Historical Review

Volk, Bruno W.

doi:10.1007/978-1-4615-8726-2_1

Cited by 3 publications

(1 citation statement)

References 172 publications

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“…The Discovery of Insulin (8)(9)(10) Cawley is credited as the first physician to associate diabetes with pancreas, while von Mering and Minkowski established that total pancreatectomy in dogs caused diabetes. (2) Trommer described qualitative test for sugar in the urine in 1841, and Fehling discovered a quantitative test in 1850.…”

Section: Experimental Period (1850-1921)mentioning

confidence: 99%

Diabetes Mellitus From Mystery To Manageable Disease & Insulin Transition From Antiquity To Modern Era

JMMDC¹

2022

JMMDC

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Men and MilestonesA better understanding of the contemporary sphere of diabetes mellitus may be aided by a historical summary. The study of both the remote and recent literature requires substantial knowledge of medicine and the basic sciences underlying the pathology of the disease. The historical perspective of diabetes mellitus guides us in a better understanding the disease and the care of patients. The evolution in the understanding of diabetes is divided into four eras as follows: (1-4) Ancient Period Diagnostic Period Period of Empiric Treatment Experimental Period

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Section: Experimental Period (1850-1921)mentioning

confidence: 99%

Diabetes Mellitus From Mystery To Manageable Disease & Insulin Transition From Antiquity To Modern Era

JMMDC¹

2022

JMMDC

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Lipid Storage Disease : Part Ii

Takahashi

Naito

1985

Acta Pathologica Japonica

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The ultrastructural pathology of the stored materials in lipid storage cells, particularly of macrophagic nature, in various disorders of sphingolipidosis was investigated. Cell morphology of the lipid storage cells was largely divided into two groups; one had peculiar cell morphology, such as Gaucher cells or globoid cells, and the other showed the appearance of foam cells. These cytological characteristics of the lipid storage cells were closely related to the ultrastructural configuration of lipid storage inclusions. By transmission electron microscopy, the fundamental structures of the stored materials were classified into two types; tubular and lamellar. The tubular structures were formed by accumulation of ceramide or monohexosyl ceramide, whereas the lamellar structures were formed by accumulation of larger sphingolipids than monohexosyl ceramide. These tubular structures were proven to consist of multilayers of lamellae, which are considered fundamentally similar to the lamellar structures. Almost all the lipid storage inclusions are considered to be of lysosomal origin, because of their encirclement by a single unit membrane and localization of acid phosphatase activity, and participation of heterophagic or autophagic mechanisms as for the development of the inclusions may be noted. Besides, the occurrence of secondary lipid storage was pointed out in some disorders of sphingolipidosis. ACTA PATHOL. JPN. 35 : 385–408, 1985.

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Increased Acetylcholine Synthesis and Release in Brains of Cats with G_M1 Gangliosidosis

Jope¹,

Baker

Connor

1986

Journal of Neurochemistry

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Cholinergic processes were measured in motor cortex, hippocampus, and striatum of cats in the terminal stages of GM1 gangliosidosis and compared to those of control cats. The greatest difference observed was elevation in the rate of K+-stimulated release of acetylcholine (ACh) from brain slices prepared from affected cats. The K+-stimulated release of endogenous ACh was increased by 31-43% and of newly synthesized ACh by 19-80% in brain slices from different brain regions. All regions that were examined were affected but the greatest effects occurred in cortex. The rate of synthesis of ACh was elevated in cortical and hippocampal slices. Choline acetyltransferase activity in brain regions of cats with GM1 gangliosidosis was not significantly different from that in controls, whereas high-affinity choline transport in cortical synaptosomes was elevated. Muscarinic receptor binding sites were reduced in the cortex, hippocampus, and striatum of GM1 mutant cats, whereas the apparent affinity was not altered. These results indicate that there are major alterations of cholinergic function in the brains of cats with GM1 gangliosidosis.

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Historical Review

Cited by 3 publications

References 172 publications

Diabetes Mellitus From Mystery To Manageable Disease & Insulin Transition From Antiquity To Modern Era

Diabetes Mellitus From Mystery To Manageable Disease & Insulin Transition From Antiquity To Modern Era

Lipid Storage Disease : Part Ii

Increased Acetylcholine Synthesis and Release in Brains of Cats with G_M1 Gangliosidosis

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Historical Review

Cited by 3 publications

References 172 publications

Diabetes Mellitus From Mystery To Manageable Disease & Insulin Transition From Antiquity To Modern Era

Diabetes Mellitus From Mystery To Manageable Disease & Insulin Transition From Antiquity To Modern Era

Lipid Storage Disease : Part Ii

Increased Acetylcholine Synthesis and Release in Brains of Cats with GM1 Gangliosidosis

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Product

Resources

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Increased Acetylcholine Synthesis and Release in Brains of Cats with G_M1 Gangliosidosis