HLA haplotypes in recurrent aphthous stomatitis: a mode­ of inheritance?

Abstract

The aim of this study was to investigate the genetic association between recurrent aphthous stomatitis (RAS) and human leucocyte antigen (HLA) class I and II alleles and HLA haplotypes. Families selected had at least one child suffering from recurrent aphthous stomatitis in addition to one or both of the parents. HLA-A, -B and -DR alleles were typed in 29 families, 27 nuclear and two extended (121 subjects). HLA haplotypes of all family members with RAS were compared with those who were RAS negative. Although major histocompatibility complex class I and II gene analysis failed to demonstrate any significant association between RAS and HLA antigens, the study of HLA haplotypes revealed a significant association between HLA haplotypes and susceptibility to RAS. The results indicate that susceptibility to RAS segregates in families in association with HLA haplotypes.

Etiopathogenesis of Recurrent Aphthous Stomatitis and the Role of Immunologic Aspects: Literature Review

“…The role of DNA polymorphisms in serotonin transporter gene, endothelial nitric oxide synthase gene and cell adhesion molecule genes has also been considered (Alkhateeb et al 2013; Gallo et al 2012; Karasneh et al 2005, 2009; Kim et al 2003; Oksel et al 2006; Salvarani et al 2002; Victoria et al 2005; Wang and Wang 2000). Other researchers reported the correlation between the selected HLA allele and the increased risk of RAS and Behçet’s syndrome (Albanidou-Farmaki et al 2008; Challacombe et al 1977; Sun et al 2001). In patients with RAS, a higher incidence of HLA-A33, HLA-B35 and HLA-B81 (Wilhelmsen et al 2009), HLA-B12 (Lehner et al 1982), HLA-B51 (Özdemir et al 2009), HLA-DR7 and HLA-DR5 and lower incidence of HLA-B5 and HLA-DR4 (Albanidou-Farmaki et al 1988; Gallina et al 1985) was observed when compared to healthy controls.…”

Recurrent Aphthous Stomatitis

“…Certain genetically specific HLAs have been identified in RAS patients: HLA-A2, HLA-B5, HLA-B12, HLA-B44, HLA-B51, HLA-B52, HLA-DR2, HLA-DR7, and HLA-DQ series 47 . A confounding finding is that certain ethnic groups have been associated with different HLA alleles or haplotypes with no HLA consistently associated with RAS 47 .…”

Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis

“…The study included 32 RAS cases who applied to outpatient clinic of oral medicine department of Tehran University of Medical Sciences and 32 healthy individuals who age and sex were matched. The RAS patients had oral ulcer attack recurring at least three times a year and had active lesions during the study (1,10). RAS was diagnosed clinically by an expert in oral medicine.…”