Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

Kleawyothatis, Warannida; Jattujan, Prapaporn; Chumpoochai, Kawita; Chalorak, Pawanrat; Sobhon, Prasert; Meemon, Krai

doi:10.1016/j.jtcme.2022.10.006

Cited by 12 publications

(5 citation statements)

References 54 publications

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“…These worms showed characteristic degenerative features like soluble Aβ oligomers and behavioural deficits, leading to severe paralysis [ 95 ]. Other similar studies confirmed the same observations, and an increased ROS level and decreased lifespan were also noticed [ 96 , 97 ].…”

Section: Alzheimer’s Disease (Ad)supporting

confidence: 81%

“…An RNAi screen in a muscle expression model revealed that the inhibition of mitoferrin-1 diminished mitochondrial ROS levels, resulting in a reduced paralysis rate and prolonged worm lifespan [ 101 ]. Natural products such as Holothuria scabra extracts, Radix Stellariae extracts and D-pintol have been found to reduce Aβ aggregation and decrease ROS levels in Aβ disease models [ 96 , 102 , 103 ].…”

Section: Alzheimer’s Disease (Ad)mentioning

confidence: 99%

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Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans

Wu,

Chen,

et al. 2023

IJMS

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The elevated occurrence of debilitating neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Alzheimer’s disease (AD), Parkinson’s disease (PD) and Machado–Joseph disease (MJD), demands urgent disease-modifying therapeutics. Owing to the evolutionarily conserved molecular signalling pathways with mammalian species and facile genetic manipulation, the nematode Caenorhabditis elegans (C. elegans) emerges as a powerful and manipulative model system for mechanistic insights into neurodegenerative diseases. Herein, we review several representative C. elegans models established for five common neurodegenerative diseases, which closely simulate disease phenotypes specifically in the gain-of-function aspect. We exemplify applications of high-throughput genetic and drug screenings to illustrate the potential of C. elegans to probe novel therapeutic targets. This review highlights the utility of C. elegans as a comprehensive and versatile platform for the dissection of neurodegenerative diseases at the molecular level.

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Section: Alzheimer’s Disease (Ad)supporting

confidence: 81%

Section: Alzheimer’s Disease (Ad)mentioning

confidence: 99%

Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans

Wu,

Chen,

et al. 2023

IJMS

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“…2.1 Caenorhabditis elegans strains, culture, maintenance, and synchronization With its transparent body, short life span, easy culture methods, ease of maintenance, simple neuronal network, conserved neuronal pathways, and robust genetic screens for investigating molecular mechanisms, C. elegans makes an attractive model in various biological disciplines (Kleawyothatis et al, 2023;Yuan et al, 2023). Table 1 lists the C. elegan strains investigated in our study to assess Nicotine's therapeutic potential for PD including N2 (Wild-type nematode), OW13 (pkIs2386, unc-54p::human α-synuclein:: YFP + unc-119(+), BZ555) (egIs1, dat-1p::GFP; green fluorescent protein (GFP)), TJ356 (zls356 [daf-16p::da16a/b::GFP + rol-6(su1006)]), CF1553 ([muIs84 ((pAD76) SOD-3p:: GFP + rol-6)]).…”

Section: Methodsmentioning

confidence: 99%

Nicotine-mediated therapy for Parkinson’s disease in transgenic Caenorhabditis elegans model

Ullah,

Zhao,

Uddin

et al. 2024

Front. Aging Neurosci.

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Parkinson’s disease resultant in the degeneration of Dopaminergic neurons and accumulation of α-synuclein in the substantia nigra pars compacta. The synthetic therapeutics for Parkinson’s disease have moderate symptomatic benefits but cannot prevent or delay disease progression. In this study, nicotine was employed by using transgenic Caenorhabditis elegans Parkinson’s disease models to minimize the Parkinson’s disease symptoms. The results showed that the nicotine at 100, 150, and 200 μM doses reduced degeneration of Dopaminergic neurons caused by 6-hydroxydopamine (14, 33, and 40%), lowered the aggregative toxicity of α-synuclein by 53, 56, and 78%, respectively. The reduction in food-sensing behavioral disabilities of BZ555 was observed to be 18, 49, and 86%, respectively, with nicotine concentrations of 100 μM, 150 μM, and 200 μM. Additionally, nicotine was found to enhance Daf-16 nuclear translocation by 14, 31, and 49%, and dose-dependently increased SOD-3 expression by 10, 19, and 23%. In summary, the nicotine might a promising therapy option for Parkinson’s disease.

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“… Kleawyothatis et al (2022) reported that the whole body (including viscera) and body wall extracts of sea cucumber ( H. scabra ) contain triterpene glycosides or saponins. These extracts have been shown to provide a neuroprotective effect against central nervous system disorders, specifically Alzheimer, in Caenorhabditis elegans models.…”

Section: Future Directionsmentioning

confidence: 99%

Bridging the gap between sustainability and profitability: unveiling the untapped potential of sea cucumber viscera

Muhsin,

Fujaya,

Hidayani

et al. 2023

PeerJ

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Sea cucumbers have high economic value, and in most forms of trade, their body wall is typically the only part that is harvested and sold. The organs of the sea cucumber, collectively known as the viscera, are frequently discarded, contributing to land and water pollution. However, discarded sea cucumber viscera contain various nutrients that can be used in many applications. Therefore, this review highlights the biological and economic aspects of sea cucumbers, followed by a critical discussion of the nutritional value of their internal organs and possible applications, including as functional feed additives in the aquaculture industry, sources of natural testosterone for application in sex reversal and production of monosex population, of neuroprotective agents against central nervous system disorders and of cosmetic ingredients, especially for skin whitening and anti-ageing products. The review further highlights the valorisation potential of viscera to maximize their economic potential, thus providing an enormous prospect for reusing sea cucumber waste, thereby reducing the negative impact of the sea cucumber fishery sector on the environment.

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Holothuria scabra extracts confer neuroprotective effect in C. elegans model of Alzheimer's disease by attenuating amyloid-β aggregation and toxicity

Cited by 12 publications

References 54 publications

Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans

Towards Understanding Neurodegenerative Diseases: Insights from Caenorhabditis elegans

Nicotine-mediated therapy for Parkinson’s disease in transgenic Caenorhabditis elegans model

Bridging the gap between sustainability and profitability: unveiling the untapped potential of sea cucumber viscera

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