Hollow micro and nanostructures for therapeutic and imaging applications

Yasun, Emir; Gandhi, Sonu; Choudhury, Samraggi; Mohammadinejad, Reza; Benyettou, Farah; Gözübenli, Numan; Arami, Hamed

doi:10.1016/j.jddst.2020.102094

Cited by 35 publications

(20 citation statements)

References 129 publications

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“…For diagnostic purpose, polymeric particles can be incorporated with paramagnetic metals, such as gadolinium (Gd) or manganese (Mn), as contrast agents for imaging. Nanoshells are one of the most efficient candidates to be used in multiple-purpose platforms that enable synergistic multimodal performance [198] . NPs with superparamagnetic iron oxide (SPIO) can be used to detect cancer.…”

Section: Theranostic Applications Of Polymer-based Micro/nanostructuresmentioning

confidence: 99%

Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

Khan

Mir

Qian

et al. 2022

Journal of Advanced Research

111

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Section: Theranostic Applications Of Polymer-based Micro/nanostructuresmentioning

confidence: 99%

Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

Khan

Mir

Qian

et al. 2022

Journal of Advanced Research

111

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“…Together with the functionalized polymeric shell, hollow sphere nanogels can be site specific or stimuli-responsive. Many research groups have used the distinctive properties of a hollow sphere in biomedical applications because the inner void provides a large space for drug encapsulation and the shell thickness is tunable [ 40 ].…”

Section: Core-shell Structure Of Polymeric Nanogelsmentioning

confidence: 99%

Multifunctional Polymeric Nanogels for Biomedical Applications

Kaewruethai

Laomeephol

Pan

et al. 2021

Gels

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Currently, research in nanoparticles as a drug delivery system has broadened to include their use as a delivery system for bioactive substances and a diagnostic or theranostic system. Nanogels, nanoparticles containing a high amount of water, have gained attention due to their advantages of colloidal stability, core-shell structure, and adjustable structural components. These advantages provide the potential to design and fabricate multifunctional nanosystems for various biomedical applications. Modified or functionalized polymers and some metals are components that markedly enhance the features of the nanogels, such as tunable amphiphilicity, biocompatibility, stimuli-responsiveness, or sensing moieties, leading to specificity, stability, and tracking abilities. Here, we review the diverse designs of core-shell structure nanogels along with studies on the fabrication and demonstration of the responsiveness of nanogels to different stimuli, temperature, pH, reductive environment, or radiation. Furthermore, additional biomedical applications are presented to illustrate the versatility of the nanogels.

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“…Several biomolecules such as antibodies, and peptides conjugated with nanoparticles (AuNPs, IONPs, Hollow particles, mesoporus silica) have been labelled using fluorescent dyes for efficient targeting and imaging (15)(16)(17)(18). Peptides have proved to be ideal for targeting due to its low cell toxicity, rapid renal clearance pharmacokinetics, small size, and ease of synthesis or modification, high specificity, accumulation in specific tissues for imageguided diagnosis, and efficient delivery to tumor cells (19).…”

Section: Introductionmentioning

confidence: 99%

Polymeric biocompatible iron oxide nanoparticles labeled with peptides for imaging in ovarian cancer

et al. 2022

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Compared to other nanomaterial, surface-modified iron oxide nanoparticles (IONPs) have gained attraction for cancer therapy applications due to its low toxicity, and long retention time. An innocuous targeting strategy was developed by generation of Fluorescein isothiocyanate (FITC) labeled peptide (Growth factor domain (GFD) and somatomedin B domain (SMB)) functionalized, chitosan coated IONPs (IONPs/C). It can be used to target urokinase plasminogen activator receptor (uPAR), which is a surface biomarker, in ovarian cancer. Binding affinity between uPAR and peptides (GFD and SMB) were revealed by in-silico docking studies. The biophysical characterizations of IONPs, IONPs/C, and IONPs/C /GFD-FITC or SMB-FITC nanoprobes were assessed via Vibrating Sample Magnetometer (VSM), Transmission Electron Microscope (TEM), Dynamic light scattering (DLS), and Fourier Transform Infrared Spectroscopy (FT-IR). Prussian blue staining, fluorescence spectroscopy, and fluorescence imaging were performed to confirm the targeting of nanoprobes with the surface receptor uPAR. The combination of IONPs/C/GFD+SMB showed efficient targeting of uPAR in the tumor microenvironment, and thus can be implemented as a molecular magnetic nanoprobe for cancer cell imaging and targeting.

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Hollow micro and nanostructures for therapeutic and imaging applications

Cited by 35 publications

References 129 publications

Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures

Multifunctional Polymeric Nanogels for Biomedical Applications

Polymeric biocompatible iron oxide nanoparticles labeled with peptides for imaging in ovarian cancer

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