HIV/AIDS Occurrence in the Main University Teaching Hospital in Cameroon

Kengne, André Pascal; Kaze, François Folefack; Dzudie, Anastase; Awah, Paschal Kum; Ngu, Kattlen Blackett

doi:10.1177/1545109706297550

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…These factors suggest that patients who died during hospitalization were more likely to present with poor performance status and more advanced and severe disease, leading to death early in their hospital stay. Even though CD4 counts ≤ 200cells/mm 3 were predictive of death in our cohort, some studies have reported contrary findings [23,24].…”

Section: Discussioncontrasting

confidence: 43%

“…The mean age for males was 39 ± 9 years and 33 ± 8 years for females (p, 0.001). The median CD4 count at baseline was 91 cells/mm³ with a range of 2-782 cells/mm 3 . Viral load values ranged from 200 to 2,361,858 copies/ml for the entire cohort, and 124 (35%) of the patients had a baseline viral load above 100,000 copies/ml.…”

Section: Resultsmentioning

confidence: 99%

“…The high mortality is probably reflective of the advanced nature of the disease at presentation. For example, the majority (81.5%) of the patients had CD4 counts ≤ 200 cells/mm 3 and most (92%) of the deaths were inpatients with CD4 counts below this level. In addition, stigma, delay in seeking health care, lack of HIV counseling and testing services, as well as delays in referral and ART initiation are all potential reasons for late presentation.…”

Section: Discussionmentioning

confidence: 99%

“…The HAART regimen consisted of two nucleoside reverse transcriptase inhibitors (NRTIs) and one non-nucleoside reverse transcriptase inhibitor (NNRTI) in line with national guidelines. We also extracted the patients' baseline CD4 count (cells/mm 3 ) and viral load (copies/ml) results. The majority of diagnoses reported in the charts were defined by the patient's clinician based upon clinical findings and accompanying investigations whenever possible.…”

Section: Methodsmentioning

confidence: 99%

“…Since the first case of acquired immune deficiency syndrome (AIDS) was publicized in 1986, the burden of the pandemic has grown rapidly, with current numbers of people living with the virus estimated at 3.5 to 5 million [1,2]. In resource-poor settings, between 20% and 52% of hospital beds in medical wards are occupied by HIVinfected patients at any given time, with opportunistic infections (OIs) accounting for the majority of these admissions [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians

Agaba

Digin

Makai

et al. 2011

J Infect Dev Ctries

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Introduction: Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a chief cause of death in sub-Saharan Africa. In this study, the clinical characteristics and predictors of mortality among hospitalized HIV infected adult Nigerians are reported. Methodology: The records of 354 patients were reviewed for demographic and clinical characteristics. Predictors of mortality using logistic regression in a retrospective study were also reviewed. Results: A total of 109 (30.8%) males and 245 (69.2%) females participated in the study. The mean age of all participants was 35 ± 8 years. Median baseline CD4 cell counts and viral load were 91 cells/mm³ and 63,438 copies/ml respectively. There was a total of 123 (34.8%) deaths while 231 (65.2%) patients were discharged home. Tuberculosis (TB) was the most common diagnosis on admission as well as the leading cause of death. Among all subjects, only male gender (adjusted odds ratio [AOR]

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Section: Discussioncontrasting

confidence: 43%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians

Agaba

Digin

Makai

et al. 2011

J Infect Dev Ctries

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Determinants of fructosamine levels in a multi-ethnic Sub-Saharan African population

Nouya

Nansseu

Moor

et al. 2015

Diabetes Research and Clinical Practice

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Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis

Reddy

Shaw

Crump

2010

The Lancet Infectious Diseases

584

583

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Data on the prevalence and causes of community-acquired bloodstream infections in Africa are scarce. We searched three databases for studies that prospectively studied patients admitted to hospital with at least a blood culture, and found 22 eligible studies describing 58 296 patients, of whom 2051 (13.5%) of 15 166 adults and 3527 (8.2%) of 43 130 children had bloodstream infections. 1643 (29.1%) non-malaria bloodstream infections were due to Salmonella enterica (58.4% of these non-typhoidal Salmonella), the most prevalent isolate overall and in adults, and 1031 (18.3% overall) were due to Streptococcus pneumoniae, the most common isolate in children. Other common isolates included Staphylococcus aureus (531 infections; 9.5%) and Escherichia coli (412; 7.3%). Mycobacterium tuberculosis complex accounted for 166 (30.7%) of 539 isolates in seven studies that used mycobacterial culture techniques. HIV infection was associated with any bloodstream infection, particularly with S enterica and M tuberculosis complex bacteraemia. Where recorded, patients with bloodstream infections had an in-hospital case fatality of 18.1%. Our results show that bloodstream infections are common and associated with high mortality. Improved clinical microbiology services and reassessment of empirical treatment guidelines that account for the epidemiology of bloodstream infections might contribute to better outcomes.

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HIV/AIDS Occurrence in the Main University Teaching Hospital in Cameroon

Cited by 7 publications

References 8 publications

Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians

Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians

Determinants of fructosamine levels in a multi-ethnic Sub-Saharan African population

Community-acquired bloodstream infections in Africa: a systematic review and meta-analysis

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