HIV Pre-Exposure Prophylaxis (PrEP) in a Brazilian Clinical Setting: Adherence, Adverse Events, Sexual Behavior, and Sexually Transmitted Infections

Barbosa, Ana Karina Pinto; Monteiro, Polyana; Montenegro, Demetrius; Batista, Joana; Montarroyos, Ulísses Ramos

doi:10.1007/s10508-021-02112-7

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…In a study of PrEP-eligible individuals in San Diego, California, adults interested in starting PrEP had a higher prevalence of recreational drug use, particularly cocaine, poppers, and ecstasy, compared with those who were not interested in start PrEP [ 5 ]. In addition, a Brazilian study of PrEP users showed that 44.3% of its cohort had reported substance use within the 12 months that preceded the study, a much higher frequency than the 3.2% reported by the general population in Brazil [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Substance Use and Risky Sexual Behavior in the PrEP Outpatient Clinic at the University Hospital of Brasília

et al. 2023

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(1) Background: To evaluate the epidemiological profile of people who use drugs at the PrEP outpatient clinic of the University Hospital of Brasília; (2) Methods: Cross-sectional study with a review of data from medical records referring to the first medical consultation. The prevalence ratio was calculated using a Poisson regression model with robust variance; (3) Results: A total of 53% of subjects reported drug use in the last 3 months. The unadjusted prevalence ratio of drug use in trans women was PR: 9.0 (95%CI: 1.4–57.5). people who use drugs have a 1.9 times higher prevalence of STI diagnosis, and a 2.4 times higher prevalence of partners compared to non-users; (4) Conclusions: Substance use was associated with a higher STI prevalence ratio and number of sexual partners.

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Section: Introductionmentioning

confidence: 99%

Substance Use and Risky Sexual Behavior in the PrEP Outpatient Clinic at the University Hospital of Brasília

et al. 2023

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“…This epidemiological scenario suggests that even though Brazil has a legal basis that allows people to access health services without parental consent from the age of 12 (Brasil, 1990 ), young people have lower access to HIV services in the country. Indeed, the literature shows that this is the case in Brazil and other countries: for instance, people aged 18 to 24 are minority among PrEP users in Brazil (Barbosa et al, 2022 ), and those between 13 and 24 are the least likely to know their HIV status in the US (Centers for Disease Control and Prevention (CDC), 2022 ; Koenig et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

"I Can’t Take This Shitty Quarantine Anymore": Sexual Behavior and PrEP Use Among Young Men Who Have Sex with Men and Transgender Women in Brazil During the COVID-19 Pandemic

et al. 2022

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This study analyzes how the COVID-19 pandemic affected sexual behavior and use of HIV prevention methods among young transgender women (YTGW) and young gay, bisexual and other men who have sex with men (YGBMSM) participating in an HIV pre-exposure prophylaxis (PrEP) demonstration study in Brazil. Online interviews with 39 participants aged 15–22 years old were conducted between September and November 2020 and analyzed based on social constructionism and human rights-based approaches to health. The pandemic disrupted interviewees’ routines, negatively affecting their life conditions. Among those who did not have a steady partner, social distance measures led to temporary interruption of sexual encounters and increased sexting and solo sex. Conversely, for those who had a steady relationship such measures contributed to increasing sexual practices and intimacy. Participants who had sexual encounters during the pandemic reported having continued to use PrEP. However, home confinement with family, lack of privacy, loss of daily routines and changes in housing impaired PrEP adherence and attendance at follow-up consultations. These results highlight the importance of maintaining HIV-service delivery for these groups during a public health crisis, as well as to address the structural drivers of the epidemic with comprehensive HIV prevention policies and by ensuring access of YGBMSM and YTGW to social protection policies.

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Fractional order modeling for injectable and oral HIV pre-exposure prophylaxis

Moya

Rodrigues

2023

MMC

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<abstract><p>The search for therapies and prevention methods for HIV infection is essential for controlling the virus in a population. In this paper, we introduce a fractional order mathematical model to study the impact of the oral to the injectable Pre-Exposured Prophylaxis modality, which is completely new in terms of public health. For that, we consider current antiretroviral therapies, undiagnosed cases, and the impact of PrEP on the case diagnosis. To investigate the model, besides the use of fractional order derivatives, we also consider illustrative cases by means of demographic data from Brazil and parameter values from the literature. We compare the influence on incidence, prevalence, diagnosis, and mortality of oral PrEP with the injectable PrEP, which is the new current trend on the subject. As a result, an increasing in incidence, prevalence and also mortality are revealed by augmented fractional order of derivatives for both PrEP modalities, but PrEP reached better results in its oral modality. Despite the need for further studies, this contribution is intended as a first preliminary step to contribute to decision-making by health authorities.</p></abstract>

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HIV Pre-Exposure Prophylaxis (PrEP) in a Brazilian Clinical Setting: Adherence, Adverse Events, Sexual Behavior, and Sexually Transmitted Infections

Cited by 3 publications

References 26 publications

Substance Use and Risky Sexual Behavior in the PrEP Outpatient Clinic at the University Hospital of Brasília

Substance Use and Risky Sexual Behavior in the PrEP Outpatient Clinic at the University Hospital of Brasília

"I Can’t Take This Shitty Quarantine Anymore": Sexual Behavior and PrEP Use Among Young Men Who Have Sex with Men and Transgender Women in Brazil During the COVID-19 Pandemic

Fractional order modeling for injectable and oral HIV pre-exposure prophylaxis

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