Hmox1 Gene Expression in the Liver of Rats With Experimental Tetrachloromethane Hepatitis and Its Change Under the Influence of Hepatoprotectors

Мухаммадиева, Г Ф; Каримов, Д О; Bakirov, A. B.; Кутлина, Т Г; Валова, Я В; Кудояров, Э Р; Хуснутдинова, Н Ю

doi:10.36946/0869-7922-2019-6-45-49

Toksikologičeskij vestnik

2019

DOI: 10.36946/0869-7922-2019-6-45-49

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Hmox1 Gene Expression in the Liver of Rats With Experimental Tetrachloromethane Hepatitis and Its Change Under the Influence of Hepatoprotectors

Г Ф Мухаммадиева¹,

Д О Каримов²,

A. B. Bakirov³

et al.

Abstract: В статье представлено сравнительное влияние гепатопротекторных препаратов (гептрал, мексидол и метилурацил) на экспрессию гена Hmox1 при токсическом поражении печени, индуцированном тетрахлорметаном (CCl 4). Исследования проведены на 70 самцах белых беспородных крыс. Изменения в экспрессии гена Hmox1 имели более выраженный характер через 72 ч после введения CCl 4. Однако под влиянием препаратов изменения кратности экспрессии в наибольшей степени отмечались через 24 ч. Экспрессия гена Hmox1 возрастала в ответ н… Show more

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2023

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Iron metabolism in the cell as a target in the development of potential antimicrobial and antiviral agents

Blagodarov,

Zheltukhina,

Nebolsin

2023

BIOMED KHIM

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The search and creation of innovative antimicrobial drugs, acting against resistant and multiresistant strains of bacteria and fungi, are one of the most important tasks of modern bioorganic chemistry and pharmaceuticals. Since iron is essential for the vital activity of almost all organisms, including mammals and bacteria, the proteins involved in its metabolism can serve as potential targets in the development of new promising antimicrobial agents. Such targets include endogenous mammalian biomolecules, heme oxygenases, siderophores, protein 24p3, as well as bacterial heme oxygenases and siderophores. Other proteins that are responsible for the delivery of iron to cells and its balance between bacteria and the host organism also attract certain particular interest. The review summarizes data on the development of inhibitors and inducers (activators) of heme oxygenases, selective for mammals and bacteria, and considers the characteristic features of their mechanisms of action and structure. Based on the reviewed literature data, it was concluded that the use of hemin, the most powerful hemooxygenase inducer, and its derivatives as potential antimicrobial and antiviral agents, in particular against COVID-19 and other dangerous infections, would be a promising approach. In this case, an important role is attributed to the products of hemin degradation formed by heme oxygenases in vitro and in vivo. Certain attention has been paid to the data on the antimicrobial action of iron-free protoporphyrinates, namely complexes with Co, Ga, Zn, Mn, their advantages and disadvantages compared to hemin. Modification of the well-known antibiotic ceftazidime with a siderophore molecule increased its effectiveness against resistant bacteria.

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Iron metabolism in the cell as a target in the development of potential antimicrobial and antiviral agents

Blagodarov,

Zheltukhina,

Nebolsin

2023

BIOMED KHIM

View full text Add to dashboard Cite

show abstract

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Hmox1 Gene Expression in the Liver of Rats With Experimental Tetrachloromethane Hepatitis and Its Change Under the Influence of Hepatoprotectors

Cited by 1 publication

References 17 publications

Iron metabolism in the cell as a target in the development of potential antimicrobial and antiviral agents

Iron metabolism in the cell as a target in the development of potential antimicrobial and antiviral agents

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