HLA-G Expression and Regulation During
            <i>Pseudomonas Aeruginosa</i>
            Infection in Cystic Fibrosis Patients

Rizzo, Roberta; Bergamini, Gabriella; Bortolotti, Daria; Leal, Teresinha; D'Orazio, Ciro; Pintani, Emily; Melchiorri, Loredana; Zavatti, Eleonora; Assael, B.M.; Sorio, Claudio; Melotti, Paola

doi:10.2217/fmb.15.143

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…However, in the airway system, higher expression of HLA-G is associated with P. aeruginosa infection. Moreover, CF cell line and murine model expressed higher HLA-G molecules in the presence of P. aeruginosa , thus suggesting a role of HLA-G in reducing systemic inflammation, thus supporting P. aeruginosa infection [ 74 ].…”

Section: Hla-g In Infectious Diseasesmentioning

confidence: 99%

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Morandi

Rizzo

Fainardi

et al. 2016

Journal of Immunology Research

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110

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HLA-G is a HLA-class Ib molecule with potent immunomodulatory activities, which is expressed in physiological conditions, where modulation of the immune response is required to avoid allograft recognition (i.e., maternal-fetal interface or transplanted patients). However, HLA-G can be expressed de novo at high levels in several pathological conditions, including solid and hematological tumors and during microbial or viral infections, leading to the impairment of the immune response against tumor cells or pathogens, respectively. On the other hand, the loss of HLA-G mediated control of the immune responses may lead to the onset of autoimmune/inflammatory diseases, caused by an uncontrolled activation of the immune effector cells. Here, we have reviewed novel findings on HLA-G functions in different physiological and pathological settings, which have been published in the last two years. These studies further confirmed the important role of this molecule in the modulation of the immune system.

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Section: Hla-g In Infectious Diseasesmentioning

confidence: 99%

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Morandi

Rizzo

Fainardi

et al. 2016

Journal of Immunology Research

Self Cite

110

View full text Add to dashboard Cite

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“…Since its discovery, many studies described the role of sHLA-G expression in tumor cells and cancers [24][25][26][27], recurrent pregnancy loss [28], regulating host immune responses, and recently have begun to be reported in other pathological conditions, including infectious diseases [13,14]. In particular, HLA-G upregulation has been reported in studies of bacterial infections [29][30][31][32][33]; however, there is no study about the role of salivary sHLA-G in dental caries. is study is the first attempt to evaluate the concentration of salivary sHLA-G and its relationship with dental caries in children.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries

Bijani

Mostafazadeh

Mina

et al. 2020

International Journal of Dentistry

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Aim and Background. Early childhood caries (ECC) is a common type of dental caries affecting children. As dental caries is a bacterial infectious disease, the host immune system parameters including soluble human leukocyte antigen-G (sHLA-G) are essential factors in estimating dental caries. The study aimed to investigate and compare the concentration of sHLA-G in the saliva of children with or without dental caries. Methods and Materials. This analytic cross-sectional study was carried out on 83 healthy children aged 3 to 5 years of both genders, who were divided into three groups based on decayed dental surfaces (ds): group 1, caries-free children (CF, n = 29); group 2, children with 1 ≤ ds ≤ 3, 1 ≤ ds ≤ 4, and 1 ≤ ds ≤ 5 for age 3, 4, and 5 years, respectively (ECC, n = 20); and group 3, children with ds ≥ 4, ds ≥ 5, and ds ≥ 6 for age 3, 4, and 5 years, respectively (S-ECC, n = 34). The unstimulated saliva samples were collected, and the salivary sHLA-G concentration was measured by the ELISA kit. The SPSS Statistics v17.0 software and Mann–Whitney, Kruskal–Wallis, chi-square, and Spearman’s rank correlation tests were used for statistical analysis. The level of significance was considered at p<0.05. Results. The mean concentrations of salivary sHLA-G in CF, ECC, and S-ECC groups were 3.18 ± 2.28, 5.64 ± 5.51, and 6.21 ± 6.03 ng/l, respectively (p=0.047), and the mean salivary sHLA-G level was comparatively higher in children with dental caries than that of the CF group (p=0.02), but there is no significant difference between ECC and S-ECC groups (p>0.05). Spearman’s rank correlation test showed a weak positive correlation (p=0.039, r = 0.22), between the level of salivary sHLA-G and dental caries. Conclusion. The present study provides some preliminary evidences on relationship between sHLA-G and dental caries in children.

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Soluble HLA-G pre-transplant levels to identify the risk for development of infection in heart transplant recipients

et al. 2020

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HLA-G Expression and Regulation During Pseudomonas Aeruginosa Infection in Cystic Fibrosis Patients

Abstract: Plasmatic and lung HLA-G expression suggest a role in reducing systemic inflammation and supporting P. aeruginosa infection.

Cited by 8 publications

References 33 publications

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases

Evaluation of the Level of Salivary sHLA-G in Children Aged 3–5 Years with or without Dental Caries

Soluble HLA-G pre-transplant levels to identify the risk for development of infection in heart transplant recipients

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