HLA‐DRB1: genetic susceptibility and disability progression in a Spanish multiple sclerosis population

Abstract

HLA-DRB1*15 is associated with MS when comparing patients with unrelated healthy controls in a Spanish population. The HLA-DRB1*01 and HLA-DRB1*04 alleles are related to a worse prognosis when considering the time taken to reach severe disability.

Multiple sclerosis genetics

“…In contrast, the HLA-B*44:02 allele, that is proposed to be protective for MS susceptibility, may reduce the radiographic burden of disease on T2-weighted brain MRI (Healy et al, 2010). A consistent impact of HLA alleles on MS neurologic impairments, as measured by expanded disability status scale progression, has not been found (Marrosu et al, 1988;Romero-Pinel et al, 2011). Interestingly, a spontaneously occurring null allele of the HLA-DRB5 gene located telomeric to HLA-DRB1 might contribute to MS severity (Caillier et al, 2008).…”

Epistasis between HLA-DRB1 parental alleles in a Spanish cohort with multiple sclerosis

“…We have shown that several genotypes containing the HLA-DRB1*15 allele are associated with MS susceptibility in our cohort. We demonstrated the association of the disease with the HLA-DRB1*15 allele [20]. The association of MS with DRB1*15 has been well established [3] although it is known that the interaction of this allele with other alleles as well as other loci and even with environmental factors play an important role in increasing or decreasing the MS susceptibility.…”

“…The DRB1*03/15 genotype was also significantly more frequent in patients than in controls although when we considered each allele independently from the other, the DRB1*03 allele did not reach significance after multiple testing correction [20]. The DRB1*03 allele had been found related with MS susceptibility in several cohorts [22][23][24].…”

“…The HLA-DRB1*01 and HLA-DRB1*04 alleles had been previously found independently associated with a worse prognosis also when considering the time taken to reach severe disability [20]. Therefore, an additive epistatic influence may be present in patients with those two parental alleles in conjunction.…”

Associations of HLA DRB1 Alleles with Igg Oligoclonal Bands and Their Influence on Multiple Sclerosis Course and Disability Status

“…Other authors claim that OCBs can determine better disability status [14]. Koch et al found that there was no relation between OCBs and disability, as well as RR MS form tendency to change to SP form [18], in addition, L. Romero-Pinel et al suggest that HLA DRB1 alleles have no impact on MS course change [24].…”