HIV/AIDS: Current Updates on the Disease, Treatment and Prevention

Gupta, Praveen; Saxena, Apoorva

doi:10.1007/s40011-021-01237-y

Cited by 14 publications

(5 citation statements)

References 18 publications

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“… 1 ART-free human immunodeficiency virus (HIV) remission, while desirable, has only been achieved in a few individuals, including five bone-marrow transplant recipients and at least two natural controllers with extremely low HIV reservoir. 2 Rare people with HIV (PWH), termed “elite controllers,” can naturally control HIV replication below the limit of routine clinical assays in the absence of ART. 3 , 4 HIV-specific CD8 + T cells with high functionality have been considered key to achieving HIV control in elite controllers.…”

Section: Introductionmentioning

confidence: 99%

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

Takata,

Mitchell,

Pacheco

et al. 2023

Cell Host & Microbe

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Section: Introductionmentioning

confidence: 99%

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

Takata,

Mitchell,

Pacheco

et al. 2023

Cell Host & Microbe

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“…HIV is a retrovirus that causes HIV infection, which in the later stages leads to acquired immune deficiency syndrome (AIDS) [ 2 ]. According to the 2022 Global World Health Organization (WHO) HIV report, an estimated 39 million people are living with HIV and around 630,000 people died due to HIV in 2022 [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

HIV Versus the Human Body: A Case Report of an Immunity-Compromised Patient

Karnan,

Jadhav,

Ghewade

et al. 2024

Cureus

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The immune system is the body’s defense system against infection, pathogenic organisms, or foreign bodies. Human immunodeficiency virus (HIV) infection significantly reduces the number of cells involved in the immune system making the infected person prone to a greater number of infections like tuberculosis (TB). HIV infection reduces the CD4 T helper cell count and further replicates within the body. HIV-TB is a major health concern as there is more chance of progression to acquired immunodeficiency syndrome (AIDS) and the emergence of drug-resistant TB. In this case report, we see how the HIV-TB infection affects the body, significantly affecting the morbidity and mortality of the patient.

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“…Because of Timothy Ray Brown, otherwise known as the “Berlin Patient,” who became the first person to be cured of HIV after receiving a stem cell transplant from a donor who had a rare genetic mutation known as CCR5 delta 32, which makes cells resistant to HIV infection, stem cell transplantation (SCT) has gained attention in HIV management. [49] Stem cell transplantation is not widely accepted for treating HIV due to its high risk, complexity, and availability of compatible donors. It is quite uncommon to find a compatible donor that carries the CCR5 delta 32 mutation, like Timothy Ray Brown did.…”

Section: Stem Cell Donation For Hiv Treatmentmentioning

confidence: 99%

Toward a cure – Advancing HIV/AIDs treatment modalities beyond antiretroviral therapy: A Review

Alum,

Uti,

Ugwu

et al. 2024

Medicine

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Antiretroviral therapy, also known as antiretroviral therapy (ART), has been at the forefront of the ongoing battle against human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDs). ART is effective, but it has drawbacks such as side effects, medication resistance, and difficulty getting access to treatment, which highlights the urgent need for novel treatment approaches. This review explores the complex field of HIV/AIDS treatment, covering both established alternative treatment modalities and orthodox antiretroviral therapy. Numerous reliable databases were reviewed, including PubMed, Web of Science, Scopus, and Google Scholar. The results of a thorough literature search revealed numerous therapeutic options, including stem cell transplantation, immunotherapy, gene therapy, latency reversal agents, and pharmaceutical vaccinations. While gene therapy has promise for altering cellular resistance to infection and targeting HIV-positive cells, immunotherapy treatments seek to strengthen the immune system’s ability to combat HIV. Latency reversal agents offer a promising method of breaking the viral latency and making infected cells vulnerable to immune system destruction or antiretroviral drugs. Furthermore, there is potential for improving immune responses against HIV using medical vaccinations. This review stresses the vital significance of ongoing research and innovation in the hunt for a successful HIV/AIDS treatment through a thorough examination of recent developments and lingering challenges. The assessment notes that even though there has been tremendous progress in treating the illness, there is still more work to be done in addressing current barriers and investigating various treatment options in order to achieve the ultimate objective of putting an end to the HIV/AIDS pandemic.

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HIV/AIDS: Current Updates on the Disease, Treatment and Prevention

Cited by 14 publications

References 18 publications

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

HIV Versus the Human Body: A Case Report of an Immunity-Compromised Patient

Toward a cure – Advancing HIV/AIDs treatment modalities beyond antiretroviral therapy: A Review

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