Homeobox Gene Hex Is Essential for Onset of Mouse Embryonic Liver Development and Differentiation of the Monocyte Lineage

Keng, Vincent W.; Yagi, Hideshi; Ikawa, Masahito; Nagano, Takashi; Myint, Zaw; Yamada, Kazuya; Tanaka, Takashi; Sato, Ayuko; Muramatsu, Ikunobu; Okabe, Masaru; Sato, Makoto; Noguchi, T.

doi:10.1006/bbrc.2000.3548

Cited by 172 publications

(135 citation statements)

References 38 publications

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“…mesodermal derivatives, but how these interact with endoderm-autonomous regional cuing needs much more detailed study. There are several notable endodermal region-or organ-specific transcription factors (TFs) that are differentially expressed along the A-P axis, which include Six1 and Six4 (pharyngeal endoderm) (Zou et al, 2006), Sox2 (stomach) (Que et al, 2007), Nkx2.1 (lung) (Minoo et al, 1999), Hhex (liver) (MartinezBarbera et al, 2000;Keng et al, 2000), Pdx1 (pancreas, duodenum, posterior stomach, common bile duct) (Offield et al, 1996), and the caudal homeobox genes Cdx1 and Cdx2 (intestine) (Beck et al, 1995(Beck et al, , 2003.…”

Section: Figmentioning

confidence: 99%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

529

594

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Pancreas oganogenesis comprises a coordinated and highly complex interplay of signaling events and transcriptional networks that guide a step-wise process of organ development from early bud specification all the way to the final mature organ state. Extensive research on pancreas development over the last few years, largely driven by a translational potential for pancreatic diseases (diabetes, pancreatic cancer, and so on), is markedly advancing our knowledge of these processes. It is a tenable goal that we will one day have a clear, complete picture of the transcriptional and signaling codes that control the entire organogenetic process, allowing us to apply this knowledge in a therapeutic context, by generating replacement cells in vitro, or perhaps one day to the whole organ in vivo. This review summarizes findings in the past 5 years that we feel are amongst the most significant in contributing to the deeper understanding of pancreas development. Rather than try to cover all aspects comprehensively, we have chosen to highlight interesting new concepts, and to discuss provocatively some of the more controversial findings or proposals. At the end of the review, we include a perspective section on how the whole pancreas differentiation process might be able to be unwound in a regulated fashion, or redirected, and suggest linkages to the possible reprogramming of other pancreatic cell-types in vivo, and to the optimization of the forward-directed-differentiation of human embryonic stem cells (hESC), or induced pluripotential cells (iPSC), towards mature b-cells. Developmental Dynamics 240:530-565,

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Section: Figmentioning

confidence: 99%

Pancreas organogenesis: From bud to plexus to gland

Pan

Wright

2011

Developmental Dynamics

529

594

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“…Targeted disruption of hhex perturbs growth and differentiation of the mammalian liver primordium (Keng et al, 2000;Martinez Barbera et al, 2000). However, hhex activity is not required for the specification of the prehepatic gut endoderm.…”

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confidence: 99%

“…However, hhex activity is not required for the specification of the prehepatic gut endoderm. The liver diverticulum buds from the gut of hhex mutants, although cells within the diverticulum fail to migrate into the septum transversum (Keng et al, 2000;Martinez Barbera et al, 2000). As a result, the liver remnant in hhex mutants lacks hepatocytes and biliary cells and instead is comprised of hematopoietic precursors that normally reside in the liver, surrounded by the liver capsule (Keng et al, 2000).…”

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confidence: 99%

“…Roles for hhex in embryonic and forebrain patterning (Brickman et al, 2000;Martinez Barbera et al, 2000), and thyroid (Martinez Barbera et al, 2000), and hematopoietic (Keng et al, 2000) development have been described. hhex appears to function as a transcriptional repressor in early development (Brickman et al, 2000;Ho et al, 1999;Tanaka et al, 1999), although recent data suggest it also functions as a transcriptional activator (Denson et al, 2000).…”

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Zebrafish hhex regulates liver development and digestive organ chirality

Wallace

Yusuff

Sonntag

et al. 2001

Genesis

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“…In Hex mutant embryos, Hex is required for definitive endodermal organs (Keng et al, 2000;Martinez Barbera et al, 2000), and for the heart and vascular development (Hallaq et al, 2004), but the formation of endothelial and hematopoietic lineages takes places. During ESC differentiation in vitro, Hex is expressed in the BL-CFCs and acts as a negative regulator of the hemangioblast and its differentiation into definitive hematopoietic and endothelial cells (Nakagawa et al, 2003;Kubo et al, 2005).…”

Section: Molecular Pathways Involved In Hemangioblast Developmentmentioning

confidence: 99%

Molecular and developmental biology of the hemangioblast

Xiong

2008

Developmental Dynamics

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The hemangioblast hypothesis was proposed a century ago. The existence of hemangioblasts is now demonstrated in mouse and human embryonic stem cell (ESC) -derived embryoid bodies (EBs), in the mouse and zebrafish gastrula, and in adults. The hemangioblast is believed to derive from mesodermal cells, and is enriched in the Bry ؉ Flk1 ؉ and Flk1 ؉ Scl ؉ cell populations in EBs and in the posterior primitive streak of the mouse gastrula and in the ventral mesoderm of the zebrafish gastrula. However, recent studies suggest that the hemangioblast does not give rise to all endothelial and hematopoietic lineages in mouse and zebrafish embryos. Although several signaling pathways are known to involve the generation of hemangioblasts, it remains largely unknown how the hemangioblast is formed and what are the master genes controlling hemangioblast development. This review will summarize our current knowledge, challenges, and future directions on molecular and developmental aspects of the hemangioblast.

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Homeobox Gene Hex Is Essential for Onset of Mouse Embryonic Liver Development and Differentiation of the Monocyte Lineage

Cited by 172 publications

References 38 publications

Pancreas organogenesis: From bud to plexus to gland

Pancreas organogenesis: From bud to plexus to gland

Zebrafish hhex regulates liver development and digestive organ chirality

Molecular and developmental biology of the hemangioblast

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