Hodgkin’s Lymphoma

Tsang, Richard W.; Hodgson, David C.; Crump, Michael

doi:10.1016/j.currproblcancer.2006.04.001

Cited by 13 publications

(6 citation statements)

References 144 publications

(239 reference statements)

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“…Firstly, HD tissues contain variable numbers of reactive lymphocytes and macrophages. These lymphocytes are often of an activated, Th1 phenotype 1,2 . Secondly, these activated lymphocytes could contribute, by means of IL‐2 and IFN‐γ production, to the local activation of macrophages coexpressing TNF‐α, and some matrix metalloproteinases (MMP‐2 and MMP‐9) 12 .…”

Section: Reportmentioning

confidence: 99%

“…Hodgkin's disease (HD) is a neoplasm of Hodgkin–Reed–Sternberg cells, arguably from B‐cell lineage, with variable numbers of reactive or inflammatory lymphocytes, macrophages and other cell populations 1 . These reactive cells are believed to be essential in the pathogenesis of the disease, probably through cytokine secretion 2 .…”

mentioning

confidence: 99%

“…These reactive cells are believed to be essential in the pathogenesis of the disease, probably through cytokine secretion 2 . The main subtypes of HD are nodular lymphocyte predominant HD, classic lymphocyte‐rich HD (CLRHD), nodular sclerosis HD (NSHD), mixed cellularity HD and lymphocyte‐depleted HD 1 …”

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confidence: 99%

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Widespread granuloma annulare and Hodgkin's disease

et al. 2008

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The presence of coexistent disseminated granuloma annulare (GA) and Hodgkin's disease (HD) is rare, with only six reported patients to date. We describe a patient with HD who had limited GA 2 years before the diagnosis of HD; widespread GA appeared after first-line treatment and heralded disease relapse. GA lesions showed hypermetabolic images on positron emission tomography, an interesting finding of unknown significance. We suggest a new pathophysiological mechanism for this association, i.e. that the reactive T-lymphocyte population in HD may contribute to granuloma formation through the secretion of cytokines and the subsequent upregulation of certain metalloproteinases. Diffuse cutaneous GA should raise the possibility of underlying systemic lymphoma or HD.

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Section: Reportmentioning

confidence: 99%

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Widespread granuloma annulare and Hodgkin's disease

et al. 2008

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“…LRCHL is distinguished from NLPHL by the presence of scattered mononuclear cells and Reed–Sternberg cells. The Reed–Sternberg cells have a characteristic CD20−, CD45−, CD79−, CD15+, CD30+ immunophenotype as opposed to the large lymphohistiocytic (L&H) cells that predominate in NLPHL 12,14,15 . The L&H cells found in NLPHL have a delicate, multilobed nucleus resembling a popped popcorn kernel and are CD20+, CD45+, CD79+, CD15−, and C30− 12,14,15 …”

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? Cervical mass in a cat

Steinberg¹,

Keating²

2008

Veterinary Clinical Pathol

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An 8-year-old female spayed domestic shorthair cat was presented for several months of weight loss, decreased appetite, and 2 bilateral, ventral cervical masses. Initial cytologic samples were interpreted as reactive lymphoid hyperplasia. Evaluation of subsequent mass aspirates revealed small numbers of large binucleated and multinucleated cells resembling Reed-Sternberg cells admixed with more numerous small and intermediate-sized lymphocytes. In histopathologic sections, the normal architecture of the lymph node was largely effaced by a slightly heterogeneous mass composed of round cells arranged in densely cellular sheets with a minor population of large (25-microm diameter) mononuclear cells and a few very large (30-40-microm diameter) binucleated or multinucleated cells interpreted as Reed-Sternberg-like cells. Immunohistochemically, the large neoplastic (Reed-Sternberg-like) cells were negative for CD18, CD3, CD20, and CD79a while the background population consisted of about 70% T cells and 30% B cells. This pattern of immunohistochemical staining along with cytologic and histopathologic findings supported a diagnosis of Hodgkin's-like lymphoma, specifically, the lymphocyte-rich subtype. Hodgkin's-like lymphoma has been reported previously in cats and should be suspected when Reed-Sternberg-like cells are observed in cytologic preparations of lymph node aspirates. Histopathology and immunohistochemistry are necessary for a definitive diagnosis.

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“…One feature of many adjuvant cancer treatments is that most patients do not actually benefit from them: the majority would have been cured without adjuvant therapy, or relapse in spite of receiving it. This is the case for adjuvant RT following doxorubicin-based chemotherapy for HL, which reduces the risk of relapse by approximately 7-20% depending on stage, disease bulk, intensity of chemotherapy, and other clinical features [3]. Several recently completed or ongoing clinical trials have been undertaken with the goal of improving the therapeutic ratio of HL treatment by more judiciously selecting patients for RT, and by reducing the radiation dose and volume among patients receiving it.…”

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confidence: 99%