HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry

Kwok, Janette; Guo, Mengbiao; Yang, Wanling; Lee, C.K.; Chan, Nathaniel K.; Ho, Jenny; Tang, Wai-Kiu; Chan, Y.S.; Middleton, Derek; Lu, Liwei; Chan, Godfrey Chi Fung

doi:10.1016/j.humimm.2016.10.006

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…A recent study on 82 Chinese COVID-19 patients from East China suggested HLA-B*15:27 as a susceptibility marker. 5 This allele has a frequency of 0.46% in the HKCCBR 7 and was absent in our COVID-19 patients and HKRCBTS blood donors, the majority of whom are southern Chinese. HLA-B*46:01 was recently predicted by in silico studies to have the fewest binding peptides for SARS-CoV-2 and thus expected to confer disease susceptibility.…”

mentioning

confidence: 66%

“…COVID‐19 disease severity was classified as mild/moderate, severe or critical as previously described 6 . For control comparison, we obtained genotyping data of 3892 unrelated ethnic Chinese in the Hong Kong Chinese Cord Blood Registry (HKCCBR) from the Allele Frequency Net Database (AFND) 7,8 . This study was approved by the Joint CUHK‐NTEC Clinical Research Ethics Committee and carried out following the Declaration of Helsinki.…”

Section: Serotype Covid‐19 Patients (N = 190) Hkccbr (N = 3892mentioning

confidence: 99%

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Association of HLA‐B22 serotype with SARS‐CoV‐2 susceptibility in Hong Kong Chinese patients

Yung

Cheng

Chan

et al. 2020

HLA

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The coronavirus disease 2019 (COVID‐19) is a highly infectious disease caused by SARS‐CoV‐2. Since its first report in December 2019, COVID‐19 has evolved into a global pandemic causing massive healthcare and socioeconomic challenges. HLA system is critical in mediating anti‐viral immunity and recent studies have suggested preferential involvement of HLA‐B in COVID‐19 susceptibility. Here, by investigating the HLA‐B genotypes in 190 unrelated Chinese patients with confirmed COVID‐19, we identified a significant positive association between the B22 serotype and SARS‐CoV‐2 infection (p = 0.002, Bonferroni‐corrected p = 0.032). Notably, the B22 serotype has been consistently linked to susceptibility to other viral infections. These data not only shed new insights into SARS‐CoV‐2 pathogenesis and vaccine development but also guide better infection prevention/control.

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mentioning

confidence: 66%

Section: Serotype Covid‐19 Patients (N = 190) Hkccbr (N = 3892mentioning

confidence: 99%

Association of HLA‐B22 serotype with SARS‐CoV‐2 susceptibility in Hong Kong Chinese patients

Yung

Cheng

Chan

et al. 2020

HLA

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“…The characteristics of the present study population have been described previously (Kwok et al, ). Briefly, the current population of Hong Kong comprises 91% of people of Chinese descent (http://www.gov.hk/en/about/abouthk/facts.htm; retrieved 5/07/17).…”

Section: Methodsmentioning

confidence: 99%

A study of human neutrophil antigen genotype frequencies in Hong Kong

Tam

Tang

et al. 2017

Transfusion Medicine

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This is the first study to define HNA genotype and allele frequencies using a validated modified in-house PCR-SSP method in the Hong Kong Chinese blood donor population. Our approach provides a cost-effective assay for conducting routine HNA typing and facilitates the incorporation of these assays into routine clinical service. Our results are comparable with those reported in the Guangzhou Chinese population, but the allele frequencies in our Hong Kong Chinese population are significantly different from the reported European frequencies, confirming that a geographical difference exists for HNA allele frequencies.

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“…34,35 With a population of 7.3 million (91.6% were Chinese), over 95% of the kidney donor pool in the ORTS of Hong Kong are of Chinese ethnicity, and due to such ethnic predominance the HLA allele/haplotype frequencies differ significantly from other populations and transplant programs. 29,[36][37][38][39][40] Add to that, the phenotypic frequency…”

Section: Discussionmentioning

confidence: 99%

ABO‐adjusted cPRA metric for kidney allocation in an Asian‐predominant population

Lau,

Chu,

Tang

et al. 2023

HLA

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Recent studies showed that ABO‐adjusted calculated panel reactive antibody (ABO‐cPRA) may better reflect the histocompatibility level in a multi‐ethnic population, but such data in Asians is not available. We developed an ABO‐adjusted cPRA metric on a cohort of waitlist kidney transplant patients (n = 647, 99% Chinese) in Hong Kong, based on HLA alleles and ABO frequencies of local donors. The concordance between the web‐based ABO‐cPRA calculator and the impact on kidney allocation were evaluated. The blood group distribution for A, B, O and AB among waitlist kidney candidates were 26.2%, 27.5%, 40.1%, and 6.1%, and their chances of encountering incompatible blood group donors were 32.6%, 32.4%, 57.6%, and 0%, respectively. There is poor agreement between web‐based ABO‐cPRA calculator and our locally developed metrics. Over 90% of patients showed an increase in cPRA after ABO adjustment, most notably in those with cPRA between 70% and 79%. Blood group O patients had a much greater increase in cPRA scores after adjustment while patients of blood group A and B had similar increment. 10.6% of non‐AB blood group waitlist patients had ABO‐cPRA elevated to ≥80%. A local ABO‐adjusted cPRA metric is required for Asian populations and may improve equity in kidney distribution for patients with disadvantageous blood groups. The result from the current study potentially helps other countries/localities in establishing their own unified ABO‐cPRA metrics and predict the impact on kidney allocation.

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HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry

Cited by 6 publications

References 7 publications

Association of HLA‐B22 serotype with SARS‐CoV‐2 susceptibility in Hong Kong Chinese patients

Association of HLA‐B22 serotype with SARS‐CoV‐2 susceptibility in Hong Kong Chinese patients

A study of human neutrophil antigen genotype frequencies in Hong Kong

ABO‐adjusted cPRA metric for kidney allocation in an Asian‐predominant population

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