Historical Criteria for Structural Classes of Proteins in Percentages: After 20 Years

Abstract

In SCOP database, a protein is mainly classified into of the following five structural classes: all α, α/β. Experts at SCOP have an intuition to decide about the structural class of a new protein. However no explicit formulation of this intuition revealed to the time. structural class of a protein is hypnotized that it is somehowcorrelated with its amino acid composition. Various efforts have been made in finding coherent criteria that will help one to find out the structural class of a given protein. This article addresses the start and progress in this field. There are two theoretical approaches to predict the structure of a protein. One is the free-energy minimization