Background: One of the highly prevalent and distressing conditions affecting orofacial region is orofacial pain. For proper management and correct diagnosis, clinician needs to have sound knowledge of all painful conditions affecting orofacial region. Our study focuses on myofascial pain-dysfunction syndrome (MPDS). Materials and Methods: A total of 60 patients who reported to the post-graduate Department of Oral Medicine and Radiology were selected randomly after complete clinical and radiographic evaluation into four Groups of 15 patients each. Group A was given conventional treatment including muscle relaxants, analgesics, soft diet, and hot fomentations, Group B transcutaneous electric nerve stimulation therapy (TENS), Group C combined conventional and TENS treatment while Group D as the placebo group. All four groups were analyzed under four parameters of visual analog scale measurement, interincisal mouth opening, muscle tenderness, and clicking. Results: In Group C, a significant improvement was seen in terms of muscle tenderness, pain, and maximum mouth opening (MMO) during different visits. Average values for pain, muscle tenderness, and MMO were significantly better in combined conventional group as compared to conventional, TENS therapy and placebo group. Conclusion: It was concluded at the end of the study that the effective treatment modality in MPDS is combined conventional method as compared to other methods of treatment.