HLA‐B27 polymorphism in the Malays

Dhaliwal, Jasbir; Too, Chun-Lai; Lisut, M.; Lee, Y.Y.; Murad, Shahnaz

doi:10.1034/j.1399-0039.2003.00107.x

Cited by 22 publications

(24 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our observations are consistent with HLA data obtained from previous studies on the Malays [13][14][15][16][17], which corroborate historical data, archaeological evidence, linguistic, and mtDNA studies reported previously [4 -12]. Further studies on the HLA of other Malay subethnic groups in the Malay Archipelago should therefore clarify the origin and genetic relationships between them, as well as with other world populations.…”

Section: Discussionsupporting

confidence: 92%

HLA polymorphism in six Malay subethnic groups in Malaysia

et al. 2009

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

HLA polymorphism in six Malay subethnic groups in Malaysia

et al. 2009

View full text Add to dashboard Cite

“…Such information is helpful for identifying the differences thay may lead to better understanding of disease mechanisms. [13][14] HLA has an important role in population genetics, donor selection for organ transplantation, paternity determination, various infectious and autoimmune diseases association, clinical utility in understanding drug reactions (antiretroviral, antiepileptic etc). Overall biological relevance to adaptive immunity and vaccine development demands extensive knowledge of HLA variations among populations.…”

Section: Introductionmentioning

confidence: 99%

Human Leukocyte Antigen: Class I Allele Frequencies and Haplotype Distributionin a Tertiary Care Hospital in Bangladesh

Sultana

Tabassum

Nessa

2018

Bangladesh Med Res Counc Bull

View full text Add to dashboard Cite

Human leukocyte antigen (HLA) are cell surface glycoproteins encoded by Major Histocompatibility Complex (MHC) gene of human genome. HLA antigen frequency and haplotype distribution are useful for determining disease association, origin, migration and genetic relationship between populations and predicting the outcome of transplantation. Thus, the present study was carried out to identify HLA class I (HLA-A and HLA-B) antigen and haplotype distribution among a selected Bangladeshi population. This retrospective study was conducted among 1070 individuals, who were referred by clinicians for HLA typing at the Tissue Typing Laboratory of the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU) during the period 2009 to 2011. For HLA typing, blood was collected in heparin containing tube and the laboratory tests were performed by the microlymphocytotoxicity technique according to manufacturer's instructions. Out of 19 HLA-A and 37 HLA-B antigens tested, a total of 19/19 and 36/37 antigens were detected respectively in this study. The most frequent antigens of HLA-A and HLA-B detected were A11 (25.4%), A24 (16.6%), B75 (18.1%) and B35 (11.3%). The least antigen frequency detected for HLA-A locus were A69 (0.09%), A26 (0.28%), A34 (0.28%), while for HLA-B locus were B81 (0.09%) and B56 (0.09%). Among the HLA-A and HLA-B antigens, some alleles were found to be homozygote such as A11 (4.0%), A2 (2.7%), A24 (2.1%) and B75 (2.4%), B35 (1.8%), and B44 (1.4%) respectively. The most frequent haplotype in the study population were A11: B75 (4.9%). The most frequent antigens of HLA-A and HLA-B detected were A11 (25.4%), B75 (18.1%) respectively. The distribution of HLA haplotypes among the study population indicates that it has the influence of Oriental and Asian populations. Thus, this study will be helpful to provide valuable information for population genetics and HLA disease association analysis.

show abstract

“…It was found that the frequency of B*27 corresponds to the incidence of AS in the worldwide population. It is clearly a risk factor attributed to the susceptibility of the disease and proven to be a useful genetic marker for the diagnosis of the disease (Gonzalez‐Roces et al ., 1997; Feltkamp et al ., 2001; Dhaliwal et al ., 2003; Yang et al ., 2004; Park et al ., 2008). Naturally, discovery of a new B27 allele extends a kin interest on its likely association with AS.…”

Section: Introductionmentioning

confidence: 99%

Detection of a novel HLA‐B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence‐based typing: curiosity rewarded

Chen¹,

Yang²,

Chu³

et al. 2009

Int J Immunogenetics

View full text Add to dashboard Cite

We report here a novel HLA-B allele, B*2740, discovered in Taiwanese volunteer marrow donors. The new sequence has nucleotide variation at position 527 (T-->A) as compared to B*2708. The nucleotide change caused an amino acid substitution from valine (V) to glutamic acid (E) at codon 152. Since B*2740 carries sequence confers to HLA-Bw6 public epitope we believe that this novel B*27 allele might have been generated from a gene conversion involving a Bw4-specific allele (probably B*2704) and a Bw6-specific allele.

show abstract

HLA‐B27 polymorphism in the Malays

Cited by 22 publications

References 15 publications

HLA polymorphism in six Malay subethnic groups in Malaysia

HLA polymorphism in six Malay subethnic groups in Malaysia

Human Leukocyte Antigen: Class I Allele Frequencies and Haplotype Distributionin a Tertiary Care Hospital in Bangladesh

Detection of a novel HLA‐B27 allele, B*2740, in Taiwanese volunteer bone marrow donors by sequence‐based typing: curiosity rewarded

Contact Info

Product

Resources

About