Histopathological study of vascular changes after intra‐arterial and intravenous injection of N‐butyl‐2‐cyanoacrylate

Abstract

The histopathological changes after injection of N-butyl-2-cyanoacrylate were similar in the arteries and the veins with the exception of hyperplasia of elastic fibrils in the arterial wall and inflammation and necrosis in the venous wall at 2-3 weeks. Glue extrusion was seen in both arteries and veins.

Transcatheter Arterial Embolization of Acute Arterial Bleeding in the Upper and Lower Gastrointestinal Tract with N-Butyl-2-Cyanoacrylate

“…Wang et al (26) reported the results of an animal study in which the main manifestation of histopathology at 3 days to 2 weeks was an acute inflammatory reaction; this progressed to subacute vasculitis at 3 weeks and a chronic granulomatous foreign body reaction at 4 weeks. No inflammatory reaction was noted in the specimen of patient L-2; this may have been due to healing of inflammation with a long interval between NBCA embolization and surgery.…”

Pancreatitis after transcatheter embolization of a splenic aneurysm

“…Moreover, the strong reactivity of the ionization-produced polymerization of NBCA causes major vascular cytotoxicity by damaging the vascular intima and triggering infl ammatory and immunological foreign body responses. 7 These characteristics of NBCA can cause massive pancreatitis.…”

Recurrent Walled-Off Necrosis Following Embolization with N-Butyl-2-Cyanoacrylate in a Patient with Upper Gastrointestinal Tract Bleeding

“…However, compared to embolization with coils, TAE using NBCA carries a potential risk of sta- sis for more peripheral arteries. Moreover, the strong reactivity of ionization-produced polymerization of NBCA causes major vascular cytotoxicity by damaging the vascular intima and triggering inflammatory and immunological foreign body responses [17]. These characteristics of NBCA may result in pancreatitis.…”