HLA DR2 in narcolepsy with sleep-onset REM periods but not cataplexy

Rosenthal, León; Roehrs, Timothy; Hayashi, Hajime; Zorick, Frank; Wittig, Robert M.; Rosenthal, J; Roth, Thomas

doi:10.1016/0006-3223(91)90238-h

Cited by 7 publications

(1 citation statement)

References 15 publications

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“…However, this patient did not have the concomitant periodic leg movement as suggested by the study 27 . On the other hand, there has been a suggestion that this group of hypersomnic patients with SOREMP but without cataplexy should be classified as a clinical variant of narcolepsy in the light of their much stronger association with HLA DR2 than control population 28 . The concept of a narcolepsy spectrum was further strengthened by the observation that this `hypersomnia group with SOREMP' also has a stronger association with HLA DR2 typing than other hypersomnic groups without cataplexy and SOREMP 23 .…”

Section: Discussionmentioning

confidence: 57%

HLA DR2 and DQ1 frequency among narcoleptic patients in Hong Kong Chinese

Wing¹,

Chen²,

Ho³

1998

Psychiatry Clin Neurosci

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Key wordsNarcolepsy is a life-long crippling sleep disorder with significant physical and psychosocial impairments. Although its exact etiology and neuropathology is not clear, a strong association with specific human leucocyte antigen (HLA) subtype, particularly DR2 (DRwI5) and DQwl (DQw6), has been demonstrated across different ethnic groups including Caucasians and Japanese. The presence of 100% association with HLA DR2 in a series of Hong Kong Chinese narcoleptic patients has previously been reported. The report can now be extended, and as far as could be ascertained in the available subjects, all were HLA DQwl (DQw6)-positive. This is concordant with the experiences of Japanese narcoleptic patients who are 100% HLA DR2-and DQwl-positive. However, the definitive account of the population prevalence of narcolepsy in Chinese could be determined only by a well-conducted epidemiological study with laboratory confirmation.Chinese, narcolepsy, 100% association HLA DR2 and DQI.

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Section: Discussionmentioning

confidence: 57%