2016
DOI: 10.29262/ram.v63i3.147
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HLA DRB1*, DQB1*, DPA1*, and DPB1* and their association with the pathogenesis of leukemia in the population of Venezuela

Abstract: Background: The HLA complex is involved in the pathogenesis of leukemia. Objectives: The presence of class II HLA alleles DRB1 *, DQB1 *, DPA1 *, and DPB1 * was evaluated in 47 patients with acute lymphoblastic leukemia (ALL) and 48 with chronic myeloid leukemia (CML) for comparison with 48 healthy volunteers in Zulia, Venezuela, and to evaluate potential associations of HLA with leukemia.

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Cited by 5 publications
(5 citation statements)
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“…Three genes ( SFTPB , WFDC2 , and HLA-DQA1 ) were associated with reduced prognostic risk, while the other six genes ( HLA-DPA1 , TIMP1 , MS4A7 , VCAN , KRT8 , and FABP5 ) were predictors of unfavorable survival. Consistently, in previous studies, a high expression of TIMP1 ( 54 , 55 ), VCAN , KRT8 ( 56 58 ), and FABP5 ( 59 ) and a low expression of SFTPB ( 60 , 61 ), WFDC2 ( 62 , 63 ), and HLA-DQA1 ( 64 , 65 ) were associated with poor prognosis in multiple cancer types. However, a reduced expression of HLA-DPA1 ( 64 , 65 ) and MS4A7 ( 66 ) was reported to be associated with disease progression and unfavorable survival, which differed from the findings in the studies.…”
Section: Discussionsupporting
confidence: 89%
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“…Three genes ( SFTPB , WFDC2 , and HLA-DQA1 ) were associated with reduced prognostic risk, while the other six genes ( HLA-DPA1 , TIMP1 , MS4A7 , VCAN , KRT8 , and FABP5 ) were predictors of unfavorable survival. Consistently, in previous studies, a high expression of TIMP1 ( 54 , 55 ), VCAN , KRT8 ( 56 58 ), and FABP5 ( 59 ) and a low expression of SFTPB ( 60 , 61 ), WFDC2 ( 62 , 63 ), and HLA-DQA1 ( 64 , 65 ) were associated with poor prognosis in multiple cancer types. However, a reduced expression of HLA-DPA1 ( 64 , 65 ) and MS4A7 ( 66 ) was reported to be associated with disease progression and unfavorable survival, which differed from the findings in the studies.…”
Section: Discussionsupporting
confidence: 89%
“…Consistently, in previous studies, a high expression of TIMP1 ( 54 , 55 ), VCAN , KRT8 ( 56 58 ), and FABP5 ( 59 ) and a low expression of SFTPB ( 60 , 61 ), WFDC2 ( 62 , 63 ), and HLA-DQA1 ( 64 , 65 ) were associated with poor prognosis in multiple cancer types. However, a reduced expression of HLA-DPA1 ( 64 , 65 ) and MS4A7 ( 66 ) was reported to be associated with disease progression and unfavorable survival, which differed from the findings in the studies. Especially, both HLA-DPA1 and HLA-DQA1 were reported to be immune genes associated with antigen presentation, whose reduction indicated an immune-suppressive microenvironment and aggressive disease ( 64 , 65 ).…”
Section: Discussionsupporting
confidence: 89%
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“…Furthermore, HLA-DPB1*04:02:01:21 has been recently reported as a novel HLA allele in a patient with acute leukemia in the UK [ 44 ]. In our LSVH cohort, the associations between HLA-DP alleles and cancer risk are consistent with previous associations in non-LS populations across various cancers worldwide [ 44 , 50 , 54 ]. The HLA-DP locus forms part of the highly polymorphic HLA class II molecules, and genetic variations in HLA alleles may lead to variations in the antigen presentation in the specialized antigen-presenting cells, such as dendritic cells, thus potentially influencing or likely protecting against the development of cancer in LSVH [ 55 , 56 ].…”
Section: Discussionsupporting
confidence: 90%
“…Furthermore, HLA-DPB1*04:02:01:21 has been recently reported as a novel HLA allele in a patient with acute leukaemia in the UK [41]. In our LSVH cohort, the associations between HLA-DP alleles and cancer risk are consistent with previous associations in non-LS populations across various cancers, worldwide [41,47,51]. The HLA-DP locus forms part of the highly polymorphic HLA class II molecules, and genetic variations of the HLA alleles may lead to variations in the antigen-presentation on the specialised antigen-presenting cells, such as dendritic cells, thus potentially influencing or likely protecting against the development of cancer in LSVH [52,53].…”
Section: Discussionsupporting
confidence: 90%