HLA Polymorphisms and Haplotype Diversity in Transylvania, Romania

Vică, Mihaela Laura; Matei, Horea; Bondor, Cosmina Ioana; Nicula, Gheorghe Zsolt; Siserman, Costel Vasile; Loga, Luminița; Dican, Lucia

doi:10.1155/2019/1342762

Cited by 7 publications

(7 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most prevalent haplotype identified in both the severe and control groups was A*01~B*08~C*07~DRB1*03~DQB1*02 (Table 9). This haplotype aligns with the most frequently found haplotype in our previous study conducted on the population of Romanian origin in Transylvania [37]. To differentiate between the two groups more accurately, further studies employing high-resolution tests would be necessary.…”

Section: Discussionsupporting

confidence: 83%

“…Therefore, the study was conducted on a cohort of 130 individuals of Romanian origin, the population for whom HLA association studies with COVID-19 had not been conducted before. Furthermore, there are few studies regarding the frequency of HLA alleles and haplotypes in the population of this region [36,37], and our previous studies have attempted to determine correlations between HLA alleles and certain infectious diseases or mental conditions in this population [10,[38][39][40].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

Vică,

Dobreanu,

Curocichin

et al. 2024

IJMS

View full text Add to dashboard Cite

In this study, we aimed to investigate whether specific HLA alleles found in patients from Romania and the Republic of Moldova were associated with the severity of COVID-19 infection and its associated mortality. We analyzed the HLA alleles at the -A, -B, -C, -DRB1, and -DQB1 loci in a cohort of 130 individuals with severe and extremely severe forms of COVID-19, including 44 individuals who died. We compared these findings to a control group consisting of individuals who had either not been diagnosed with COVID-19 or had experienced mild forms of the disease. Using multivariate logistic regression models, we discovered that the B*27 and B*50 alleles were associated with an increased susceptibility to developing a severe form of COVID-19. The A*33 and C*15 alleles showed potential for offering protection against the disease. Furthermore, we identified two protective alleles (A*03 and DQB1*02) against the development of extremely severe forms of COVID-19. By utilizing score statistics, we established a statistically significant association between haplotypes and disease severity (p = 0.021). In summary, this study provides evidence that HLA genotype plays a role in influencing the clinical outcome of COVID-19 infection.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

Vică,

Dobreanu,

Curocichin

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Research on the correlation of HLA profiles with autoimmune thyroid pathology is in an incipient phase, and extremely different and often contradictory results are being reported in studies conducted worldwide. Such discrepancies may be attributed to differences in allelic distribution among various populations [46], the generally small samples studied to date, and to the different methods employed in the research.…”

Section: Discussionmentioning

confidence: 99%

“…The different frequency of HLA alleles in various populations helps in both investigating the function of HLA genes and the genetic differentiation between individuals [42][43][44]. Some studies conducted in the population of Transylvania, Romania, revealed the frequency of HLA profiles and their association with some pathological conditions [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

HLA Class II Allele Groups Involved in Autoimmune Thyroid Diseases: Hashimoto’s Thyroiditis and Basedow–Graves Disease

Chiorean,

Nicula,

Bâlici

et al. 2024

Life

View full text Add to dashboard Cite

Autoimmune thyroid diseases (AITD), particularly Hashimoto’s thyroiditis (HT) and Basedow–Graves disease (BGD) are diseases of global public health concern, characterized by autoimmune attacks on the thyroid gland, leading to hypothyroidism in HT and hyperthyroidism in BGD. We conducted a study between 2019 and 2021 in northwestern Transylvania (Romania) on patients with HT and with BGD compared to the control group. The aim of the study was to investigate the correlations of HLA class II alleles with AITD by identifying potential genetic susceptibility factors such as HLA-DRB1 and HLA-DQB1 genes in patients diagnosed with HT and BGD. Various molecular biology methods, including SSP-PCR low-resolution and PCR-SSO were employed to analyze DNA samples from patients and control subjects. Our study revealed the influence of the HLA-DRB1*03/*16 genotype as a genetic susceptibility factor for HT, a similar influence regarding BGD being observed for the HLA-DRB1*03 allele group, DRB1*03/*16 genotype, and the DRB1*03/DQB1*06 haplotype. The only protective factor detected in our study was the HLA-DRB1*13 allele group, for both HT and BGD. By elucidating any specific allele or genotype associations that might contribute to the development of AITD, our study can contribute to the prevention and early detection of these diseases.

show abstract

“…Regarding the Transylvanian population, a study on 2,719 controls [37] analyzing the relative frequencies of HLA-DRB1 alleles found DRB1*11 (19%, n = 1033) to be the most frequent HLA-DRB1 allele, as was in Hungary, Greece, Serbia, Croatia, Slovakia, and Italy. Second most frequent were DRB1*03 and DRB1*13 (both 11.4%, n = 620), followed by DRB1*07 (10.6%, n = 576) and DRB1*16 The main limitation of our study consisted in the analysis of a Caucasian population of little ethnic variability from six Transylvanian counties and was also negatively impacted by the absence of a comprehensive HLA allele frequency database regarding Romanian patients with suicidal behavior, covering various ethnic subgroups from all regions of the country.…”

Section: Discussionmentioning

confidence: 99%

Association of HLA class II alleles with suicidal behavior in a Transylvanian population

Vuscan

Vică

Bâlici

et al. 2023

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

Background: Suicide is a complex phenomenon determined by the interaction of various risk factors. The Major Histocompatibility Complex is the most polymorphic gene cluster of the entire human genome, being linked to both the regulation of the immune system and various psychiatric diseases. The aim of this study was to identify HLA-DQB1 and DRB1 alleles and genotypes susceptible to influence suicidal behavior. Methods: We explored the association of HLA-DQB1 alleles with the suicidal behavior on a sample of 427 individuals (including 110 suicide attempters) from Transylvania, as well as the association of HLA-DRB1 alleles with the suicidal behavior on a sample of 271 individuals (including 50 suicide attempters), using the single specific primer-PCR (SSP-PCR) technique. Results: We found that the HLA-DQB1*02, *03 and *06 alleles, the DQB1*02/*03, DQB1*02/*06, DRB1*12/*15 and DRB1*07/*13 genotypes, as well as the DQB1*06~DRB1*07 and DQB1*02~DRB1*13 haplotypes, were more frequent in suicide attempters. In contrast, the HLA-DQB1*04 and DQB1*13 alleles, the DQB1*02/*05 and DQB1*03/*05 genotypes and the DQB1*03~DRB1*13 haplotype were less frequent in the case group. Conclusion: HLA-DQB1*02, *03 and *06 alleles and the DQB1*02/*03 and *02/*06 genotypes are susceptible to favor a suicide behavior, while the HLA-DQB1*04 and *13 alleles and the DQB1*02/*05 and *03/*05 genotypes were protective against such behavior. A similar analysis regarding the HLA-DRB1 alleles detected a possible risk for suicidal behavior among individuals possessing either the DRB1*12/*15 or the DRB1*07/*13 genotypes. DQB1*06~DRB1*07 and DQB1*02~DRB1*13 haplotypes were found susceptible to favor a suicidal behavior, while DQB1*03~DRB1*13 exhibited a protective influence.

show abstract

HLA Polymorphisms and Haplotype Diversity in Transylvania, Romania

Cited by 7 publications

References 20 publications

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

The Influence of HLA Polymorphisms on the Severity of COVID-19 in the Romanian Population

HLA Class II Allele Groups Involved in Autoimmune Thyroid Diseases: Hashimoto’s Thyroiditis and Basedow–Graves Disease

Association of HLA class II alleles with suicidal behavior in a Transylvanian population

Contact Info

Product

Resources

About