HLA polymorphism and early rheumatoid arthritis in the Moroccan population

Atouf, O.; Benbouazza, Karima; Brick, C.; Bzami, Fatiha; Bennani, N.; Amine, Bouchra; Hajja-Hassouni, Najia; Essakali, Malika

doi:10.1016/j.jbspin.2008.01.027

Cited by 32 publications

(28 citation statements)

References 32 publications

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“…In line with our study, RA patients in Greece were also observed to have the DRB1*10 alleles (14). However, no significant relationship between the DRB1*10 alleles and RA was observed in studies conducted in Morocco (18), Kuwait (19) and Pakistan (13). In our study, the DRB1*10 and DRB1*1001 were found to be statistically significantly associated with the predisposition to RA.…”

Section: Discussionsupporting

confidence: 88%

“…Moreover, the DRB1*04 and the erosive and non-erosive forms of the disease were also found to be unrelated with each other (19). Contrarily, in a study in Morocco, the frequency of RF was observed to be higher in patients carrying the DRB1*04 and it was concluded that the HLA alleles may play an important role in patients with early seropositive RA (18).…”

Section: Discussionmentioning

confidence: 93%

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Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Batmaz¹,

Sarıyıldız²,

Dilek³

et al. 2013

Tftr

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 93%

Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Batmaz¹,

Sarıyıldız²,

Dilek³

et al. 2013

Tftr

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“…The most striking finding of the present study was the appearance of higher frequencies of HLA-DQBI*06 allele in RA patients as compared to the data which was collected from available studies that were related directly to RA [6,7]. Moreover, HLA-DQBI*06 allele was much more frequently seen in our RA patients with severe and high disease activity, as well as in RF and Anti-CCP positive patients as compared to other genotypes.…”

Section: Discussionsupporting

confidence: 58%

“…The most frequent alleles which were identified in the RA patients were HLA-DRBI*01 and HLA-DQBI*06, whereas in healthy subjects they were HLA-DRBI*11 and HLA- -4]: Distribution of the most frequent HLA-DR/DQ genotypes by disease activity score (DAS-28) in RA patients F: frequency of alleles; *Active RA odds ratios versus moderate RA www.jcdr.net Dhia J. Al-Timimi et al, HLA-DR/DQ Genotypes in Kurd Patients with Rheumatoid Arthritis: Relation to Disease Activity associated more strongly with a high disease activity subset. In a study done by Arouf et al, [6], it was reported that the presence of RF was more frequent in patients who carried the HLA-DRBI* 04 allele. However, in our study, the most frequent allele of HLAgenotypes which was identified in RA patients was HLA-DQBI*6 (34.6%), whereas in healthy controls, it was HLA-DRBI*03 (35.4%).…”

Section: Resultsmentioning

confidence: 94%

HLA-DR/DQ Genotypes in Kurd Patients with Rheumatoid Arthritis: Relation to Disease Activity

Al-Timimi

Rasool

Sulaiman

2014

JCDR

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“…Mais en raison de l'efficacité remarquable des biothérapies dans cette maladie chronique sévèrement handicapante, il est indispensable de développer une stratégie nationale tenant compte du statut socio-économique et du profil local de la maladie [5]. Parallèlement, cette étude a confirmé l'association PR et HLA-DRB1*04 chez les PR avec facteur rhumatoïde positif [19]. Comme dans d'autres pays arabes, aucune liaison n'a été mise en évidence entre la maladie et les allèles HLA-DRB1*01, DRB1*10 and DRB1*14.…”

Section: La Cohorte De Polyarthrites Récentes El Ayachiunclassified

Rheumatoid Arthritis in Morocco: Past and Present

Hajjaj–Hassouni

2017

IJMS

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RESUMELa polyarthrite rhumatoïde (PR) est le chef de file des rhumatismes inflammatoires chroniques (RIC). Elle touche environ 1% de la population mondiale. C'est une affection invalidante qui conduit plus ou moins rapidement à la destruction cartilagineuse et osseuse et, à long terme, en l'absence de traitement, à l'incapacité fonctionnelle et/ou au handicap sévères. L'importance de son diagnostic et de son traitement précoces est majeure. Au Maroc, le retentissement socio-économique de la maladie est important. Les difficultés à l'accès au traitement des patients, les conséquences sur leur vie personnelle et familiale ont été mises en évidence. Parmi elles, les conséquences négatives sur la scolarisation des petites filles sont significatives. De ce fait, la prévention et l'information sont majeures dans la prise en charge des patients de même que le recours à un traitement à « un coût raisonnable ». Par ailleurs, la comparaison des données, grâce à l'inclusion dans des études internationales mettent en évidence la sévérité de la maladie, essentiellement en raison du retard au diagnostic, du retard à la prise en charge en rhumatologie, du bas niveau socio-économique. La mise en place d'une cohorte de polyarthrites récentes suivies sur une période de deux ans, a mis en évidence l'importance d'un diagnostic et d'une prise en charge très précoces et l'amélioration significative du pronostic de la maladie qui en résulte. Elle a été suivie par la mise en place d'une cohorte de polyarthrites récentes dont l'objectif est un suivi de polyarthrites récentes évoluant depuis moins d'un an sur une période de dix ans et la constitution d'une base de données destinée à permettre des études sur le diagnostic, le pronostic, l'épidémiologie, l'impact socio-économique ainsi que le recours à un traitement économiquement accessible des polyarthrites récentes au Maroc. MOTS CLÉS : Polyarthrite Rhumatoïde, Polyarthrite Récente, Polyarthrite Indifférenciée, Cohorte, Maroc. ABSTRACTIn Morocco, the socio-economic impact of the disease is significant. The difficulties of the patients in accessing treatment, the consequences on their personal and familial life have been highlighted. Among them, the negative consequences on the schooling of female children are significant. Because of this, prevention and information are of high importance in the management of patients as well as the use of treatment at a « reasonable cost ». Moreover, the comparison of the data, thanks to inclusion in international studies, has allowed the demonstration of the severity of the disease, mainly due to delayed diagnosis, delay in referral to rheumatologists and low socioeconomic status. The setting up of a cohort of recent polyarthritis followed over a two-year period has highlighted the importance of very early diagnosis and management and the resulting significant improvement in the prognosis of the disease. It has been followed by the setting up of a cohort of recent polyarthritis the objective of which is a follow-up of recent polyarthritis progressing l...

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HLA polymorphism and early rheumatoid arthritis in the Moroccan population

Cited by 32 publications

References 32 publications

Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

HLA-DR/DQ Genotypes in Kurd Patients with Rheumatoid Arthritis: Relation to Disease Activity

Rheumatoid Arthritis in Morocco: Past and Present

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