HIV and Aging

Erlandson, Kristine M.; Karris, Maile Y.

doi:10.1016/j.idc.2019.04.005

Cited by 79 publications

(32 citation statements)

References 102 publications

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“…Thus, people living with HIV continue to struggle with intimacy and physical pleasure because of several factors strictly linked to the HIV infection. Usually, sexual dysfunction and peculiar aspects of sexuality related to HIV remain in the background in the daily clinical practice with respect to the management of HIV infection itself and of major HIV-related comorbidities [ 6 , 9 ]. Overall, leaving sexual problems overlooked and undermanaged is known to further compromise the quality of life of these patients, which is already impaired by HIV distress, associated morbidities, and stigma [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

HIV and Sexual Dysfunction in Men

Vincentis

Tartaro

Rochira

et al. 2021

JCM

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Sexual issues tend to go unaddressed in human immunodeficiency virus (HIV) management, although overt sexual dysfunctions are more prevalent in people living with HIV than uninfected people. Erectile dysfunction is the most frequent sexual problem, with a prevalence of 30–50% even in men <40 years of age, but other issues such as loss of libido and ejaculatory disorders should not be overlooked. Peculiar factors related to HIV infection (e.g., fear of virus transmission, changes in body image, HIV-related comorbidities, HIV distress and stigma), alongside classical factors non-related to HIV, should be considered when approaching sexual problems in HIV patients. For this reason, the diagnostic and therapeutic workout of sexual dysfunction in the context of HIV requires a multidisciplinary approach, involving specialists in both infectious diseases and sexual medicine. This narrative review presents an overview of current knowledge on sexual dysfunction in HIV men, deepening the factors driving and taking part in these issues, providing advice for the clinical approach, and underlining the importance of caring for sexual health to improve the quality of life of HIV patients.

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Section: Introductionmentioning

confidence: 99%

HIV and Sexual Dysfunction in Men

Vincentis

Tartaro

Rochira

et al. 2021

JCM

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“…From the above results, we can find that some research results of ILWH are similar to those of general HIV-infected people, including aging [4][5][6][7], premature aging [8][9][10][11], the number of patients suffering from NAD is gradually increasing [7,[14][15][16][17][18], and the number of patients with multiple NAD is increasing year by year [7].…”

Section: Discussionmentioning

confidence: 81%

“…However, as some HIV-infected people do not know they have been infected with HIV (about 32.1% of HIV-infected people in China do not know their infection status), are lack of good compliance, have poor immune reconstitution, or have received organ transplants, their immunity is generally low and are prone to opportunistic infections or AIDS-related malignancies, and they need to be hospitalized for treatment and care. [1][2][3] At the same time, with the increase of the survival rate in people living with HIV (PLWH) , PLWH are facing with some new problems such as ,premature aging [4][5][6][7], increasing in biological age [8][9][10][11], frailty [12,13], multiple comorbidities [14][15][16][17][18]. Because of the serious condition, some patients also need to be hospitalized for treatment and care .…”

mentioning

confidence: 99%

Future Challenges for Changes in the Disease Burden of Inpatients Living With HIV in China: a Predictive Study

Shuai

Nie

Huang

et al. 2021

Preprint

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Objective: In China, the widespread use of Combination Antiretroviral Therapy(cART) has significantly improved the prognosis and quality of life in people living with HIV(PLWH). However, some PLWH still got worse and were hospitalized for some reasons, including AIDS-Defining Diseases(AD, such as opportunistic infections and AIDS-related Malignancies), Non-AIDS-Defining Diseases (NAD, such as non-AIDS-defining Malignancies and metabolic syndrome). At present, the age and disease of inpatients living with HIV(ILWH) are undergoing some significant changes. For example, the average age of ILWH is gradually increasing, the proportions of ILWH with NAD in all age groups are increasing, and the proportion of ILWH suffering from multiple types of NAD is increasing, which will have a greater impact to both ILWH and infectious disease hospitals. We aim to predict the changes in ILWH in the next 10 years, analyze the impact of such changes on ILWH and infectious disease hospitals in China, and propose corresponding countermeasures. Methods: We have established a prediction model based on Artificial Neural Network and Time series, using 12618 data of ILWH admitted to Chongqing Public Health Medical Center during 2010-2020, to predict the age of ILWH, the proportion of AD and NAD, the proportion of multiple types of NAD, and the proportion of NAD occurrences among various age groups from 2021 to 2030.Results: Our model shows that the average age of ILWH has risen from 43.8 years in 2010 to 57.6 years in 2030, and the increase in the age of women is greater than that of men. The number of ILWH in different age groups has changed significantly. Among them, the proportion of ILWH under 50 years old has gradually decreased, and the proportion of ILWH over 50 years old has gradually raised. By 2030, the proportion of inpatients over 50 years old will be close to 80%. The proportion of fatal opportunistic infections among ILWH has decreased year by year, and the most common diseases are tuberculosis-related diseases. The proportions of ILWH with only AD or NAD have gradually decreased, and the proportion of ILWH with both AD and NAD has increased year by year. It is estimated that the proportion of all ILWH with both AD and NAD will exceed 80% by 2030. Among all kinds of diseases in NAD, metabolic syndrome will have the highest rate of increase. By 2030, it will account for 16% in all ILWH. The proportion of hepatobiliary and pancreatic system diseases and blood system diseases in NAD will gradually decrease, while the proportion of metabolic syndrome, kidney disease, gastrointestinal disease, non-AIDS defining malignancies(NADM), bone disease and neurological diseases in NAD will gradually increase. The proportion of ILWH with NAD in all age groups will increase significantly after 10 years. Among them, the proportion of ILWH with NAD in 50-60 years old will be more than 80%, and among the ILWH under 30 years old, the proportion of ILWH suffering from NAD will increase to 69.6%. The proportion of ILWH without NAD or only 1 NAD will decrease, while the proportion of ILWH with 3 or more NAD will rise sharply. The proportion of ILWH with 1 type of NAD will drop to 12.6%, while the proportion of ILWH with 2 types of NAD, and the proportion of ILWH with 3 or more types of NAD will increase greatly. Conclusions: Significant changes have took place in the disease burden of ILWH in China, including the aging, the increase in the proportion of ILWH with NAD, and the increase in the proportion of ILWH with multiple types of NAD. These changes mean that in the next 10 years, the diagnosis, treatment and care of ILWH, as well as the development and construction of infectious disease hospitals will all face new challenges. This finding is based on a large number of long-term ILWH data in Chongqing, China, so we can consider that our research strategy can be promoted in China to improve the cure rate and quality of life in ILWH.

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“…Knowledge gaps and insurance coverage may be contributing barriers. Given estimates that predict that 70% of PWH will be 50 years and older in 2030, it is critical to prioritize health screenings that prevent negative health outcomes such as falls and fractures to preserve independent function and enhance well-being [ 27 ].…”

Section: Discussionmentioning

confidence: 99%