HLA class II, MICA and PRL gene polymorphisms: the common contribution to the systemic lupus erythematosus development in Czech population

Abstract

ObjectiveThe genetic components contribute to the Systemic lupus erythematosus development. This study for the first time determined the distribution of the polymorphisms and linkage disequilibrium in HLA class II, MICA and PRL gene among patients suffering from SLE and healthy Czech individuals. Patients and Methods DNA ConclusionHLA class II-MICA combinations may increase/decrease a risk for SLE development.Multiple studies focusing on the ethnical differences as well as genetic-epigenetic relationships are necessary for better understanding SLE pathogenesis.

Nerve growth factor receptor expression in lymphocytes: Comment on the article by Raychaudhuri et al

“…In contrast to the authors' findings on T cells, we could not detect any influence of NGF on NK cell proliferation, and NGF also did not support the survival of NK cells (2). In addition, NGF did not modulate cytotoxicity and cytokine production by NK cells, although we only tested for interferon-␥ and IL-10.…”

“…Furthermore, we have recently shown that ϳ20% of freshly isolated NK cells from mouse spleens express TrkA, but that this percentage increases to 100% after a few days of culture in the presence of interleukin-2 (IL-2) (2). Similar to T cells (1), the subset of NK cells expressing the neurotrophin receptor p75 NTR is extremely low (2).…”

“…The discrepancy may possibly be attributable to the distinct characteristics of patients. For example, in the Czech population, the frequency of the MICA A9 allele was higher in SLE patients with skin involvement than in patients without this manifestation (16.6% versus 7.7%) (2). Another explanation may be the differences in the ethnic groups studied and the criteria used for selection of patients and healthy controls.…”

“…Some studies revealed a relationship between MICA A5/A5.1 polymorphisms and susceptibility to SLE (2,3), while no such relationship between the MICA A9 allele and SLE was observed in a different population (2,4). However, Gambelunghe et al (3) demonstrated that the MICA A9 allele was negatively associated with the disease (odds ratio 0.2, corrected P Ͻ 0.0005) in Italian patients with SLE, showing that the MICA A9 allele might be a protective allele in the pathogenesis of SLE.…”

Polymorphisms in HLA-DRB1 Gene and the Risk of Tuberculosis: A Meta-analysis of 31 Studies

“…T cells play a central role in immune protection which recruits neutrophils, eosinophils, and basophils to sites of infection and inflammation, to help B cells make antibodies, to induce macrophages to develop enhanced microbicidal activity, and through their production of cytokines and chemokines, to orchestrate the full panoply of immune responses [7]. Thereby, lot of studies demonstrated that there is close relationship between the HLA gene polymorphisms and infection disease, cancer, inflammatory, and autoimmune disease [8][9][10][11][12][13]. In addition, growing studies found that the HLA Class II gene, especially HLA-DRB1 gene polymorphisms, might significantly influence of TB risk [14][15][16], but the results have been inconclusive.…”