Hollow polymeric (PLGA) nano capsules synthesized using solvent emulsion evaporation method for enhanced drug encapsulation and release efficiency

Raichur, Archana; Nakajima, Yoshio; Nagaoka, Yutaka; Maekawa, Toru; Kumar, D. Sakthi

doi:10.1088/2053-1591/1/4/045407

Cited by 14 publications

(8 citation statements)

References 31 publications

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“…Hollow nanoshells were synthesized as described in our previous paper [29], using simple solvent emulsion evaporation method. Briefly 50 mg of PLGA was dissolved in 1ml of ethyl acetate.…”

Section: Synthesis Of Plga Hollow Nanoparticle Preparation (Plgahnps)mentioning

confidence: 99%

“…To solve this problem we have developed PLGA hollow NPs (PLGAHNPs) that could encapsulate and efficiently release siRNA. In our previous work we showed the potential ability of PLGANPs and PLGAHNPs in drug encapsulation and release efficiency [29].…”

Section: Sirna Duplex Preparationmentioning

confidence: 99%

“…The siRNA release from other NPs was comparatively lower (78% for 105 nm and 0.00015% for 260 ± 0.49 nm). From figure 4C we observed that the NPs of 70 nm showed 94% of siRNA release after 12 h in pH 4.2 and sustained release after 12 h. We performed siRNA release in pH 4.2 to mimic the acidic environment of endosomes in the cells [29,31].…”

Section: Sirna Encapsulation Efficiencymentioning

confidence: 99%

See 2 more Smart Citations

Strategist PLGA Nano-capsules to Deliver siRNA for Inhibition of Carcinoma and Neuroblastoma Cell Lines by Knockdown of MYC Proto-oncogene using CPPs and PNA

Raichur¹,

Nakajima²,

Nagaoka³

et al. 2015

NanoWorld J

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“…Hollow nanoshells were synthesized as described in our previous paper [29], using simple solvent emulsion evaporation method. Briefly 50 mg of PLGA was dissolved in 1ml of ethyl acetate.…”

Section: Synthesis Of Plga Hollow Nanoparticle Preparation (Plgahnps)mentioning

confidence: 99%

Section: Sirna Duplex Preparationmentioning

confidence: 99%

Section: Sirna Encapsulation Efficiencymentioning

confidence: 99%

See 1 more Smart Citation

Strategist PLGA Nano-capsules to Deliver siRNA for Inhibition of Carcinoma and Neuroblastoma Cell Lines by Knockdown of MYC Proto-oncogene using CPPs and PNA

Raichur¹,

Nakajima²,

Nagaoka³

et al. 2015

NanoWorld J

Self Cite

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“…In addition, multiple emulsions composed of an alginic acid solution as inner phase, water, and soybean oil as membrane phase were used as platforms to deliver doxorubicin and temozolomide in drug delivery application. Besides, studies have shown that the effectiveness of cancer chemotherapy treatment efficiency could be increased.…”

Section: Introductionmentioning

confidence: 99%

A novel drug loading and release from a thermoresponsive hydrogel formedin situemulsion polymerization

Zhao

Debeli

Shan

2019

J of Applied Polymer Sci

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A facile thermoresponsive injectable hydrogel is prepared from stearyl methacrylate (SMA) and N-isopropyl acrylamide (NIPAM) copolymers via reversible addition-fragmentation chain-transfer (RAFT) emulsion polymerization method. By regulating the content of the oil phase, emulsions with divergent properties are obtained. The yield stress and the viscosity results of the emulsions increase evidently as the initial content of the oil phase increase from 10 to 40%. The microstructures of 10% oil content sample (SN10) is seen as a dispersed particle whereas 20, 30, and 40% oil content samples (SN20, SN30, and SN40) appear as aggregated particles in a dilute solution that shows the microscopical phase transitions of the emulsions. Increasing the temperature from 15 to 45 C, phase separation takes place, the emulsions contract to squeeze the water. A sharp decrease in particle size is noticed when the temperature increase from 30 to 35 C. In this point, hydrophilic drug procaine is loaded and release experiments are conducted using thermoresponsive injectable hydrogel. The drug loading and release results are evaluated using the Weibull distribution model and the Fick's law of diffusion that precisely works out. A thermoresponsive injectable hydrogel offers an efficient, cost-effective, and scalable approach towards controlled release of drugs.

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“…Poly-D, L-lactide-co-glycolide (PLGA) is one of the most popular biodegradable polymers and has been used extensively for development of nanosystems such as proteins and peptides nanomedicine, nano-vaccines, nanoparticles, as it is metabolised to monomers, lactic acid and glycolic acid in the body with less toxicity. The common methods to prepare PLGA nanoparticles include solvent emulsion-evaporation (Raichur, Nakajima, Nagaoka, Maekawa, & Kumar, 2014), interfacial deposition (Fonseca, Simoes, & Gaspar, 2002) and emulsification-diffusion (Terry, Salaam, Nyairo, Thomas, & Dean, 2014). Gomes et al demonstrated that entrapped eugenol and trans-cinnamaldehyde with PLGA nanoparticles prepared by emulsion evaporation method could inhibit specific pathogens effectively, which can be used in food systems potentially as antimicrobial delivery (Gomes, Moreira, & Castell-Perez, 2011).…”

Section: Nanocarriers For Pulmonary Deliverymentioning

confidence: 99%

Development of Nicotine Loaded Chitosan Nanoparticles for Lung Delivery

Wang¹

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Cigarette smoking has become one of the leading causes of preventable deaths all over the world, causing a serious threat to human wellbeing and a tremendous economic burden to governments. The currently available treatment options for smoking cessation are not efficient. The pulmonary delivery of drugs by methods such as dry powder inhaler (DPI) has been recognized as one of the most efficient routes of drug delivery to the targeted area. The lung delivery of nicotine in this way would be expected to mimic the effects of tobacco smoking and could significantly reduce the negative health effects of smoking that result from nicotine addiction.The aim of this study is to develop nanoparticles with controlled physicochemical properties using biodegradable polymer of chitosan (CS) loaded with nicotine salt for pulmonary delivery as DPI formulations. The outcomes of this project are expected to be a safe and effective CS-based nicotine formulation for pulmonary delivery to treat nicotine dependence. This thesis specially addresses the research questions: (1) how to develop a feasible process to manufacture the nanoparticles suitable for pulmonary drug delivery using biodegradable polymer of CS containing nicotine salt; (2) how to develop an animal model for pulmonary drug delivery from DPI formulation using a nose-only inhalation device.The current therapeutic options for treatment of smoking addiction have been reviewed, and current advancements of technology in pulmonary drug delivery are summarised. Buccal administration of drugs exhibits a low oral bioavailability, and sublingual tablets and chewing gums can be swallowed before being absorbed.Although nasal spray of nicotine is a fast way to deliver nicotine into the bloodstream, Development of Nicotine Loaded Chitosan Nanoparticles for Lung Delivery iii the rate of absorption is still not as rapid as cigarette smoking. Therefore, it is proposed that delivery of nicotine with sustained drug release profile direct into the deep lung is likely to more effectively mimic the rapid effects of cigarette smoking on a physiological level, which could eliminate patient craving and allow the tapering of nicotine level over time to improve patients' compliance.Water in oil (w/o) emulsion crosslinking method has been used to fabricate nicotine hydrogen tartrate (NHT)-loaded CS nanoparticles which separate as solid microaggregates. The physicochemical properties of particles are characterized by a series of techniques. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) shows that the prepared particles are spherical in morphology with rough surface after loading CS particles with NHT. Dynamic Light Scattering (DLS)by Zetasizer determined nanoparticle size ranging from 167.6 nm to 411 nm, while DLS by Mastersizer demonstrated that the microaggregates of these nanoparticles are in the respirable range (<5µm). The surface positive charge as measured by zeta potential tends to decrease with increase of mass ratios of NHT to CS, which is in contr...

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Hollow polymeric (PLGA) nano capsules synthesized using solvent emulsion evaporation method for enhanced drug encapsulation and release efficiency

Cited by 14 publications

References 31 publications

Strategist PLGA Nano-capsules to Deliver siRNA for Inhibition of Carcinoma and Neuroblastoma Cell Lines by Knockdown of MYC Proto-oncogene using CPPs and PNA

Strategist PLGA Nano-capsules to Deliver siRNA for Inhibition of Carcinoma and Neuroblastoma Cell Lines by Knockdown of MYC Proto-oncogene using CPPs and PNA

A novel drug loading and release from a thermoresponsive hydrogel formedin situemulsion polymerization

Development of Nicotine Loaded Chitosan Nanoparticles for Lung Delivery

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