“…Thus, overall, our data are consistent with some of the earlier reports showing that incoming HIV-1 particles are not a strong inducer for a type I IFN response that depends on cGAS sensing of HIV-1 DNA ( 11 , 31 , 42 , 47 , 60 , 84 – 86 ). It should be noted, however, that the early phase is not the only period during which HIV-1 can be sensed, as multiple lines of evidence point to innate immune responses that are elicited by late events of the viral replication cycle ( 13 , 15 , 32 , 33 , 35 , 51 , 87 , 88 ).…”