Hollow fiber-based liquid phase microextraction combined with high-performance liquid chromatography for extraction and determination of some antidepressant drugs in biological fluids

Esrafili, Ali; Yamini, Yadollah; Shariati, Shahab

doi:10.1016/j.aca.2007.10.012

Cited by 151 publications

(77 citation statements)

References 31 publications

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“…In the current method, tizanidine was extracted from plasma using liquid extraction which is extensively for determination of low drug concentrations in biological fluids (Ciccolini et al, 2001;Esrafili et al, 2007;Xiong et al, 2009). Gan et al (2002) developed and validated the estimation of tramadol in human plasma using HPLC followed by liquid-liquid extraction.…”

Section: Resultsmentioning

confidence: 99%

Development and validation of a reverse phase high performance liquid chromatography (HPLC) method for determination of tizanidine in human plasma

Ali¹,

Shoaib²,

Yousuf³

et al. 2014

Afr. J. Pharm. Pharmacol.

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A simple and cost effective high performance liquid chromatography (HPLC) method was developed for determination of tizanidine in human plasma using liquid extraction technique. The assay of tizanidine was performed after extraction of drug from plasma using diethyl ether as extraction solvent. The isocratic elution was performed in Agilent, Zorbax SB-C 18 , 4.6 × 150 mm column maintained at 30°C with mobile phase containing acetonitrile and ammonium acetate in a ratio of 15:85 v/v, respectively. The linear relationship was found within the concentration range of 0.25 to 8 ng/ml, with a flow rate of 1 ml/min and detector wavelength of 230 nm. The evaluated validation parameters were found within the acceptable range. Use of simple HPLC technique with short retention time makes this method a convenient choice for assay of tizanidine in human plasma.

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Section: Resultsmentioning

confidence: 99%

Development and validation of a reverse phase high performance liquid chromatography (HPLC) method for determination of tizanidine in human plasma

Ali¹,

Shoaib²,

Yousuf³

et al. 2014

Afr. J. Pharm. Pharmacol.

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“…39,43 Nesse modo trifásico empregado para fármacos básicos, diversas soluções ácidas vêm sendo utilizadas, como os ácidos clorídrico, acético, fórmico, nítrico, sulfúrico e trifluoracético. 37 Nesses sistemas, os ácidos fortes vêm se destacando, resultando em melhores valores de recuperação quando comparados com soluções aceptoras contendo ácidos fracos.…”

Section: Fase Aceptora No Sistema De Três Fasesunclassified

Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos

Oliveira¹,

Magalhães²,

Santana³

et al. 2008

Quím. Nova

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Ribeirão Preto -SP, BrasilRecebido em 1/12/06; aceito em 30/8/07; publicado na web em 26/2/08 LIQUID-PHASE MICROEXTRACTION (LPME): FUNDAMENTALS AND APPLICATIONS TO THE ANALYSIS OF DRUGS IN BIOLOGICAL SAMPLES. The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solidphase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.Keywords: liquid-phase microextraction; drug analysis; biological samples. INTRODUÇÃOAs técnicas de separação, tais como a cromatografia líquida de alta eficiência (HPLC), a cromatografia gasosa (GC) e a eletroforese capilar (CE), são perfeitamente adequadas para a análise de amostras contendo inúmeros componentes. No entanto, a determinação de analitos presentes em matrizes complexas, tais como plasma, soro, sangue total, homogenatos de tecidos, saliva ou urina, geralmente requer processos prévios de preparação das amostras bem elaborados. 1 Vários motivos justificam estes procedimentos, destacando-se a necessidade de eliminação prévia de parte dos componentes devido à complexidade das matrizes biológicas, a existência de proteínas que podem adsorver nas colunas cromatográficas ou nos capilares, além da necessidade de uma etapa de concentração das substâncias a serem analisadas, geralmente presentes em nível de traços. 1,2 As técnicas mais comumente utilizadas para extração e/ou pré-concentração de compostos presentes em fluidos biológicos são a extração líquido-líquido (LLE) e a extração em fase sólida (SPE). 3 Contudo, as tendências atuais apontam no sentido da utilização de menores quantidades de amostras, até mesmo para análises de traços; obtenção de maior seletividade e especificidade na extração; aumento no potencial para automação ou utilização de métodos "online", reduzindo assim a operação manual; desenvolvimento de métodos menos agressivos ao meio ambiente, com menor desperdí-cio e, o uso de quantidade mínima ou nenhuma de solventes orgâ-nicos. 4,5 Dentro deste contexto, técnicas de microextração que utilizam quantidades mínimas de solventes orgânicos e menos etapas na preparação das amostras vêm sendo desenvolvidas. Entre as principais técnicas de microextração existentes destacam-se a microextração em fase sólida (SPME), a microextração em gota suspensa (SDME) e a extração em membranas ["supported liquid membrane" (SLM), "microporous membrane liquid-liquid extraction" (MMLLE), "liquid-phase mi...

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“…Diffusion of the analytes through the sample matrix increases mass transfer rate to the extraction phase, reduces the time required for reaching extraction equilibrium, and augments the extraction kinetics [50,51]. Diffusion of the analytes can be increased in a number of ways including sonication, heating the sample matrix, and stirring [52,53].…”

Section: Stirring Speedmentioning

confidence: 99%

Fabric Phase Sorptive Extraction Explained

et al. 2017

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Abstract:The theory and working principle of fabric phase sorptive extraction (FPSE) is presented. FPSE innovatively integrates the benefits of sol-gel coating technology and the rich surface chemistry of cellulose/polyester/fiberglass fabrics, resulting in a microextraction device with very high sorbent loading in the form of an ultra-thin coating. This porous sorbent coating and the permeable substrate synergistically facilitate fast extraction equilibrium. The flexibility of the FPSE device allows its direct insertion into original, unmodified samples of different origin. Strong chemical bonding between the sol-gel sorbent and the fabric substrate permits the exposure of FPSE devices to any organic solvent for analyte back-extraction/elution. As a representative sorbent, sol-gel poly(ethylene glycol) coating was generated on cellulose substrates. Five (cm 2 ) segments of these coated fabrics were used as the FPSE devices for sample preparation using direct immersion mode. An important class of environmental pollutants-substituted phenols-was used as model compounds to evaluate the extraction performance of FPSE. The high primary contact surface area (PCSA) of the FPSE device and porous structure of the sol-gel coatings resulted in very high sample capacities and incredible extraction sensitivities in a relatively short period of time. Different extraction parameters were evaluated and optimized. The new extraction devices demonstrated part per trillion level detection limits for substitute phenols, a wide range of detection linearity, and good performance reproducibility.

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Hollow fiber-based liquid phase microextraction combined with high-performance liquid chromatography for extraction and determination of some antidepressant drugs in biological fluids

Cited by 151 publications

References 31 publications

Development and validation of a reverse phase high performance liquid chromatography (HPLC) method for determination of tizanidine in human plasma

Development and validation of a reverse phase high performance liquid chromatography (HPLC) method for determination of tizanidine in human plasma

Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos

Fabric Phase Sorptive Extraction Explained

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