HOGG1 C1245G Gene Polymorphism Associated with Prostate Cancer: A Meta-Analysis

Yang, Chen; Li, Jie; Li, Tianyu; Mo, Zengnan

doi:10.5301/jbm.5000144

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Several meta-analysis studies have made efforts to test the relationship of the hOGG1 rs1052133 polymorphism with PCa risk. Notably, our results are slightly different from those published studies via the improvement of some flaws [ 30 – 32 ]. In 2012, Zhu et al [ 30 ] performed a meta-analysis study, and they found that the rs1052133 polymorphism was related to an elevated risk of PCa in both Whites and Asians.…”

Section: Discussioncontrasting

confidence: 99%

“…However, in the study by Agalliu et al [ 33 ], they focused on the rs3218997 polymorphism and PCa risk, which was incorrectly recruited and synthesized in the study by Zhu et al [ 30 ]. In 2015, Chen et al [ 32 ] performed an updated meta-analysis comprising 11 studies. However, in the pooled analysis, their results failed to show any correlation between the rs1052133 polymorphism and PCa risk.…”

Section: Discussionmentioning

confidence: 99%

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hOGG1 rs1052133 Polymorphism and Prostate Cancer Risk: A Chinese Case-Control Study and Meta-Analysis

Zhang

Hao

et al. 2022

Med Sci Monit

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Background We performed a case-control study and an updated meta-analysis to assess the relationship between the hOGG1 rs1052133 polymorphism and prostate cancer (PCa) risk. Material/Methods We recruited 160 PCa cases and 243 healthy controls. For the meta-analysis, relevant studies were recruited from diverse databases up to April 2022. Genetic risk was evaluated by using an odds ratio (OR) with a corresponding 95% confidence interval (95% CI). The genotypes of this polymorphism were genotyped via the SNaPshot genotyping method. Results In the case-control study, we failed to identify any association between the hOGG1 rs1052133 polymorphism and PCa risk. Negative results were also obtained when stratified analyses were performed based on the patient’s prostatic-specific antigen (PSA) level and Gleason score, as well as tumor, node, and metastasis (TNM) stage. To enlarge the sample size, we performed a restricted updated meta-analysis by recruiting 10 case-control studies (including the current one), and the results suggested that genotypes of rs1052133 polymorphism were significantly associated with an elevated risk of PCa in 2 genetic models – the heterozygote and dominant models. In the stratification analysis by population ethnicity, a significant association of this polymorphism with susceptibility to PCa was found both in the Asian populations and White populations. Conclusions Our case-control and updated meta-analysis study suggest that the hOGG1 rs1052133 polymorphism is a susceptibility factor for PCa, but still needs to be further verified in the Chinese population.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

hOGG1 rs1052133 Polymorphism and Prostate Cancer Risk: A Chinese Case-Control Study and Meta-Analysis

Zhang

Hao

et al. 2022

Med Sci Monit

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“…Further stratified analysis by tumor location indicated a significant association between the hOGG1 rs1052133 and rectal cancer risk [ 1 ]. In term of prostate cancer, significant affects of the hOGG1 rs1052133 were observed in the Asian and Caucasian populations [ 7 ]. In contrast, null association between the hOGG1 rs1052133 and gastric cancer risk was reported in a meta-analysis of 15 studies with 4024 cases and 6022 controls [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility

Zhu

Jia

et al. 2018

EBioMedicine

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Base excision repair (BER) is the main mechanism to repair endogenous DNA lesions caused by reactive oxygen species. BER deficiency is linked with cancer susceptibility and premature aging. Single nucleotide polymorphisms (SNPs) within BER genes have been implicated in various human malignancies. Nevertheless, a comprehensive investigation of their association with Wilms tumor susceptibility is lacking. In this study, 145 cases and 531 sex and age-matched healthy controls were recruited. We systematically genotyped 18 potentially functional SNPs in six core BER pathway genes, using a candidate SNP approach. Logistic regression was employed to evaluate odds ratio (OR) and 95% confidence interval (CI) adjusted for age and gender. Several SNPs showed protective effects against Wilms tumor. Significant associations with Wilms tumor susceptibility were shown for hOGG1 rs1052133 (dominant: adjusted OR = 0.66, 95% CI = 0.45–0.96, P = .030), FEN1 rs174538 (dominant: adjusted OR = 0.66, 95% CI = 0.45–0.95, P = .027; recessive: adjusted OR = 0.54, 95% CI = 0.32–0.93 P = .027), and FEN1 rs4246215 (dominant: adjusted OR = 0.55, 95% CI = 0.38–0.80, P = .002) polymorphisms. Stratified analysis was performed by age, gender, and clinical stage. Moreover, there was evidence of functional implication of these significant SNPs suggested by online expression quantitative trait locus (eQTL) analysis. Our findings indicate that common SNPs in BER genes modify susceptibility to Wilms tumor.

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“…The polymorphism rs1052133 in OGG1 leads to substitution of the amino acid serine for cysteine at codon 326, which shows a decrease in enzyme activity in OGG1-Ser326Cys (13). Moreover, the polymorphism rs1052133 is one of the common SNPs in the OGG1 gene and has been linked to numerous different biological diseases such as breast cancer (14)(15)(16)(17), prostate cancer (18,19), gastric cancer (20), colorectal cancer (21), lung cancer (22) and esophageal cancer (23). Judging by the findings of the previous studies, it is clear that polymorphism rs1052133 has a considerable effect on enzyme activity, which might lead to more oxidative damage (13).…”

Section: Introductionmentioning

confidence: 99%

Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease

Alomair,

Alamri,

Shaik

et al. 2024

Mol Med Rep

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Cardiovascular disease (CVD) is one of the leading causes of mortality worldwide, and multiple single-nucleotide polymorphisms of DNA repair genes have been found to be associated with CVD. The aim of the present study was to assess the effects of the genetic variants of RAD51 recombinase (RAD51) and 8-oxoguanine DNA glycosylase (OGG1) on CVD through genotyping and statistical analysis. Regardless of whether there is a significant association or not, the genotyping data on these two polymorphisms are valuable, because there is limited availability of it in certain populations. A total of 240 blood samples were analyzed and genotyped using TaqMan genotyping; 120 were obtained from cases with a history of CVD, and 120 from cases with no history of CVD. A questionnaire was administered to gather information on age, demographics, sex and clinical features, and confirmation was carried out using medical records. The results of the present study confirmed that the polymorphism rs1052133 in OGG1 had no significant association with CVD. On the other hand, the polymorphism rs1801321 in RAD51 exhibited a significant association with CVD. Collectively, the results of the present study revealed that the polymorphism rs1801321 in RAD51 exhibited a significant association with CVD, however a larger sample size to confirm the present findings, may allow for the early identification of CVD and may aid in the decision-making process concerning treatments for CVD.

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HOGG1 C1245G Gene Polymorphism Associated with Prostate Cancer: A Meta-Analysis

Abstract: In conclusion, we suggest that the hOGG1 C1245G polymorphism might be potentially associated with Pca risk in different ethnicities and countries, especially among Asians. Further studies are needed to confirm these relations.

Cited by 5 publications

References 34 publications

hOGG1 rs1052133 Polymorphism and Prostate Cancer Risk: A Chinese Case-Control Study and Meta-Analysis

hOGG1 rs1052133 Polymorphism and Prostate Cancer Risk: A Chinese Case-Control Study and Meta-Analysis

Base Excision Repair Gene Polymorphisms and Wilms Tumor Susceptibility

Association between polymorphisms of the DNA repair genes RAD51 and OGG1 and risk of cardiovascular disease

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