HLA and uveitis

Feltkamp, T. E. W.

doi:10.1007/bf00163552

Cited by 21 publications

(11 citation statements)

References 8 publications

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“…(Careless & Inman 1995) Such phenomenon was noted, for example, in K. pneumoniae. (Feltkamp 1990;Geczy & Yap 1979) It may be a cause of the cross-reaction (involving T lymphocytes) which, in response to bacterial antigens, may stimulate the production of antibodies that cross-react with HLA-B27 antigen of the host. Theoretically, this process could also promote the long-term survival of pathogens in host tissues because of cross-tolerance between the bacterial antigens and the host's HLA system.…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, this process could also promote the long-term survival of pathogens in host tissues because of cross-tolerance between the bacterial antigens and the host's HLA system. (Feltkamp 1990) According to another hypothesis, HLA-B27 acts like an alternative receptor which specifically reacts with some bacterial antigens and in this way modulates the response to infection. (Careless & Inman 1995) Analysing our data, we found a tendency towards slightly greater levels of anti-LPS antibodies in HLA-B27-positive patients than in HLA-B27-negative ones, but the observed differences were not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous investigations indicate a significant role of HLA-B27 antigen as a factor predisposing to AAU (Chang et al 2005;Careless & Inman 1995). According to Feltkamp, the presence of HLA B27 increases eight times the relative risk of acquiring AAU (Feltkamp 1990). Some authors stress that having the antigen may be connected with a more severe course of the disease and a more serious prognosis, which in such cases is often characterized by unilateral recurrences, and it is even suggested to treat so-called HLA-B27-positive AAU as a separate clinical entity (Chang et al 2005;Rothova et al 1987;Power et al 1998).…”

Section: Introductionmentioning

confidence: 99%

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Elevated levels of anti‐endotoxin antibodies in patients with bilateral idiopathic acute anterior uveitis

Misiuk-Hojło

Międzybrodzki

Grzybowski³

et al. 2011

Acta Ophthalmologica

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ABSTRACT.Purpose: Endotoxins have been proved to be responsible for acute anterior uveitis (AAU) in animals in a well-established experimental model of endotoxin-induced uveitis (EIU). The purpose of our study was the detection of antibodies against endotoxins of selected enterobacteria in the serum of patients with idiopathic AAU and searching for correlations between the levels of these antibodies and the presence of HLA-B27 antigen as well as characteristic signs of EIU such as bilaterality and the absence of spontaneous recurrences of the disease. Methods:Reactions of serum IgG antibodies with lipopolysaccharides (LPSs) of Escherichia coli O1, E. coli O10, E. coli O111, E. coli J5, and Klebsiella pneumoniae O3 were determined for 60 patients with idiopathic AAU and 40 healthy volunteers. The presence of HLA-B27 antigen in patients was determined. Documentation of the frequency of recurrences of AAU during a follow-up period of 8 years was collected.Results: We have observed that the sera of patients with a first attack of AAU reacted stronger with the LPS of K. pneumoniae O3 than the sera of patients with relapse of the disease. Patients with bilateral AAU had markedly higher levels of antibodies against four of the five used LPSs than patients with one eye involved. A multiply comparison showed higher levels of IgG reacting with LPS of E. coli O111 in patients with bilateral eye inflammation admitted with the first attack of AAU comparing to controls. The incidence of recurrent form of AAU was significantly increased in HLA-B27-positive patients compared to HLA-B27-negative patients. However, we found in HLA-B27 carriers that those with the bilateral form of AAU had over three times smaller risk of recurrence and showed stronger immunization by endotoxins than patients with unilateral inflammation. Conclusion:Our results suggest a potential role of endotoxins in the aetiology of the nonrecurrent bilateral form of AAU. We suggest that not only HLA-B27 status but also determination of number of involved eyes may be useful to assess the risk of recurrence of the idiopathic AAU.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Elevated levels of anti‐endotoxin antibodies in patients with bilateral idiopathic acute anterior uveitis

Misiuk-Hojło

Międzybrodzki

Grzybowski³

et al. 2011

Acta Ophthalmologica

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“…Previous studies of AMA isotype distribution showed that AMA are mainly in the IgG3 and IgM fractions [12][13][14]. These studies used four anti-human IgG subclass-specific MoAbs.…”

Section: Introductionmentioning

confidence: 99%

Anti-mitochondrial antibody IgG subclass distribution and affinity in primary biliary cirrhosis

Zhang

Weetman

Jayne

et al. 1992

Clinical and Experimental Immunology

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SUMMARYWe have studied the total IgG subclass and anti-mitochondrial antibody (AMA) specific IgG subclass distribution in primary biliary cirrhosis (PBC) sera. In order to solve the problems caused by thc differing affinities of subclass specific monoclonals and the competitive inhibition of antibodies in a whole serum assay. si.\ sera were separated into su be I ass-specific fractions by affinity-depletion chromatography. AMA subclass distribution of 20 further sera from patients with PBC was assessed using conventional methods and thercsultswerecalibratedagainst one of the fractionated sera. Light chain distribution and AMA functional affinity were also assessed for the fractionated subclasses. Total amounts of !gG3 were significantly increased compared with normal controls, AMA were found in all IgG subclasses and not restricted predominantly to lgG3 as previously described. The functional affinity of lgG3 AMA is generally lower as compared with that of other subclasses. No light chain restriction was found.

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“…4 The probability of diagnosis of BSRC rises from 70 to 97% in HLA A-29 positive patients and decreases to 7.0% to 8.5% in HLA A29 negative patients. 5 Both HLA A29.1 and HLA A29.2 are associated with this ocular inflammatory disease. However, the presence of HLA-A29 does not imply that the patient will definitely develop BSRC.…”

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confidence: 98%