HLA and multiple sclerosis in south east Wales.

Abstract

results in 600 (HLA-A and -B) and 407 (HLA-DR and -DQ) randomly selected local caucasoid controls. All antigen assignments were made without prior knowledge of the disease status. The significance of associations between multiple sclerosis and particular phenotypes was examined using the chi-square test and relative risks (RR) with 95% confidence limits were calculated. Lastly, correlation coefficients between specific antigen frequencies and prevalence were computed. ResultsThere was an increased frequency of HLA-A3 (26 3% vs 24-3%:ns), -B7 (40 4% vs 28-2%:ns) and -DR2 (50 7% vs 26-5%:p < 0-001) in patients compared with controls (table 1). A similar trend was observed comparing the frequencies of HLA-DQwl in patients (n = 45, 71 1%) and controls (59%) but this was not statistically significant. The relative risk for developing multiple sclerosis in the presence of HLA-DR2 or -DQwI was 2-87 (95% confidence interval 1-66-4-98) and 1-7 (95% confidence interval 0-88-2-21) respectively. Previously published antigen frequencies and statistics for north east Scotland' are also shown in table 1. Table 2 shows the relative risk for developing multiple sclerosis in south east Wales in the presence of different combinations of class two antigens. Table 3 shows the relationship between the frequency of HLA-DR2 and -DQwI in patients and controls together with prevalence of multiple sclerosis in areas where all three variables have been studied. Although the prevalence of multiple sclerosis correlates directly with normal variations in the frequency of HLA-DR2 (r = 0-952) and -DQwl (r = 0 955) there are too few observations to achieve statistical significance.

Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

“…In Arabian (38) as well as in Sardinian (39) MS patients an association with the DR4 antigen has been found. A weak association with the DQwl antigen (DR2 associated) was found in Scottish MS patients (11), but this finding has not been confirmed (12,40). An association with the DPw4 specificity has been reported in Swedish MS patients (41).…”

Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland

“…HLA heterogeneity for susceptibility to MS has been demonstrated in other populations [1,10]. Previous studies have shown the strong association between the carriage of the DRB1*1501 -DQB1*0602 haplotype and the development of MS in the Northeast of Ireland and south east Wales in MS patients relative to controls [2,11,17]. The association with this haplotype was demonstrated in all clinical subtypes of MS within the Northern Irish community [11].…”

Hacia la búsqueda de dimensiones más específicas en la medición de la calidad de vida en la esclerosis múltiple

“…Los neurólogos nos remitieron a los pacientes, atendiendo a una distribución condicionada por las diferentes formas de presentación de la evolución de la enfermedad en el ámbito poblacional, con el fin de obtener una muestra representativa, según lo manifestado en los diferentes estudios epidemiológicos [4][5][6][7][8][9][10][11][12][13][14][15][16].…”

“…La esclerosis múltiple (EM) es una enfermedad con importantes consecuencias psicológicas y sociales para las personas que la padecen, dado que tiene un carácter impredecible en su evolución crónica [1][2][3]. Dichas consecuencias producen repercusiones en el ámbito poblacional, por ser una enfermedad prevalente en los adultos jóvenes de los países desarrollados [4][5][6][7][8][9][10][11][12][13][14][15][16], y limitar los años más productivos de este sector de la población (en el ámbito laboral, familiar y social) [17]. Estas características provocan que los pacientes con EM padezcan no sólo secuelas físicas, sino también problemas sociales y psicológicos [18].…”