HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway

Wu, Longyan; Zhang, Cai; Zhang, Jian

doi:10.1038/cmi.2011.20

Cited by 33 publications

(29 citation statements)

References 32 publications

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“…31 NK cell development and function is controlled by a series of elements, including T-bet, E4BP4, IRF2, HMBOX1 and GATA3. [32][33][34][35] NKPs and immature NK cells can also be found in peripheral organs, suggesting that at any stage, NK cells can leave the BM and finish their development at peripheral sites. 34,36 Maturation of NK cells is accompanied by the expression of a series of activating and inhibitory receptors.…”

Section: Prerequisites For Nk Cell Memorymentioning

confidence: 99%

Memory NK cells: why do they reside in the liver?

et al. 2013

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Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer (NK) cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of NK cell memory by summarizing recent progress and discuss how the liver may generate both the initiation and the recall phase of memory. We propose that the liver may have unique precursors for memory NK cells, which are developmentally distinct from NK cells derived from bone marrow.

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Section: Prerequisites For Nk Cell Memorymentioning

confidence: 99%

Memory NK cells: why do they reside in the liver?

et al. 2013

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“…26 IFNs or DC/macrophage-derived cytokines, such as type I IFN, IL-12, IL-18 and IL-15, enhance the activation or promote the maturation of NK cells, which can also augment NK cell cytolytic activity against tumor cells. [30][31][32] Cytotoxic activity of NK cells can increase approximately 20-200 fold after exposure to IFN-a/b or IL-12. Despite these known innate immune cell functions, accumulating evidence in both mice and humans demonstrates that NK cells are educated and selected during development, possess receptors with antigen specificity, undergo clonal expansion during infection and can generate long-lived memory cells.…”

Section: Conception Of Nk Cellsmentioning

confidence: 99%

NK cell-based immunotherapy for malignant diseases

et al. 2013

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Natural killer (NK) cells play critical roles in host immunity against cancer. In response, cancers develop mechanisms to escape NK cell attack or induce defective NK cells. Current NK cell-based cancer immunotherapy aims to overcome NK cell paralysis using several approaches. One approach uses expanded allogeneic NK cells, which are not inhibited by self histocompatibility antigens like autologous NK cells, for adoptive cellular immunotherapy. Another adoptive transfer approach uses stable allogeneic NK cell lines, which is more practical for quality control and large-scale production. A third approach is genetic modification of fresh NK cells or NK cell lines to highly express cytokines, Fc receptors and/or chimeric tumor-antigen receptors. Therapeutic NK cells can be derived from various sources, including peripheral or cord blood cells, stem cells or even induced pluripotent stem cells (iPSCs), and a variety of stimulators can be used for large-scale production in laboratories or good manufacturing practice (GMP) facilities, including soluble growth factors, immobilized molecules or antibodies, and other cellular activators. A list of NK cell therapies to treat several types of cancer in clinical trials is reviewed here. Several different approaches to NK-based immunotherapy, such as tissue-specific NK cells, killer receptor-oriented NK cells and chemically treated NK cells, are discussed. A few new techniques or strategies to monitor NK cell therapy by non-invasive imaging, predetermine the efficiency of NK cell therapy by in vivo experiments and evaluate NK cell therapy approaches in clinical trials are also introduced.

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“…58,59 NK cell function is determined by the balance of activating-and inhibitory-receptor expression, 60,61 which may be influenced by the liver microenvironment. 62,63 The liver contains a prominent NKG2A 1…”

Section: 22mentioning

confidence: 99%

The liver works as a school to educate regulatory immune cells

Tian

2013

Cell Mol Immunol

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Because of its unique blood supply, the liver maintains a special local immune tolerogenic microenvironment. Moreover, the liver can impart this immune tolerogenic effect on other organs, thus inducing systemic immune tolerance. The network of hepatic regulatory cells is an important mechanism underlying liver tolerance. Many types of liver-resident antigen-presenting cells (APCs) have immune regulatory function, and more importantly, they can also induce the differentiation of circulating immune cells into regulatory cells to further extend systemic tolerance. Thus, the liver can be seen as a type of 'school,' where liver APCs function as 'teachers' and circulating immune cells function as 'students.'

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HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway

Cited by 33 publications

References 32 publications

Memory NK cells: why do they reside in the liver?

Memory NK cells: why do they reside in the liver?

NK cell-based immunotherapy for malignant diseases

The liver works as a school to educate regulatory immune cells

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