Precision uvbyCaHβ photometry of the metal-deficient, old open cluster, NGC 2506, is presented. The survey covers an area 20 × 20 and extends to V ∼ 18 for b − y and Hβ and to V ∼ 17.0 for c 1 and hk. For V brighter than 16.0, photometric scatter among the indices leads to the recovery of 6 known variables within the cluster core and 5 new variables in the outer 5 of the survey field. Proper motions, radial velocities, and precise multicolor indices are used to isolate a highly probable sample of cluster members from the very rich color-magnitude diagram (CMD). From 257 highly probable members at the cluster turnoff, we derive a reddening estimate of E(b − y) = 0.042 ± 0.001 (E(B − V ) = 0.058 ± 0.001), where the errors refer to the internal standard errors of the mean. [Fe/H] is derived from the A/F dwarf members using both m 1 and hk, leading to [Fe/H]= −0.296 ± 0.011 (sem) and −0.317 ± 0.004 (sem), respectively. The weighted average, heavily dominated by hk, is [Fe/H] = −0.316 ± 0.033. Based upon red giant members, we place an upper limit of ±0.010 on the variation in the reddening across the face of the cluster. We also identify two dozen potential red giant cluster members outside the cluster core. Victoria-Regina isochrones on the Strömgren system produce an excellent match to the cluster for an apparent modulus of (m − M ) = 12.75 ± 0.1 and an age of 1.85 ± 0.05 Gyr.