HLA Class II Polymorphism in Egyptian Children with Lymphomas

Al‐Tonbary, Youssef; Abdel-Razek, N.; Zaghloul, Hesham; Metwaly, Sameh AbdEl-Azeem; El-Deek, Basem; El-Shawaf, R.

doi:10.1080/1024533042000205487

Cited by 16 publications

(13 citation statements)

References 11 publications

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“…DRB1*09 allele in our data is in agreement with significant increase of the DRB1*09 allele in the data from Thai patients with NHL [15]. However, our data is different from the study on Egyptian children patients with NHL, the HLA-DRB1*0403 and DRB1*1301 alleles, and the HLA-DQB1*0501, HLA-DQB1*0201, and HLA-DQB1*0301 alleles were significantly increased while the HLA-DRB1*1302, DQB1*0502, and DQB1*0602 alleles were significantly decreased [16]. This result may suggest that the observed differences in the association of HLA class I and class II antigens between the different studies may be due to the different ethnic groups.…”

Section: Discussioncontrasting

confidence: 85%

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

et al. 2008

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Several studies have been performed on the association between non-Hodgkin's lymphoma (NHL) and the presence of certain human leukocyte antigens (HLA) class II alleles in Asian countries, and these studies have shown different results, according to the ethnicity, for the frequencies of the HLA class II alleles, and especially for HLA-DRB1. Therefore, the distribution of the HLA-A, B, C, DRB1, and DQB1 alleles in 89 Korean patients with NHL and also in 200 healthy Korean controls was investigated in this study. For the class I alleles, the frequencies of HLA-B51 was increased in patients with NHL and diffuse large B cell (DLBC) lymphoma compared with the normal control. For the class II alleles, the frequencies of the HLA-DRB1*09 and DQB1*03 alleles were increased in patients with NHL and DLBC lymphoma compared with the normal controls. Also, the B51-DRB1*09-DQB1*03 haplotype was significantly increased in the patients with NHL. These results suggest that some genes in HLA-B*51-DRB1*09-DQB1*03 haplotype may contribute to NHL susceptibility in the Korean population.

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Section: Discussioncontrasting

confidence: 85%

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

et al. 2008

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“…We found significant increase in the frequency of HLA DRB1*0403 and *1202 and DQ131*0604, *0201 and *0203 alleles which may confer suscepilibity (Al-Tonbary et al, 2004). Similar results were reported by Klitz et al (1994) who reported a significant association of HLA class II alleles with Hodgkin's lymphoma and Harty et al (2002) who reported that the DRB1*1501 allele is related to the development of familial Hodgkin's lymphoma particularly the familial nodular sclerosis type.…”

Section: Familial Incidence and Genetic Susceptibilitysupporting

confidence: 80%

Epidemiology of Hodgkin's Lymphoma

Al‐Tonbary¹

2012

Hodgkin's Lymphoma

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“…In our hospital it was previously reported that HLA-DRB1*03011, HLADRB1*01 and HLA-DRB1*07011 alleles confer susceptibility to poststreptococcal acute glomerulonephritis (Bakr et al 2007), steroid sensitive nephritic syndrome (Bakr et al 1998) and steroid resistant nephrotic syndrome (Bakr et al, 2005), respectively. Similarly HLA-DRB1*0403 & *1301 were associated with non Hodgkin lymphoma and HLA-DRB1*0403 & *1202 alleles were associated with Hodgkin disease in Egyptian children (Al-Tonbary et al, 2004). Moreover HLA-DRB1*04 was found to be significantly associated with hepatocellular carcinoma in Egyptian adults (El-Chennawi et al 2008).…”

Section: Discussionmentioning

confidence: 95%

HLA-DRB1*15 Confers Susceptibility to Juvenile SLE But is Not Associated with Disease Presentation: An Egyptian Study

Mosaad

Hammad

Youssef

et al. 2010

Immunological Investigations

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The etiology of Systemic lupus erythematosus (SLE) seems to be multifactorial including environmental as well as genetic factors. Major histocompatibility complex (MHC) genes especially HLA-DRB1 and HLA-DQB1 are strongly implicated in susceptibility to SLE. Moreover ethnicity has been found to have a significant role in both disease susceptibility and disease expression. This study was carried out to determine HLA-DRB1 allele association with SLE susceptibility and disease presentation in Egyptian children with juvenile onset SLE. HLA-DRB1 allele typing was done using polymerase chain reaction-sequence-specific oligonucleotide probe for 65 juvenile Egyptian SLE patients and 150 healthy controls. p-values were corrected for the number of the alleles tested (Pc). HLA-DRB1*15 g allele was significantly increased in SLE children versus controls (OR = 4.76; 95% CI = 1.83-12.4; p = 0.001 and Pc = 0.012). No HLA-DRB1 allele was found to be statistically significant associated with musculoskeletal, cutaneous, hematologic, cardiac or neuropsychiatric manifestations in SLE patients (p > 0.05). Moreover no statistically significant association was found between HLA-DRB1 alleles and clinical presentation or histologic classes of lupus nephritis. The current work suggests that HLA-DRB1*15g allele may be a susceptibility allele in Egyptian children with SLE but is not related to clinical presentation of SLE.

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HLA Class II Polymorphism in Egyptian Children with Lymphomas

Cited by 16 publications

References 11 publications

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

Association of HLA alleles with non-Hodgkin’s lymphoma in Korean population

Epidemiology of Hodgkin's Lymphoma

HLA-DRB1*15 Confers Susceptibility to Juvenile SLE But is Not Associated with Disease Presentation: An Egyptian Study

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