HLA-G 14-bp Insertion/Deletion Polymorphism in Kidney Transplant Patients With Metabolic Complications

14–Base pair polymorphism of human leukocyte antigen–G as genetic determinant in heart transplantation and cyclosporine therapy monitoring

“…Preliminary data showed that HLA-G 14-bp genotypes, although not predictive of rejection, may be useful to identify individuals at risk for the development of post-transplantation complications [29].…”

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“…Included characteristics were the name of the first author, year of publication, country of study origin, source of control group, sample size, and HardyWeinberg equilibrium (Table 1). [4][5][6][7][8][9] Statistical analyses All statistical analyses were performed with software (Stata 11.0, StataCorp, College Station, TX, USA) using 2-sided tests. The chi-square test was used to compare genotype (likelihood ratio P value) and allele frequencies (continuity correction P value) between the kidney recipient and healthy control groups.…”

“…Therefore, 5 studies that included a total of 907 kidney transplant recipients (rejection, 271 patients; no rejection, 636 patients) and 887 healthy control subjects were included in the meta-analysis (Table 1). [5][6][7][8][9] According to the Newcastle-Ottawa quality assessment scale, all the studies were of high quality ( Table 2).…”

Human leukocyte antigen–G 3′ untranslated region polymorphisms are associated with better kidney allograft acceptance

“…HLA-G induces CD3 ϩ CD4 low and CD3 ϩ CD8 low cell phenotypes that suppress T-cell subsets involved in transplant acceptance [16]. In addition, polymorphic sites in the HLA-G gene associated with increased production of HLA-G have been associated with better kidney allograft outcomes [17,18].…”

“…Regarding HLA-G 3=UTR polymorphic sites and kidney transplantation outcome, only the 14-bp Ins/Del polymorphism has been evaluated so far, and the insertion was associated with susceptibility to acute rejection [17] and to metabolic complications [18]. To address the question of whether other HLA-G 3=UTR polymorphic sites are implicated in transplant tolerance, we evaluated a portion of this region that includes almost all polymorphic sites already identified in patients undergoing kidney transplantation, exhibiting or not exhibiting episodes of graft rejection.…”