HLA Polymorphism in Algerian Children With Lymphomas

Galleze, Assia; Raache, Rachida; Amroun, Habiba; Cherif, N.; Ibrahim, Mohamed; Meçabih, Fethi; Mecheti, B.; Belhani, M; Bensenouci, A.; Abbadi, Mohamed Chérif; Attal, Nabila

doi:10.1097/mph.0000000000000419

Cited by 5 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies on lymphoma include: (1) the role of TP73 and FOXP3 in the pathogenesis of reactive lymphoid hyperplasia and diffuse B-cell lymphoma, as well as the contribution of HLA-G polymorphism to non-Hodgkin lymphoma in Egypt ( 398 – 400 ), (2) susceptibility of individuals with A/A genotype of TNF promoter (-308A/G) to non-Hodgkins lymphoma in Tunisia ( 401 ) and Egypt ( 402 ) and the identification of HLA-B*18 , DRB1*03 , DRB1*07 , and DQB1*02 as lymphoma susceptibility loci in Algerian children ( 403 ).…”

Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

View full text Add to dashboard Cite

Cancer is the second leading cause of death globally and is projected to overtake infectious disease as the leading cause of mortality in Africa within the next two decades. Cancer is a group of genomic diseases that presents with intra- and inter-population unique phenotypes, with Black populations having the burden of morbidity and mortality for most types. At large, the prevention and treatment of cancers have been propelled by the understanding of the genetic make-up of the disease of mostly non-African populations. By the same token, there is a wide knowledge gap in understanding the underlying genetic causes of, and genomic alterations associated with, cancer among black Africans. Accordingly, we performed a review of the literature to survey existing studies on cancer genetics/genomics and curated findings pertaining to publications across multiple cancer types conducted on African populations. We used PubMed MeSH terms to retrieve the relevant publications from 1990 to December 2019. The metadata of these publications were extracted using R text mining packages: RISmed and Pubmed.mineR. The data showed that only 0.329% of cancer publications globally were on Africa, and only 0.016% were on cancer genetics/genomics from Africa. Although the most prevalent cancers in Africa are cancers of the breast, cervix, uterus, and prostate, publications representing breast, colorectal, liver, and blood cancers were the most frequent in our review. The most frequently reported cancer genes were BRCA1, BRCA2, and TP53. Next, the genes reported in the reviewed publications’ abstracts were extracted and annotated into three gene ontology classes. Genes in the cellular component class were mostly associated with cell part and organelle part, while those in biological process and molecular function classes were mainly associated with cell process, biological regulation, and binding, and catalytic activity, respectively. Overall, this review highlights the paucity of research on cancer genomics on African populations, identified gaps, and discussed the need for concerted efforts to encourage more research on cancer genomics in Africa.

show abstract

Section: Resultsmentioning

confidence: 99%

A Review of Cancer Genetics and Genomics Studies in Africa

Rotimi

Salhia

2021

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…Both CTL and CD4+ T‐cells that recognize HLA class I and class II, respectively, are involved in an antitumor immune response against EBV 62 . Of note, HLA class I region polymorphism is known to have consistent susceptibility effects on sporadic and familial EBV‐positive childhood and adult HL across different geographical locations 63‐69 . The classic case study of familial HL demonstrated that clustering of EBV and certain identical HLA genotypes in pediatric patients with HL can occur in a single‐family 66 in which three siblings were diagnosed with EBV‐positive HL had different HLA class I phenotype from their two unaffected siblings.…”

Section: Tme Modulatorsmentioning

confidence: 99%

“… 62 Of note, HLA class I region polymorphism is known to have consistent susceptibility effects on sporadic and familial EBV‐positive childhood and adult HL across different geographical locations. 63 , 64 , 65 , 66 , 67 , 68 , 69 The classic case study of familial HL demonstrated that clustering of EBV and certain identical HLA genotypes in pediatric patients with HL can occur in a single‐family 66 in which three siblings were diagnosed with EBV‐positive HL had different HLA class I phenotype from their two unaffected siblings. These studies suggest that the antigenic presentation of EBV‐derived peptides is involved in the development of HL (Figure 2 ).…”

Section: Tme Modulatorsmentioning

confidence: 99%

The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes

2020

View full text Add to dashboard Cite

Background: Classical Hodgkin lymphoma (cHL) is a unique lymphoid malignancy with a tumor microenvironment (TME) consisting of a small number of neoplastic—Hodgkin and Reed‐Sternberg (H‐RS) cells (<1%), surrounded by a large number of nonneoplastic infiltrating immune cells (>90%). The TME of cHL critically depends on immune cells to support tumor growth as H‐RS cells cannot survive and proliferate in isolation. Recent Findings: Programmed cell death protein 1 (PD‐1) ligand expressed on H‐RS cells inhibits the clearance of tumor by causing T‐cell exhaustion. Nivolumab and pembrolizumab, PD‐1 inhibitors, have been proven to be effective in treating adult and pediatric patients with R/R cHL. Tumor‐associated macrophages (TAMs) are a central component of TME and are known to cause poor prognosis in adult HL. However, the prognostic impact of CD68+ TAMs in pediatric HL remains ambiguous. EBV modulates the tumor milieu of HL and plays a strategic role in immune escape by enrichment of the TME with Treg cells and associated immunosuppressive cytokines in adult HL. In contrast, EBV+ pediatric patients have increased infiltration of CD8+ T‐cells and show a better therapeutic response suggesting viral‐related TME is distinct in childhood HL. The role of CASP3 in apoptosis of H‐RS cells and its correlation with response prediction in adult and pediatric HL suggest it may serve as a potential biomarker. In cHL, CD30, EBV, and NF‐κB signaling employ exosomes for cell–cell communication that triggers the migration capacity of fibroblasts, stimulate to produce proinflammatory cytokines, and help to create a tumor‐supportive microenvironment. Conclusion: The cHL microenvironment is distinct in adult and pediatric HL. Future studies are required to understand the role of interplay between H‐RS cells and EBV‐associated microenvironment and their clinical outcome. They may present novel therapeutic targets for the development of antilymphoma therapy.

show abstract

“…In the case of mycosis fungoides and Sezary syndrome, this protective association was mentioned by Jackow et al [ 27 ], who identified HLA-DR6 (*1301, *1302, and *1402) but unfortunately, the association did not remain valid after the correction of p . Another study conducted by Galleze et al [ 64 ] mentioned HLA-DRB1*13 and HLA-DQB1*03 for their protective effect against Hodgkin lymphoma and non-Hodgkin lymphoma.…”

Section: Discussionmentioning

confidence: 99%

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

Tizu,

Calenic,

Maruntelu

et al. 2024

Medical Sciences

View full text Add to dashboard Cite

Background and Objectives: The implications of the genetic component in the initiation and development of chronic lymphoproliferative disorders have been the subject of intense research efforts. Some of the most important genes involved in the occurrence and evolution of these pathologies are the HLA genes. The aim of this study is to analyze, for the first time, possible associations between chronic lymphoproliferative diseases and certain HLA alleles in the Romanian population. Materials and Methods: This study included 38 patients with chronic lymphoproliferative disorders, diagnosed between 2021 and 2022 at Fundeni Clinical Institute, Bucharest, Romania, and 50 healthy controls. HLA class I and class II genes (HLA-A/B/C, HLA-DQB1/DPB1/DRB1) were investigated by doing high resolution genotyping using sequence specific primers (SSP). Results: Several HLA alleles were strongly associated with chronic lymphoproliferative disorders. The most important finding was that the HLA-C*02:02 (p = 0.002, OR = 1.101), and HLA-C*12:02 (p = 0.002, OR = 1.101) have a predisposing role in the development of chronic lymphoproliferative disorders. Moreover, we identified that HLA-A*11:01 (p = 0.01, OR = 0.16), HLA-B*35:02 (p = 0.037, OR = 0.94), HLA-B*81:01 (p = 0.037, OR = 0.94), HLA-C*07:02 (p = 0.036, OR = 0.34), HLA-DRB1*11:01 (p = 0.021, OR = 0.19), and HLA-DRB1*13:02 (p = 0.037, OR = 0.94), alleles have protective roles. Conclusions: Our study indicates that HLA-C*02:02 and HLA-C*12:02 are positively associated with chronic lymphoproliferative disorders for our Romanian patients while HLA-DRB1*11:01, HLA-DRB1*13:02, and HLA-B*35:02 alleles have a protective role against these diseases.

show abstract

HLA Polymorphism in Algerian Children With Lymphomas

Abstract: These results indicate that HLA-B18, DRB103, 07, and DQB102 may contribute to lymphoma susceptibility, whereas HLA-DRB113 and DQB103 may confer protection to lymphoma in the Algerian population.

Cited by 5 publications

References 22 publications

A Review of Cancer Genetics and Genomics Studies in Africa

A Review of Cancer Genetics and Genomics Studies in Africa

The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

Contact Info

Product

Resources

About

HLA Polymorphism in Algerian Children With Lymphomas

Abstract: These results indicate that HLA-B*18, DRB1*03, *07, and DQB1*02 may contribute to lymphoma susceptibility, whereas HLA-DRB1*13 and DQB1*03 may confer protection to lymphoma in the Algerian population.

Cited by 5 publications

References 22 publications

A Review of Cancer Genetics and Genomics Studies in Africa

A Review of Cancer Genetics and Genomics Studies in Africa

The circuitry of the tumor microenvironment in adult and pediatric Hodgkin lymphoma: cellular composition, cytokine profile, EBV, and exosomes

Immunogenetic Background of Chronic Lymphoproliferative Disorders in Romanian Patients—Case Control Study

Contact Info

Product

Resources

About

Abstract: These results indicate that HLA-B18, DRB103, 07, and DQB102 may contribute to lymphoma susceptibility, whereas HLA-DRB113 and DQB103 may confer protection to lymphoma in the Algerian population.