HLA Bw51 is increased in mucocutaneous lymph node syndrome in Israeli patients

Keren, G; Danon, Yehuda L.; Orcad, Shlomit; Kalt, Rivka; Gazit, Ephraim

doi:10.1111/j.1399-0039.1982.tb00337.x

Cited by 23 publications

(9 citation statements)

References 5 publications

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“…No association with HLA-Bw22 or class II antigens was observed in children with KD in the United States [13][14][15] or Hong Kong [17]. However, a significant association was present for HLA-Bw51 in the United States [13,14] and Israel [12]. More recent genetic studies based on modern HLA typing techniques have failed to demonstrate an association between KD and particular HLA class II alleles in Caucasians [18,19].…”

Section: Discussionmentioning

confidence: 86%

Genetic Variations of HLA-DRB1 and Susceptibility to Kawasaki Disease in Taiwanese Children

et al. 2007

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Section: Discussionmentioning

confidence: 86%

Genetic Variations of HLA-DRB1 and Susceptibility to Kawasaki Disease in Taiwanese Children

et al. 2007

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“…As a result of their involvement in immune response, HLA genes have been extensively studied in association with outcomes of autoimmune and infectious diseases. Unlike in other diseases, the role of HLA genes in relation to KD has not been well defined, although a few early reports exist (Fildes et al , 1992; Huang et al , 2007; Kaslow et al , 1985; Kato et al , 1978; Keren et al , 1982; Krensky et al , 1981; Krensky et al , 1983; Matsuda et al , 1977; Oh et al , 2008). Recently, we replicated findings from GWA studies showing an association between a SNP (rs2857151) in HLA Class II region and KD susceptibility (Shendre et al , 2014).…”

Section: Introductionmentioning

confidence: 99%

Imputation of class I and II HLA loci using high‐density SNPs from ImmunoChip and their associations with Kawasaki disease in family‐based study

Shrestha

Wiener

Aissani

et al. 2015

Int J Immunogenetics

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Summary Kawasaki disease (KD) is the leading cause of acquired heart disease in children in most developed countries including the United States. The etiology of KD is not known; however, epidemiological and immunological data suggest infectious or immune-related factors in the manifestation of the disease. Further, KD has several hereditary features that strongly suggest a genetic component to disease pathogenesis. Human leukocyte antigen (HLA) loci have also been reported to be associated with KD but results have been inconsistent, in part, because of small study samples and varying linkage disequilibrium (LD) patterns observed across different ethnic groups. To maximize the informativeness of single nucleotide polymorphism (SNP) genotypes in the major histocompatibility (MHC) region, we imputed classical HLA I (A, B, C) and HLA II (DRB1, DQA1, DQB1) alleles using SNP2HLA method from genotypes of 6700 SNPs within the extended MHC region contained in the ImmunoChip among 112 white KD patients and their biological parents from North America and tested their association with KD susceptibility using the transmission disequilibrium test. Mendelian consistency in the trios suggested high accuracy and reliability of the imputed alleles (class I=97.5%, class II=96.6%). While several SNPs in the MHC region were individually associated with KD susceptibility, we report over-transmission of HLA-C*15 (z=+2.19, P=0.03) and under-transmission of HLA-B*44 (z=−2.49, P=0.01) alleles from parents to KD patients. HLA-B*44 has been associated with KD in other smaller studies and both HLA-C*15 and HLA-B*44 have biological mechanisms that could potentially be involved in KD pathogenesis. Overall, inferring HLA loci within the same ethnic group, using family based information is a powerful approach. However, larger families are warranted to evaluate the correlations of the strength and directions between the SNPs in MHC region and the imputed HLA alleles with KD.

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“…In Japanese Implementation of personalized medicine for KD A Hata and Y Onouchi KD patients, HLA-Bw22 (now referred to as Bw54) is reported to be predominant. 24,25 On the other hand, HLA-Bw51 was found to be associated with Caucasian 26,27 and Jewish KD patients, 28 but no replication was obtained in Chinese 29 and Korean KD patients. 30 Although several other groups have studied other combinations of HLA subtypes, no consistent association has been detected so far.…”

Section: Candidate Gene Approachmentioning

confidence: 96%

Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine

Hata

Onouchi

2009

J Hum Genet

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Kawasaki disease (KD) is an acute systemic vasculitis syndrome, which primarily affects in children under the age of 5 years. In 20-25% of cases, if untreated, coronary artery lesions develop, making KD the leading cause of acquired heart disease in children in both Japan and the United States. Since 1970, 19 nationwide surveys of KD in Japan have been conducted every 2 years and the data are stored in a database. Even though the etiology of KD remains unknown, despite enthusiastic research spanning more than 40 years, we have learnt a great deal about KD from this enormous database. These 19 epidemiologic studies indicate a strong genetic influence on the disease susceptibility, prompting us and other researchers to identify the responsible genes for KD by applying either the candidate gene approach or the genome-wide approach. We have employed a genome-wide linkage study using affected sibling pair data of KD in Japan and have identified several susceptibility loci. Further analysis focusing on a region of chromosome 19, where one of the linked loci was detected, identified a predisposing gene, which codes inositol 1,4,5-trisphosphate 3-kinase C (ITPKC). In this review, we summarize the cumulative knowledge regarding KD, and then outline our hypothesis of the role ITPKC plays in KD susceptibility and our trial that aims toward the implementation of personalized medicine for KD.

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HLA Bw51 is increased in mucocutaneous lymph node syndrome in Israeli patients

Cited by 23 publications

References 5 publications

Genetic Variations of HLA-DRB1 and Susceptibility to Kawasaki Disease in Taiwanese Children

Genetic Variations of HLA-DRB1 and Susceptibility to Kawasaki Disease in Taiwanese Children

Imputation of class I and II HLA loci using high‐density SNPs from ImmunoChip and their associations with Kawasaki disease in family‐based study

Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine

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