithiasis (4.96%), Acute on chronic cholecystitis with perforation peritonitis (1.24%), Acute suppurative cholecystitis with perforation peritonitis (0.62%), Biliary Atresia (1.24%), Chronic cholecystitis with choledochal cyst (1.24%), Follicular cholecystitis (1.24%), Adenocarcinoma (0.62%), Adenosquamous carcinoma (0.62%) and one case was inconclusive (0.62%).Conclusions: The incidence of chronic calculus cholecystitis was found to be 57.76% with female preponderance and mostly in third decade. Malignancy of gall bladder is a rare condition. Routine histopathological examination of all cholecystectomy specimens is strongly recommended for the detection of various variants of chronic cholecystitis and also of incidental carcinoma of gall bladder which helps in their treatment and prognosis.

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Section: Discussionsupporting

confidence: 91%

Section: A B a Bsupporting

confidence: 91%

Section: A B a Bmentioning

confidence: 51%

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Histopathological spectrum of gall bladder lesions

Kulkarni¹,

Jadhav²,

Ramteke³

2020

Int J Res Med Sci

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“…Few studies reported this ratio to be as high as four times to six times. [8][9][10] inactive lifestyle and sex hormones have been incriminated in explaining the higher incidence of cholelithiasis for women in India. 2 Maximum incidence was noted in 4 th and 5 th decades in our study and the mean age was 43 years.…”

Section: Discussionmentioning

confidence: 99%

“…This is comparable to age and gall stone findings observed in few other studies. [8][9]11 41-50 years of life (5 th decade) is reported to witness peak incidence. 10 In our study we did not get any case that was younger than 20 years of age during the study period.…”

Section: Discussionmentioning

confidence: 99%

Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

2020

IJPO

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Introduction: Gallstone disease is a major health problem and puts notable burden on individuals and health care system worldwide. This research was carried out to study the varied histopathological changes in the gallbladder mucosa as a result of cholelithiasis. Materials and Methods: The present research comprised 190 gallbladder specimens obtained from cholecystectomy procedures conducted at tertiary teaching hospital in Bangalore. The gross examination was done after fixing the specimens with 10% formalin. Haematoxylin and eosin was used to stain gallbladder sections from fundus, body and neck. Results: On gross examination, congestion was noticed on surface of gall bladder in 67 cases (35.26%), wall was thickened in more than half of cases 104 (54.74%). Nearly a quarter of specimens showed pathological changes in mucosa of gallbladder (23.15%). Histopathological examination observed evident epithelial hyperplasia in 80 cases (42.1%), antral metaplasia in 20 (10.5%), intestinal metaplasia in 12 (6.3%), dysplasia with carcinoma in one case (0.53%). Conclusion: Gallstones produce a wide range of histopathological changes in mucosa and calls for dedicated attention of pathologist routinely.

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Can gallbladder wall thickness by gross examination predicts its carcinoma before histopathological study?

Navyashree

Giriyan

2019

Trop J Pathol Microbiol

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Background: The gallbladder lesions are often underappreciated. Though gallbladder carcinomas are less in incidence, it is important to examine all gallbladders on removal so that carcinomas are not missed. In this regard, this study is about predicting the risk of carcinoma gallbladder on gross examination, so that no carcinoma cases are missed and also unnecessary histopathological examination of non-neoplastic conditions which forms the major bulk of gallbladder pathology can be avoided. Objectives: 1) To study gross and microscopic features of gallbladder in cholecystectomy specimens. 2) To study association of gross features and carcinoma of gallbladder. Methods: A 4 years study was conducted on 316 specimens of cholecystectomy in KIMS, Hubballi from June 2014 to May 2018. Gallbladder specimens were processed by standard procedures and histopathological patterns were studied. Results: The present study included patients from 7 to 87 years of age with Male: Female ratio 1:1.8 and majority were in 5 th and 7 th decade. Chronic cholecystitis (78.6%) was most common gallbladder lesion. Incidence of gallbladder carcinoma was 1.89% and majority were in 7 th decade. Statistically significant association was found between carcinoma and increased thickness of gallbladder wall.

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Histopathological patterns of gall bladder diseases with special reference to incidental cases: a hospital based study

Cited by 12 publications

References 6 publications

Histopathological spectrum of gall bladder lesions

Histopathological spectrum of gall bladder lesions

Histopathological spectrum of cholecystectomy specimens in a tertiary care hospital in Bangalore

Can gallbladder wall thickness by gross examination predicts its carcinoma before histopathological study?

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