2007
DOI: 10.1016/j.bmcl.2007.09.076
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Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases

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Cited by 80 publications
(67 citation statements)
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“…In order to obtain potential compounds with specific inhibitory effect against Aurora-A kinase, we used the Aurora-A kinase activity assay kit developed by Cell Signaling Technology. Compound 1a was synthesized 21 and used as positive controls. The anti-proliferative cytotoxic activity was also evaluated by using HCT116 tumor cell line.…”
Section: Resultsmentioning
confidence: 99%
“…In order to obtain potential compounds with specific inhibitory effect against Aurora-A kinase, we used the Aurora-A kinase activity assay kit developed by Cell Signaling Technology. Compound 1a was synthesized 21 and used as positive controls. The anti-proliferative cytotoxic activity was also evaluated by using HCT116 tumor cell line.…”
Section: Resultsmentioning
confidence: 99%
“…1) [7,17e19]. Recently, a series of imidazo [4,5-b]pyridine derivatives as orally bioavailable Aurora A inhibitors with excellent potencies were reported [15,16]. In order to investigate the key structural features required to design potential Aurora A inhibitor drug candidates from imidazo [4,5-b]pyridine derivatives, we have performed 3D-QSAR and docking analyses on a set of sixty derivatives.…”
Section: Introductionmentioning
confidence: 99%
“…Substituted imidazo [4,5-b]pyridines have also been explored for their potential as anticancer [13,14], inotropic, [15,16], and selective antihistamine (H1) agents [17]. Imidazo [4,5-b]pyridine derivatives are also reported as Aurora kinases [18] and cyclic phosphodiesterase inhibitors [19]. Recently, the synthesis of imidazo [4,5-b]pyridine derivatives has been one of the interests in the field of organic synthesis.…”
Section: Introductionmentioning
confidence: 99%