HIV Type 2 Can Bind to CD8 Molecules but Does Not Infect CD8+ T Cells

Ichiyama, Kouji; Akimoto, Hiroaki; Neoh, Lian Pin; Takeda-Hirokawa, Nanako; Kaneko, Hiroshi; Hishikawa, Takashi; Hashimoto, Hiroshi; Hirose, Shunichi; Kaneko, Yutaro; Yamamoto, Naoki; Sekigawa, Iwao

doi:10.1089/088922299311006

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Pathogenesis and Immune Response1

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2002

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“…The overproduction of β chemokines by PBMCs from HIV-2-infected donors can prevent infection of R5 tropic (see below) HIV-1 strains in vitro (Kokkotou et al ., 2000 ). Furthermore, HIV-2 (but not HIV-1) Env protein can interact with CD8 on T cells that are non-permissive to infection, triggering the production of β chemokines (Akimoto et al ., 1998 ; Ichiyama et al ., 1999 ). Higher proportions of CD8 + T cells from HIV-2-infected individuals retain the ability to simultaneously produce the cytokines IL-2 and IFN- γ.…”

Section: Pathogenesis and Immune Responsementioning

confidence: 99%