HLA may be involved in resistance and susceptibility to affective disorders

Payami, Haydeh; Dubay, Christopher; Valenzuela, R. Carrero

doi:10.1002/gepi.1370060151

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…alcoholism, or in other situations known to lower magnesium levels [28][29][30], We must take into account that blood magnesium levels and magnesium metabolism might depend on many factors, including sasonal chronorhythms, ethnic origin, food intake, and genetic deter mination such as human lymphocyte antigens (HLA) [31,32], Indeed, some evidence that HLA groups might be involved in susceptibility to affective disorders has been reported [33].…”

Section: Discussionmentioning

confidence: 99%

Evolution of Blood Magnesium, Sodium and Potassium in Depressed Patients Followed for Three Months

Widmer¹,

Bovier²,

Karege³

et al. 1992

Neuropsychobiology

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No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerned treated patients. We confirmed in this study that drug-free depressed patients have higher erythrocyte and plasma magnesium than controls, as shown in previous reports. Significant differences are observed in patients for sex and between clinical subgroups. Low plasma potassium levels are described in both male and female depressed patients. The erythrocyte magnesium level tends to normalize in parallel with clinical improvement, depending on sex and clinical subgroup, and seems then to be related to the intensity of the depression. Plasma magnesium in male and female patients, except for female unipolars, remains higher than controls in all conditions and might be related to the diagnosis of affective disorders.

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Section: Discussionmentioning

confidence: 99%

Evolution of Blood Magnesium, Sodium and Potassium in Depressed Patients Followed for Three Months

Widmer¹,

Bovier²,

Karege³

et al. 1992

Neuropsychobiology

View full text Add to dashboard Cite

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Genetic analysis of the affective disorders: Summary of GAW5

Rice

Risch

1989

Genetic Epidemiology

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Participants in the Affective Disorders component of Genetic Analysis Workshop 5 had access to five distributed data sets: 1) 187 families from the Collaborative Depression Study, 2) 202 families ascertained as part of the NIMH Family Studies on Affective Disorders, 3) a compilation of 46 pedigrees informative for X-linked markers, 4) HLA typing on 116 kindreds from the Toronto-Rochester Depression Study, and 5) 81 members of an Old Order Amish pedigree demonstrating linkage to markers on chromosome 11p. These databases are each summarized after a brief account is given of the genetics of the affective disorders and commonly used diagnoses. The emphasis of the Workshop was methodologic, with contributions divided evenly between linkage and nonlinkage applications. Contributions are summarized under four substantive areas: regressive logistic models, segregation and other familial analyses, methodologic considerations in linkage analysis, and the relationship between HLA and affective disorders.

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