HLA-A -B and -DRB1 distribution in Kami: A caste population of Gorkha community from the sub-Himalayan region of West Bengal, India

Singh, Bisu; Chamlagai, Dependra; Gurung, Jiwan

doi:10.1016/j.humimm.2020.06.007

Cited by 1 publication

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“…The HLA profile of the Kami population has been reported by the authors elsewhere [4]. The present study is the first of its kind to study the genetic affinity of the Indian Kami population based on the HLA profile.…”

Section: Discussion/conclusionmentioning

confidence: 70%

“…The study was approved by the Institutional Ethical Committee, Sikkim University. Genomic DNA isolation was carried out by using a kit from Qiagen, and the first field resolution of HLA-A, -B and -DRB1 typing and genotype assignment were performed as described elsewhere [4]. The HLA genotype data of the comparator populations were obtained from the http://www.allelefrequencies.net database and the following publication on Kannada, Malayalam, Tamil, Telugu, Tulu [5], Indian Bengalis [6], Iranian Kurds [7], Nepalese [8], Pakistan Gujjar [9] and Lebanese [10].…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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HLA Profile of Kami Population Refutes the Earlier Proposition of Exclusive Closer Genetic Affinity of All the Gorkhas to Mongoloids

2020

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Objective: Based on the HLA profile of Indian Gorkhas, Debnath and Chaudhuri (2006) proposed that Gorkhas are genetically closer to Mongoloids, and they may have originated from Mongolians or Tibetan stocks. However, the major limitation of the earlier study was that Gorkhas comprise 2 broad groups, i.e. Tibeto-Burmans and Indo-Aryans. Besides, Gorkhas have an assemblage of many sociocultural and linguistically distinct populations such as Rai, Magar, Limbu, Tamang, Newar, Bahun, Kami, and so on. Thus, the generalization of the findings on Gorkhas by considering them as a single homogenous population may not be free from biases. Therefore, the present study aims to understand the genetic affinity of a constituent population from the Gorkha community, i.e. Kami, based on HLA polymorphism. Methods: First field HLA typing was performed among 158 Kami individuals by PCR-SSP methods. Results: The most frequent genes observed were HLA-A*11, HLA-B*15, HLA-DRB1*15. The frequency of HLA-DRB1*15 reported here is the highest recorded among the North Indian population to date, which is a noteworthy finding of the study. The hierarchical cluster analysis and principal component analysis showed that the Kami population lies within the cluster of the Indian subcontinental population. Conclusion: The study refutes the earlier proposition of exclusive belongingness of all the Gorkhas to Mongoloids.

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Section: Discussion/conclusionmentioning

confidence: 70%