HLA antigens in ulcerative colitis: a study in the Sicilian population

Caruso, Calogero; Palmeri, Patrizia; Oliva, L; Orlando, Ambrogio; Cottone, Mario

doi:10.1111/j.1399-0039.1985.tb00411.x

Cited by 26 publications

References 9 publications

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Genetic predispositions for the immunological features of chronic active hepatitis

Czaja¹,

Carpenter²,

Santrach³

et al. 1993

Hepatology

122

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To assess the frequency and genetic predispositions of concurrent immunological diseases and immunoserological markers in autoimmune hepatitis and chronic viral hepatitis, we assessed 185 patients prospectively, including 122 patients with autoimmune hepatitis and 63 patients with viral disease. Human leukocyte antigens were determined in all patients. Sixty patients (32%) had concurrent immunological diseases, and the majority of the diseases (68%) had known human leukocyte antigen associations. Although patients with autoimmune hepatitis had concurrent immunological diseases more commonly than those with viral disease (38% vs. 22%; p = 0.04), the nature of the diseases was similar in both groups, as were the frequencies of human leukocyte antigen-DR4 (42% vs. 39%; p = 0.7). The presence of human leukocyte antigen-DR4 was associated with the concurrence of immunological diseases in both autoimmune (62% vs. 33%; p = 0.01) and viral hepatitis (75% vs. 29%; p = 0.009). In autoimmune hepatitis, human leukocyte antigen-DR4 was also associated with the expression of smooth muscle antibodies and high-titer antinuclear antibodies. We conclude that concurrent immunological diseases and immunoserological markers are common in autoimmune and chronic viral hepatitis. Both conditions have a common genetic predisposition for concurrent immunological disease associated with human leukocyte antigen-DR4. The expression of smooth muscle antibodies and high-titer antinuclear antibodies is associated with human leukocyte antigen-DR4 in autoimmune hepatitis only, suggesting that this response is associated with triggering antigens and immune recognition systems that are different from those in viral disease.

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Genetic predispositions for the immunological features of chronic active hepatitis

Czaja¹,

Carpenter²,

Santrach³

et al. 1993

Hepatology

122

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Genetics of inflammatory bowel disease

Duerr

1996

Inflamm Bowel Dis

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: Genetic influence in the susceptibility to inflammatory bowel disease (IBD) is suggested by racial, ethnic, and familial aggregation of disease. Increased concordance for IBD in monozygotic compared with dizygotic twins suggests that genetic rather than environmental factors are primarily responsible for the familial aggregation. A dramatically increased risk for IBD in siblings compared with spouses of affected individuals and many instances of temporal and geographic separation of disease onset in affected relatives also suggest that the familial aggregation of IBD is primarily due to genetic factors. The complex genetics of IBD involves incomplete penetrance and probably involves oligogenic inheritance and genetic heterogeneity. Identification of subclinical markers and markers of genetic heterogeneity in IBD to address the likely problems of incomplete penetrance and genetic heterogeneity would greatly simplify the task of finding IBD susceptibility loci in well-designed genetic marker association and linkage studies. Potential subclinical markers and markers of genetic heterogeneity in IBD are reviewed, as are candidate-gene studies. In addition to candidate-gene studies, future studies should include whole genome screening by using polymorphic genetic markers throughout the genome systematically to map IBD-susceptibility loci. Currently available molecular biologic technology with highly informative polymorphic genetic markers should permit successful identification of IBD-susceptibility genes.

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Class II HLA Antigens in Autoimmune and Immune-Mediated Diseases

Jeannet¹

1986

HLA Class II Antigens

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HLA antigens in ulcerative colitis: a study in the Sicilian population

Cited by 26 publications

References 9 publications

Genetic predispositions for the immunological features of chronic active hepatitis

Genetic predispositions for the immunological features of chronic active hepatitis

Genetics of inflammatory bowel disease

Class II HLA Antigens in Autoimmune and Immune-Mediated Diseases

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