HLA-B35, a common genetic trait, in a familial case of Henoch-Schoenlein purpura and Berger's disease

Abstract

ABSTRACT. Nephritis characterized by IgA mesangial depositions has been described both in Henoch-Schoenlein purpura (HSP) and in Berger's disease (BD), but common genetic traits are still uncertain. We report here the case of two brothers, the first affected by HSP with persistent nephritis and the second by BD, accidentally discovered as silent microhematuria 1 year after HSP onset in the first brother. HLA genotyping demonstrated the presence of HLA-B35 in both patients. Our findings reinforce the need to screen for urinary abnormalities in family members of patients affected by HSP nephritis to identify a silent IgA nephropathy.

Kidney involvement in adults with IgA vasculitis: experiences from Clinical Hospital Dubrava, Zagreb

“…najvjerojatnije se radi o interakciji genskih i vanjskih čimbenika, što pokreće stvaranje imunosnih kompleksa antigen -protutijelo, uz razvoj imunosno posredovane upale stijenke malih krvnih žila (5). veću vjerojatnost za razvoj IgA-vaskulitisa pokazuju bolesnici nositelji određenih antigena hlA: hlA-drb1 01, hlA-b41:02 i hlA-b35 (6,7). najčešći vanjski čimbenici koji se povezuju s nastankom bolesti u djece jesu uzročnici infekcija gornjeg i donjega dišnog sustava kao što su streptokoki, stafilokoki te virus parainfluence (8).…”

“…It is most likely an interaction of genetic and external factors, which triggers the formation of antigen-antibody immune complexes, with the development of immune-mediated inflammation of the wall of small blood vessels (5). Patients carrying certain hlA antigens are more likely to develop IgA vasculitis: hlA-drb1:01, hlA-b41:02 and hlA-b35 (6,7). The most common external factors associated with the occurrence of the disease in children are the causes of upper and lower respiratory tract infections such as streptococci, staphylococci, and parainfluenza viruses (8).…”

The HLA-B*35 allele modulates ER stress, inflammation and proliferation in PBMCs from Limited Cutaneous Systemic Sclerosis patients

“…HLAB*35 was also associated with SSc in a Choctaw Indian tribe with increased prevalence of SSc [ 7 ]. Furthermore, the association between HLA-B*35 and various other disorders as well as severe viral infections has been reported [ 6 – 9 ]. In particular, studies in patients with HIV (human immunodeficiency virus) infection from different geographical areas have shown a correlation between HLA-B*35 phenotype and progression of AIDS (Acquired Immune Deficiency Syndrome) [ 10 – 12 ].…”