HLA DR and DQ polymorphism in Ashkenazi and non-Ashkenazi Jews: Comparison with other mediterraneans

Martı́nez-Laso, Jorge; Gazit, Ephraim; Gómez-Casado, Eduardo; Díaz-Campos, Nieves; Vargas‐Alarcón, Gilberto; Morales, Pablo; Martı́nez-Quiles, Narcisa; Álvarez, Miguel A.; Martín-Villa, José Manuel; Fernández, Vı́ctor M.; Arnaiz-Villena, Antonio

doi:10.1016/0198-8859(96)84999-8

Cited by 19 publications

(35 citation statements)

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“…This further stresses that the Jewish genetic background in Ashkenazi, non-Ashkenazi and other Jewish groups have remained stable after their Diasporas (387 years BC and 70 years AD). The same genetic background was found in Central European and Mediterranean Jews by using HLA (histocompatibility antigens) markers (Martínez-Laso et al, 1996). In this paper, we find the same cathepsin C mutations in Spain (Sepharad for the Jews) from which the Jews were expelled in 1492.…”

Section: Cochin (India) Jews and Spaniards (Of Probably Jewish Originsupporting

confidence: 63%

“…The novel PLS/HMS mutations have been screened in the following populations: healthy unrelated Spaniards from Madrid (n=50), healthy unrelated Moroccans from El Jadida (Morocco) (n=31) (Gómez-Casado et al, 2000), healthy unrelated Jews from Tel-Aviv (Israel) (n=36, 14 Ashkenazi and 22 non-Ashkenazi) (Martínez-Laso et al, 1996), healthy unrelated Algerians from Algiers (Algeria) (n=41) (Arnaiz-Villena et al, 1995).…”

Section: Populationsmentioning

confidence: 99%

“…In this paper, we find the same cathepsin C mutations in Spain (Sepharad for the Jews) from which the Jews were expelled in 1492. Many Jews did not leave Spain in 1492 and forcely "converted" to Christianity (Martínez-Laso et al, 1996). This Spanish PLS family may well be of Jewish origin.…”

Section: Cochin (India) Jews and Spaniards (Of Probably Jewish Originmentioning

confidence: 99%

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Cathepsin C gene: First compound heterozygous patient with Papillon‐Lefèvre syndrome and a novel symptomless mutation

et al. 2001

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Section: Cochin (India) Jews and Spaniards (Of Probably Jewish Originsupporting

confidence: 63%

Section: Populationsmentioning

confidence: 99%

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Cathepsin C gene: First compound heterozygous patient with Papillon‐Lefèvre syndrome and a novel symptomless mutation

et al. 2001

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“…A similar frequency of this allele has been observed in Denmark (Lindblom et al, 1992). In the Jews who emigrated from Central Europe to Israel in the first half of the 20th century (Ashkenazi Jews), the frequency of DRB1*0101 is a quarter of that in our Polish group (Martinez-Laso et al, 1996).…”

Section: Discussionmentioning

confidence: 89%

HLA class II allele and haplotype distribution in a population from central Poland

Krokowski¹,

Bodalski²,

Bratek³

et al. 1998

European Journal of Immunogenetics

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We have studied the distribution of HLA DRB1, DQA1, DQB1 alleles and haplotypes in a sample of 103 unrelated healthy individuals from the region of Lodz in central Poland by the polymerase chain reaction and hybridization with allele-specific oligonucleotide probes (PCR-SSO). DRB1*0101, DRB1*07, DRB1*1501, DRB1*03 and DRB1*11 were the most frequent alleles at the DRB1 locus. The DRB1*04 group was observed at a high frequency, but only five out of the 19 DR4 subtypes tested were observed. The most frequent was DRB1*0401, followed by DRB1*0403, DRB1*0402, DRB1*0407 and DRB1*0417. Eight DQA1 alleles were found in this Polish population, among which DQA1*0501, DQA1*0101 and DQA1*0102 were the most frequent. At the DQB1 locus 13 alleles were found. Among them, four were present with frequencies above 10%: DQB1*0201, DQB1*0301, DQB1*0501 and DQB1*0602. Our results underline significant differences between the population of central Poland and populations of neighbouring countries such as Germany, Ukraine and the Czech Republic. This study will serve as a reference for further anthropological studies, as well as studies of associations between HLA and disease.

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“…Interestingly, previous studies have shown that PV is not associated with HLA-Cw6 in this population, but is associated with the alanine in position 73 (Ala73), which is present in Cw6, Cw7 and some other alleles of HLA-C (Roitberg-Tamburg et al, 1994). The Jewish population have a Caucasoid genetic profile, but differences have been found in allelic and HLA haplotypic frequencies (Gonzá lez-Roces et al, 1994;Roitberg-Tambur et al, 1995;Martínez-Laso et al, 1996;Cox et al, 1999). Thus, the study of this population could help to identify the causative gene of this disease in the HLA region.…”

mentioning

confidence: 93%

The Region of 150 kb Telometic to HLA-C Is Associated with Psoriasis in the Jewish Population

Martínez‐Borra

Brautbar

González

et al. 2005

Journal of Investigative Dermatology

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The HLA-Cw*0602 has been associated with psoriasis in different ethnic groups. But, it remains unclear whether HLA-C is the PSORS1 gene (the psoriasis gene in the MHC). Thus, several case-control studies have been performed in order to investigate whether HLA-C itself determines the susceptibility to the disease. We studied 59 Jewish patients with type I psoriasis and 79 matched controls. Polymorphic genes and markers from HLA-B (centromeric to HLA-C) to the corneodesmosin (CDSN) gene (telomeric to HLA-C) were genotyped in order to determine their contribution to the susceptibility to psoriasis. Neither HLA-Cw*0602 nor the allele CDSN*TTC were significantly associated with psoriasis with the size of the sample studied. The genes and markers telomeric to HLA-C such as the microsatellite C1_4_4 (OR = 2.6, 95% CI = 1.4-4.7, p(c) = 0.018) the octamer transcription factor (OTF)-3 gene (OR = 2.6, 95% CI = 1.6-4.3, p(c) = 0.0001) and the alpha-helix coiled-coil rod homologue (HCR) gene (OR = 2.5, 95% CI = 1.3-4.5, p(c) = 0.004), however, were associated with the disease. These results suggest that a major psoriasis susceptibility gene is likely to be located within a region of 150 kb telomeric to HLA-C and centromeric to the CDSN gene.

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HLA DR and DQ polymorphism in Ashkenazi and non-Ashkenazi Jews: Comparison with other mediterraneans

Cited by 19 publications

References 0 publications

Cathepsin C gene: First compound heterozygous patient with Papillon‐Lefèvre syndrome and a novel symptomless mutation

Cathepsin C gene: First compound heterozygous patient with Papillon‐Lefèvre syndrome and a novel symptomless mutation

HLA class II allele and haplotype distribution in a population from central Poland

The Region of 150 kb Telometic to HLA-C Is Associated with Psoriasis in the Jewish Population

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