HIV-1 Proteomics 2016
DOI: 10.1007/978-1-4939-6542-7_2
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HIV-1 Biology at the Protein Level

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“…A relatively small virus (~100–120 nm), the spherical HIV-1 particles contain two copies of non-covalently linked positive-sense single-stranded RNA genome of ~10 kilobases (Kb) size [ 51 , 52 ]. This viral genomic RNA (vRNA), harboring several functional secondary structures, contains nine genes encoding 15 canonical proteins [ 53 , 54 ]. As an obligate intracellular parasite, HIV-1 relies on host cell machinery and proteins for its productive replication in infected cells.…”
Section: Hiv-1 Replicationmentioning
confidence: 99%
“…A relatively small virus (~100–120 nm), the spherical HIV-1 particles contain two copies of non-covalently linked positive-sense single-stranded RNA genome of ~10 kilobases (Kb) size [ 51 , 52 ]. This viral genomic RNA (vRNA), harboring several functional secondary structures, contains nine genes encoding 15 canonical proteins [ 53 , 54 ]. As an obligate intracellular parasite, HIV-1 relies on host cell machinery and proteins for its productive replication in infected cells.…”
Section: Hiv-1 Replicationmentioning
confidence: 99%