HIV post-exposure prophylaxis after sexual assault: the experience of a sexual assault service in London

Abstract

Compared with other published studies the completion rate of HIV-PEP in our study was high. The uptake and adverse events of HAART in this scenario were similar to previously published studies. A multidisciplinary approach to the management of this patient group will improve adherence to PEP.

HIV Postexposure Prophylaxis in Sexual Assault: Current Practice and Patient Adherence to Treatment Recommendations in a Large Urban Teaching Hospital

“…4 Our data confirm findings of previous studies reporting a low likelihood of follow-up and completion of nPEP treatment in victims of SA, with followup rates ranging from 38% to 53%, and completion rates ranging from 11% to 63%. [18][19][20]24 In fact, the completion rate of health care workers who begin nPEP (a highly motivated and knowledgeable group of patients) is in the vicinity of 30%, although they are more likely to be given a three-drug regimen that carries with it a higher likelihood of adverse reactions. 25 Although our overall completion rate was 21%, the completion rate of those patients started on nPEP from the HIV clinic was 100%, whereas only 18% of those patients who were started from the ED completed the 30-day regimen.…”

Use of HIV PEPSE and Hepatitis B vaccine following the introduction of a SARC

“…5 One hundred and fifty patients attended the service during the twelve months of the study. The patients were assessed for HIV PEP and ten were considered eligible for treatment.…”

Nonoccupational postexposure prophylaxis following sexual assault in industrialized low-HIV-prevalence countries: A review

“…Acceptance by 20-60% of patients offered nPEP was found in three additional single-site studies (Diniz, Almeida, Ribeiro, & Macedo, 2007;Reeves, Jawad, & Welch, 2004;Wiebe, Comay, McGregor, & Ducceschi, 2000). And acceptance greater than 80% was found in the remaining four studies; two conducted at single sites (Garcia et al, 2005;Limb, Kawsar, & Forster, 2002), one inclusive of city-wide data (Sonder et al, 2007), and one regional (Carrieri, Bendiane, Moatti, & Rey, 2006).…”

“…Four studies reported the frequency of baseline HIV testing (Bechtel, Ryan, & Gallagher, 2008;Campbell et al, 2006;Merchant, Phillips, Delong, Mayer, & (2007) 172 - Garcia et al (2005) 347 278 (80%) Kerr et al (2003) 676 - Limb et al (2002) 150 10 (6%) Reeves et al (2004) 92 - Rey et al (2008) 98 -Sonder et al (2007) 29 - Templeton et al (2005) 146 117 (80%) Wiebe et al (2000) 258 -Studies with US populations conducted pre-CDC guidelines Linden et al (2005) 181 167 (92%) Merchant et al (2008) 780 610 (78%) Merchant et al (2003) 461 286 (62%) Moe and Grau (2001) 58 48 (82%) Myles et al (2000) 376 354 (94%) Pesola et al (1999) 27 - Straight and Heaton (2007) 179,149 -Note: *The percentage reflects the number of patients eligible out of the total sample size. Becker, 2008;Straight & Heaton, 2007).…”